Progress in Lipid Research, Journal Year: 2025, Volume and Issue: 97, P. 101319 - 101319
Published: Jan. 1, 2025
Language: Английский
Gut, Journal Year: 2024, Volume and Issue: 73(10), P. 1749 - 1762
Published: June 8, 2024
Mounting evidence underscores the pivotal role of intestinal barrier and its convoluted network with diet microbiome in pathogenesis inflammatory bowel disease (IBD) colitis-associated colorectal cancer (CRC). Moreover, bidirectional association liver brain, known as gut-brain axis, plays a crucial developing complications, including extraintestinal manifestations IBD CRC metastasis. Consequently, healing represents therapeutic target these inflammatory-dependent disorders, assessment predicting outcomes, response to therapy manifestations.New advanced technologies are revolutionising our understanding paradigm, enabling accurate aiding unravelling complexity axis. Cutting-edge endoscopic imaging techniques, such ultra-high magnification endocytoscopy probe-based confocal laser endomicroscopy, new allowing real-time exploration 'cellular' barrier. Additionally, novel spatial technology platforms, multispectral imaging, upconversion nanoparticles, digital profiling, optical spectroscopy mass cytometry, enable deep comprehensive 'molecular' 'ultrastructural' In this promising landscape, artificial intelligence standardising integrating tools, thereby contributing prediction outcomes.Looking ahead, integrated approach holds promise uncovering targets, breaking ceiling IBD. Novel molecules, dietary interventions modulation strategies aim restore, reinforce, or modulate These advancements have potential for transformative personalised approaches managing
Language: Английский
Citations
19
Annals of Nutrition and Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10
Published: Jan. 23, 2025
Knowledge of the complex interplay between gut microbiota and human health is gradually increasing as it has just recently been a field such great interest. Recent studies have reported that communities microorganisms inhabiting influence immune system through cellular responses shape many physiological pathophysiological aspects body, including muscle bone metabolism (formation resorption). Specifically, affects skeletal homeostasis changes in host metabolism, system, hormone secretion, gut-brain axis. The major role on gut-bone axis due to short-chain fatty acids (SCFAs). They ability regulatory T-cell (Tregs) development activate action Wnt10. SCFA production may be mechanism by which microbial community, serum level insulin-like growth factor 1 (IGF-1), leads regulation homeostasis. A specific SCFA, butyrate, diffuses into marrow where expands Tregs. Tregs induce Wnt ligand Wnt10b CD8+ T cells, leading activation signaling stimulation formation. At hormonal level, effect expressed biphasic serotonin. Some microbiota, spore-forming microbes, regulate serotonin gut, serum, feces. Another group bacterial species (Lactococcus, Mucispirillum, Lactobacillus, Bifidobacterium) can increase peripheral/vascular leptin, turn manages brain
Language: Английский
Citations
2
Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 108825 - 108825
Published: Feb. 1, 2025
Language: Английский
Citations
2
iMeta, Journal Year: 2025, Volume and Issue: 4(1)
Published: Feb. 1, 2025
Abstract Recent advances in understanding the modulatory functions of gut and microbiota on human diseases facilitated our focused attention contribution to pathophysiological alterations many extraintestinal organs, including liver, heart, brain, lungs, kidneys, bone, skin, reproductive, endocrine systems. In this review, we applied “gut–X axis” concept describe linkages between other organs discussed latest findings related axis,” underlying mechanisms potential clinical intervention strategies.
Language: Английский
Citations
2
Cell Metabolism, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Stress and circadian systems are interconnected through the hypothalamic-pituitary-adrenal (HPA) axis to maintain responses external stimuli. Yet, mechanisms of how such signals orchestrated remain unknown. Here, we uncover gut microbiota as a regulator HPA-axis rhythmicity. Microbial depletion disturbs brain transcriptome metabolome in stress-responding pathways hippocampus amygdala across day. This is coupled with dysregulation pacemaker that results perturbed glucocorticoid The resulting hyper-activation HPA at sleep/wake transition drives time-of-day-specific impairments stress response stress-sensitive behaviors. Finally, transplantation confirmed diurnal oscillations microbes underlie altered secretion L. reuteri candidate strain for effects. Our data offer compelling evidence regulates responsiveness manner necessary respond adaptively stressors throughout
Language: Английский
Citations
12
Pharmacological Research, Journal Year: 2024, Volume and Issue: 209, P. 107434 - 107434
Published: Sept. 25, 2024
Mitochondria are crucial organelles that regulate cellular energy metabolism, calcium homeostasis, and oxidative stress responses, playing pivotal roles in brain development neurodegeneration. Concurrently, the gut microbiota has emerged as a key modulator of physiology pathology through microbiota-gut-brain axis. Recent evidence suggests an intricate crosstalk between mitochondrial function, mediated by microbial metabolites can influence activities brain. This review aims to provide comprehensive overview emerging role mitochondria critical mediators axis, shaping health neurological disease pathogenesis. We discuss how such short-chain fatty acids, secondary bile tryptophan metabolites, trimethylamine N-oxide traverse blood-brain barrier modulate processes including production, regulation, mitophagy, neurons glial cells. Additionally, we proposed targeting diet, prebiotics, probiotics, or promising potential therapeutic approach maintain optimizing fitness. Overall, further investigations into its bioenergetics, dynamics, responses will valuable insights axis both states.
