The contribution of age-related changes in the gut-brain axis to neurological disorders

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Jan. 18, 2024

Trillions of microbes live symbiotically in the host, specifically mucosal tissues such as gut. Recent advances metagenomics and metabolomics have revealed that gut microbiota plays a critical role regulation host immunity metabolism, communicating through bidirectional interactions microbiota-gut-brain axis (MGBA). The regulates both systemic contributes to neurodevelopment behaviors host. With aging, composition changes, emerging studies linked these shifts microbial populations age-related neurological diseases (NDs). Preclinical demonstrated microbiota-targeted therapies can improve behavioral outcomes by modulating microbial, metabolomic, immunological profiles. In this review, we discuss pathways brain-to-gut or gut-to-brain signaling summarize metabolites across lifespan disease. We highlight recent investigating 1) changes with aging; 2) how aging maternal microbiome affect offspring health; 3) contribution chronic (e.g., Parkinson's disease, Alzheimer's disease cerebral amyloidosis), acute brain injury, including ischemic stroke traumatic injury.

Language: Английский

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Effects of Traumatic Brain Injury on the Gut Microbiota Composition and Serum Amino Acid Profile in Rats

Cells, Journal Year: 2022, Volume and Issue: 11(9), P. 1409 - 1409

Published: April 21, 2022

Traumatic brain injury (TBI) heavily impacts the body: it damages tissue and peripheral nervous system shifts homeostasis in many types of tissue. An acute compromises “brain–gut-microbiome axis”, a well-balanced network formed by brain, gastrointestinal tract, gut microbiome, which has complex effect: damage to alters composition microbiome; altered microbiome affects TBI severity, neuroplasticity, metabolic pathways through various bacterial metabolites. We modeled rats. Using bioinformatics approach, we sought identify correlations between composition, rate neurological function recovery, blood metabolome. found that caused changes abundance 26 genera. The most dramatic change was observed Agathobacter species. also concentrations several metabolites, specifically citrulline tryptophan. no significant severity pre-existing microbiota or However, discovered some differences two groups subjects showed high low rates respectively. present study highlights role brain–gut-microbiome axis TBI.

Language: Английский

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Physical activity, sedentary behavior and microbiome: A systematic review and meta-analysis

Journal of science and medicine in sport, Journal Year: 2024, Volume and Issue: 27(11), P. 793 - 804

Published: July 9, 2024

The effects of physical activity and sedentary behavior on human health are well known, however, the molecular mechanisms poorly understood. Growing evidence points to as an important modulator composition function microbial communities, while is scarce. We aimed synthesize meta-analyze current about microbiome across different body sites in populations.

Language: Английский

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Concussion and the Autonomic, Immune, and Endocrine Systems: An Introduction to the Field and a Treatment Framework for Persisting Symptoms

Journal of Personalized Medicine, Journal Year: 2025, Volume and Issue: 15(1), P. 33 - 33

Published: Jan. 17, 2025

A significant proportion of patients who sustain a concussion/mild traumatic brain injury endorse persisting, lingering symptoms. The symptoms associated with concussion are nonspecific, and many other medical conditions present similar Medical that overlap symptomatically include anxiety, depression, insomnia, chronic pain, fatigue, fibromyalgia, cervical strain injuries. One the factors may account for these similarities is all disturbances in optimal functioning autonomic nervous system its intricate interactions endocrine immune system—the three primary regulatory systems body. When clinicians working presenting persisting after concussion, evidence-based treatment options drawn from literature limited. We framework assessment following based on available evidence (treatment trials), neuroanatomical principles (research into physiology concussion), clinical judgment. review research supporting premise behavioral interventions designed to stabilize optimize body have potential reduce improve patients. Foundational rehabilitation strategies areas sleep stabilization, fatigue management, physical exercise, nutrition, relaxation protocols, activation outlined along practical implementing intervention modules

