A Novel Blood-Based Epigenetic Clock for Intrinsic Capacity Predicts Mortality and is Associated with Clinical, Immunological and Lifestyle Factors DOI Creative Commons
Matías Fuentealba, Laure Rouch, Sophie Guyonnet

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Abstract Age-related decline in intrinsic capacity (IC), defined as the sum of an individual’s physical and mental capacities, is a cornerstone for promoting healthy aging longevity, it emphasizes maximizing function throughout process instead merely treating diseases. However, accurate assessments IC are resource-intensive, molecular cellular basis its poorly understood. Herein, we used INSPIRE-T cohort, consisting 1,014 individuals aged 20 to 102, construct clock, DNA methylation (DNAm)-based predictor trained on clinical evaluation cognition, locomotion, psychological well-being, sensory abilities, vitality. In Framingham Heart Study, age-adjusted DNAm correlates with first- second-generation epigenetic clocks, predicts all-cause mortality, strongly associated changes immune inflammatory biomarkers, functional endpoints, health risk factors, diet.

Language: Английский

Red Blood Cell-Related Phenotype–Genotype Correlations in Chronic and Acute Critical Illnesses (Traumatic Brain Injury Cohort and COVID-19 Cohort) DOI Open Access

Darya A. Kashatnikova,

А. С. Грачева, Ivan V. Redkin

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(3), P. 1239 - 1239

Published: Jan. 31, 2025

Changes in red blood cell (RBC)-related parameters and anemia are common both severe chronic acute diseases. RBC-related phenotypes have a heritable component. However, it is unclear whether the contribution of genetic variability pronounced when hematological affected by physiological stress. In this study, we analyzed phenotype-genotype correlations two exome-sequenced patient cohorts with or at high risk for critical illness: TBI patients admitted rehabilitation COVID-19. analysis exome data, focused on cumulative effects rare high-impact variants (qualifying variants, QVs) specific gene sets, represented Notch signaling pathway genes, based results enrichment anemic three predefined sets interest derived from GO, GWAS, HPO resources. cohorts, was associated QVs GO (TBI: p = 0.0003, OR 2.47 (1.54-4.88); COVID-19: 0.0004, 2.12 (1.39-3.25)) pathway-derived 0.0017, 2.33 (1.35-4.02); 0.0012, =8.00 (1.79-35.74)) sets. multiple linear regression analysis, variables contributed to RBC indices TBI. COVID-19 patients, genes influenced RBC, HGB, HCT levels, whereas other MCHC levels. Thus, exploratory data yielded similar different supporting view that factors may contribute phenotypic performance health conditions.

Language: Английский

Citations

0
Mediterranean vs. Western diet effects on the primate cerebral cortical pre‐synaptic proteome: Relationships with the transcriptome and multi‐system phenotypes DOI Creative Commons
Eloïse Berson, Brett M. Frye, Chandresh R. Gajera

et al.

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(3)

Published: March 1, 2025

Abstract INTRODUCTION Diet quality mediates aging‐related risks of cognitive decline, neurodegeneration, and Alzheimer's disease (AD) through poorly defined mechanisms. METHODS The effects diet on the presynaptic proteome temporal cortex were assessed in 36 female cynomolgus macaques randomized to Mediterranean or Western diets for 31 months. Associations between proteome, determined by synaptometry time‐of‐flight (SynTOF) mass spectrometry, adjacent transcriptome, multi‐system phenotypes using a machine learning approach. RESULTS Six proteins (DAT, Aβ42, calreticulin, LC3B, K48‐Ubiquitin, SLC6A8) elevated consumers ( p < 0.05). Transcriptomic data significantly predicted SynTOF markers. Selected markers correlated with changes white matter volumes, hepatosteatosis, behavioral physiological measures psychosocial stress. DISCUSSION These observations demonstrate that composition drives cortical protein composition, transcriptional profiles strongly predict proteomic profile, closely associated peripheral metabolism, stress responsivity, neuroanatomy, socio‐emotional behavior. Highlights differentially altered which is neurodegeneration decline. Presynaptic transcriptomic cortex, anatomical, physiologic, phenotypes. brain brain‐body interactions are influenced common dietary patterns, suggesting improving may be an effective means maintain health.