Language: Английский
Citations
10
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: May 16, 2024
Importance Research is beginning to elucidate the sophisticated mechanisms underlying microbiota-gut-brain-immune interface, moving from primarily animal models human studies. Findings support dynamic relationships between gut microbiota as an ecosystem (microbiome) within (host) and its intersection with host immune nervous systems. Adding this effects on epigenetic regulation of gene expression further complicates strengthens response. At heart inflammation, which manifests in a variety pathologies including neurodegenerative diseases such Alzheimer’s disease, Parkinson’s Multiple Sclerosis (MS). Observations Generally, research date limited has focused bacteria, likely due simplicity cost-effectiveness 16s rRNA sequencing, despite lower resolution inability determine functional ability/alterations. However, omits all other fungi, viruses, phages, are emerging key members microbiome. Much been done pre-clinical and/or small studies more developed parts world. The observed promising but cannot be considered reliable or generalizable at time. Specifically, causal determined currently. More followed by then little MS. data for MS encouraging this. Conclusions relevance While still nascent, interface may missing link, hampered our progress understanding, let alone preventing, managing, putting into remission diseases. Relationships must first established humans, have shown poorly translate complex physiology environments, especially when investigating microbiome where often overly simplistic. Only can robust conducted humans using mechanistic model
Language: Английский
Citations
9
Current Opinion in Clinical Nutrition & Metabolic Care, Journal Year: 2024, Volume and Issue: 27(3), P. 297 - 303
Published: March 12, 2024
Purpose of review Emerging evidence suggests that the gut microbiota and its metabolites regulate neurodevelopment cognitive functioning via a bi-directional communication system known as microbiota-gut-brain axis (MGBA). Recent findings The MGBA influences brain development function hypothalamic-pituitary axis, vagal nerve, immune signaling, bacterial production neurotransmitters, microbial like short-chain fatty acids, tryptophan derivatives, bile acids. Animal studies show fetal is mediated by maternal activation, diet. Furthermore, manipulation during critical windows development, antibiotic exposure fecal transplantation, can affect behavior in mice. Evidence from human studies, particularly preterm infants, also disrupted colonization may negatively neurodevelopment. Early signatures were linked to favorable adverse neurodevelopmental outcomes. Summary link between evident. Future including experimental larger participant cohort with longitudinal analyses microbes, their metabolites, randomized controlled trials are warranted further elucidate mechanisms MGBA. Identification early, predictive markers could pave way for novel early microbiota-based intervention strategies, such targeted probiotics, vaginal or aimed at improving infant
Language: Английский
Citations
8
Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)
Published: Aug. 25, 2024
The human gastrointestinal tract, boasting the most diverse microbial community, harbors approximately 100 trillion microorganisms comprising viruses, bacteria, fungi, and archaea. profound genetic metabolic capabilities of gut microbiome underlie its involvement in nearly every facet biology, from health maintenance development to aging disease. Recent recognition microbiota – brain axis, referring bidirectional communication network between microbes their host, has led a surge interdisciplinary research. This review begins with an overview current understandings regarding influence on intestinal blood-brain barrier integrity. Subsequently, we discuss mechanisms examining role microbiota-related neural transmission, metabolites, hormones immunity. We propose concept microbiota-mediated multi-barrier modulation potential treatment neurological disorders. Furthermore, lymphatic function is discussed, providing insights into lesser-known conduits ecosystem within brain. In final section, conclude by describing ongoing frontiers understanding axis's impact
Language: Английский
Citations
8
Medicina Clínica, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
1