Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

MedComm, Journal Year: 2024, Volume and Issue: 5(4)

Published: March 15, 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 deaths. Patients with disease (COVID-19) may suffer from diarrhea, sleep disorders, depression, even cognitive impairment, which is associated long COVID during recovery. However, there remains no consensus on effective treatment methods. Studies have found that patients COVID-19 alterations microbiota their metabolites, particularly the gut, be involved regulation of immune responses. Consumption probiotics alleviate discomfort by inflammation oxidative stress. pathophysiological process underlying alleviation COVID-19-related symptoms complications targeting unclear. In current study, we summarize latest research evidence together SARS-CoV-2 vaccine use, focus relationship between use. This work provides probiotic-based interventions improve regulating gut systemic immunity. Probiotics also used as adjuvants to efficacy.

Language: Английский

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Cerebrospinal fluid metabolomics, lipidomics and serine pathway dysfunction in myalgic encephalomyelitis/chronic fatigue syndroome (ME/CFS)

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 3, 2025

We proposed that cerebrospinal fluid would provide objective evidence for disrupted brain metabolism in myalgic encephalomyelitis/chronic fatigue syndroome (ME/CFS). The concept of postexertional malaise (PEM) with disabling symptom exacerbation after limited exertion does not respond to rest is a diagnostic criterion ME/CFS. submaximal exercise provocation cause additional metabolic perturbations. metabolomic and lipidomic constituents from separate nonexercise postexercise cohorts ME/CFS sedentary control subjects were contrasted using targeted mass spectrometry (Biocrates) frequentist multivariate general linear regression analysis diagnosis, exercise, gender, age body index as independent variables. diagnosis was associated elevated serine but reduced 5-methyltetrahydrofolate (5MTHF). One carbon pathways disrupted. Methylation glycine led sarcosine further methylation dimethylglycine choline decreased. Creatine purine intermediates elevated. Transaconitate the tricarboxylic acid cycle along essential aromatic amino acids, lysine, purine, pyrimidine microbiome metabolites. Serine precursor phospholipids sphingomyelins also Exercise consumption lipids controls while metabolites consumed generated controls. findings differ prior hypometabolic plasma. novel generate new hypotheses regarding serine-folate-glycine one serine-phospholipid metabolism, elevation end products catabolic pathways, shifts folate, thiamine other vitamins changes may indicate myelin white matter dysfunction

Language: Английский

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Cerebrospinal Fluid Metabolomics and Proteomics Integration in Neurological Syndromes

Methods in molecular biology, Journal Year: 2025, Volume and Issue: unknown, P. 303 - 321

Published: Jan. 1, 2025

Language: Английский

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Integrating serum pharmacochemistry, network pharmacology and untargeted metabolomics strategies to reveal the material basis and mechanism of action of Feining keli in the treatment of chronic bronchitis

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 335, P. 118643 - 118643

Published: July 31, 2024

Language: Английский

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A Disease Hidden in Plain Sight: Pathways and Mechanisms of Neurological Complications of Post-acute Sequelae of COVID-19 (NC-PASC)

Molecular Neurobiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Language: Английский

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Seeking understanding and action for the neurologic consequences of SARS-CoV-2 infection

Brain Behavior and Immunity, Journal Year: 2023, Volume and Issue: 116, P. 216 - 217

Published: Dec. 7, 2023

Language: Английский

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