Language: Английский

Citations

0
Mediating role of Interleukin-6 in the predictive association of diabetes with Hippocampus atrophy, Amyloid, Tau, and Neurofilament pathology at pre-clinical stages of diabetes-related cognitive impairment DOI Creative Commons

Asma Hallab

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Type-2 diabetes (T 2 DM) has been associated with higher dementia risks, but the mechanisms are still unclear, and there is increasing evidence of role cytokines. Interleukin-6 (IL-6) mediating effect never explored. The study included a subset 1,927 participants from Health Aging Brain Study: Healthy Disparities (HABS-HD) cohort complete data. Cross-sectional longitudinal analyses were performed. Associations studied using multivariable linear, logistic, mediation analysis non-parametric bootstrapping. T DM IL-6 worse executive function, Hippocampus atrophy, lower Aß 42 /Aß 40 ratio, , total Tau, NfL levels. mediated 5% association ([1.5%-10%], p- value<2×10 -16 ), 4% ([0.7%-11%], value=0.014), 8% TMT-B ([0.2%-35%], value=0.046), 11% Tau ([2.5%-40%], value=0.010), ([1.6%-8%], 12% hippocampus atrophy ([3%-49%], value=0.004). results, except TMT-B, replicated in long-lasting on non-previously diagnosed cognitive impairment. captured pre-clinical stage DM-dementia association. novelty that to be further explored accounted for risk stratification preventive measures, particularly ethnic minorities.

Language: Английский

Citations

0
Perspective: Promoting Healthy Aging through Nutrition: A Research Centers Collaborative Network Workshop Report DOI Creative Commons
M. Kyla Shea, Larissa J. Strath, Minjee Kim

et al.

Advances in Nutrition, Journal Year: 2024, Volume and Issue: 15(4), P. 100199 - 100199

Published: March 1, 2024

Within twenty years, the number of adults in United States over age 65 is expected to more than double and 85 triple. The risk for most chronic diseases disabilities increases with age, so this demographic shift carries significant implications individual, health care providers, population health. Strategies that delay or prevent onset age-related are becoming increasingly important. Although considerable progress has been made understanding contribution nutrition healthy aging, it become apparent much remains be learned, especially since aging process highly variable. Most federal programs research studies define all as 'older' do not account physiological metabolic changes occur throughout older adulthood influence nutritional needs. Moreover, adult racially ethnically diverse, cultural preferences other social determinants need considered. Research Centers Collaborative Network (RCCN) sponsored a 1.5-day multi-disciplinary workshop included sessions on Dietary Patterns Health Disease, Timing Targeting Interventions, Disparities Social Context Diet Food Choice. agenda presentations can found at https://www.rccn-aging.org/nutrition-2023-rccn-workshop. Here we summarize workshop's themes discussions highlight gaps if filled will considerably advance our role aging.

Language: Английский

Citations

3
Dietary protein intake interacts with weak handgrip strength and cognitive impairment DOI

Liucheng Zhou,

Cui Zhang

Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: 102(2), P. 359 - 369

Published: Oct. 29, 2024

Handgrip strength correlates with cognitive function, but how gender and dietary protein interact it is unclear.

Language: Английский

Citations

1
Healthy foods, healthy brain? Mediterranean diet is associated with changes in inflammatory pathways affecting brain and behavior in a monkey model DOI

Hanson Kl,

Bauman Md

Brain Behavior and Immunity, Journal Year: 2024, Volume and Issue: 121, P. 119 - 120

Published: July 25, 2024

Language: Английский

Citations

0
A Novel Blood-Based Epigenetic Clock for Intrinsic Capacity Predicts Mortality and is Associated with Clinical, Immunological and Lifestyle Factors DOI Creative Commons
Matías Fuentealba, Laure Rouch, Sophie Guyonnet

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 12, 2024

Abstract Age-related decline in intrinsic capacity (IC), defined as the sum of an individual’s physical and mental capacities, is a cornerstone for promoting healthy aging longevity, it emphasizes maximizing function throughout process instead merely treating diseases. However, accurate assessments IC are resource-intensive, molecular cellular basis its poorly understood. Herein, we used INSPIRE-T cohort, consisting 1,014 individuals aged 20 to 102, construct clock, DNA methylation (DNAm)-based predictor trained on clinical evaluation cognition, locomotion, psychological well-being, sensory abilities, vitality. In Framingham Heart Study, age-adjusted DNAm correlates with first- second-generation epigenetic clocks, predicts all-cause mortality, strongly associated changes immune inflammatory biomarkers, functional endpoints, health risk factors, diet.

Language: Английский

Citations

0