Language: Английский

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Study on the toxic-mechanism of triclosan chronic exposure to zebrafish (Danio rerio) based on gut-brain axis

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 844, P. 156936 - 156936

Published: June 27, 2022

Language: Английский

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The altered TBI fecal microbiome is stable and functionally distinct

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: March 13, 2024

Introduction Patients who suffer a traumatic brain injury (TBI) often experience chronic and sometimes debilitating sequelae. Recent reports have illustrated both acute long-term dysbiosis of the gastrointestinal microbiome with significant alterations in composition predicted functional consequences. Methods Working participants from past research, metagenomic stability TBI- associated fecal (FMB) was evaluated by custom qPCR array comparing sample 2015 to one collected 2020. Metatranscriptomics identified differently expressed bacterial genes biochemical pathways TBI FMB. Microbiota that contributed largest RNA amounts set core bacteria most responsible for consequences Results A remarkably stable FMB metagenome similarity (two-tail Spearman nonparametric correlation p < 0.001) observed between 2020 samples subjects TBI. Comparing FMBs healthy controls confirmed extended dysbiotic genera species. Abundance differences average revealed Bacteroides caccae, B . uniformis, Blautia spp., Collinsella Dialister Ordoribacter spp. were significantly different. Functionally, Parabacteroides genus highest percentage sequences control followed as second contributor. In FMB, Corynebacterium Alistipes genus. Pseudomonas distinct top 10 contributing while Ruminococcus unique controls. profiles, had ∼1.5 fold more almost 700 (DEGs) mapped over 100 Bioinformatic analysis DEGs led identifying 311 functions profile 264 By comparison, 30 different abundance ( 0.05, t -test) or detected >80% only cohorts (binary distinction). Discussion Functional included amino acid metabolism, energy carbon source usage, fatty cell wall component production nucleic synthesis processing pathways. Together these data shed light on decades after injury.

Language: Английский

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The role of the microbiota–gut–brain axis in long‐term neurodegenerative processes following traumatic brain injury

European Journal of Neuroscience, Journal Year: 2022, Volume and Issue: 57(2), P. 400 - 418

Published: Dec. 10, 2022

Traumatic brain injury (TBI) can be a devastating and debilitating disease to endure. Due improvements in clinical practice, declining mortality rates have led research into the long-term consequences of TBI. For example, incidence severity TBI been associated with an increased susceptibility developing neurodegenerative disorders, such as Parkinson's or Alzheimer's disease. However, mechanisms linking this alarming association are yet fully understood. Recently, there has groundswell evidence implicating microbiota-gut-brain axis pathogenesis these diseases. Interestingly, survivors often report gastrointestinal complaints animal studies demonstrated dysfunction dysbiosis following injury. Autonomic dysregulation chronic inflammation appear main driver pathologies. Consequently, review will explore potential role development diseases

Language: Английский

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Fecal Microbiota Transplantation Derived from Alzheimer’s Disease Mice Worsens Brain Trauma Outcomes in Wild-Type Controls

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(9), P. 4476 - 4476

Published: April 19, 2022

Traumatic brain injury (TBI) causes neuroinflammation and neurodegeneration, both of which increase the risk accelerate progression Alzheimer's disease (AD). The gut microbiome is an essential modulator immune system, impacting brain. AD has been related with reduced diversity alterations in community composition microbiota. This study aimed to determine whether microbiota from mice exacerbates neurological deficits after TBI control mice. We prepared fecal transplants 18 24 month old 3×Tg-AD (FMT-AD) healthy (FMT-young) FMTs were administered orally young C57BL/6 (wild-type, WT) they underwent controlled cortical impact (CCI) injury, as a model TBI. Then, we characterized samples by full-length 16S rRNA gene sequencing analysis. collected blood, brain, tissues for protein immunohistochemical Our results showed that FMT-AD administration stimulates higher relative abundance genus Muribaculum decrease Lactobacillus johnsonii compared FMT-young WT Furthermore, exhibited larger lesion, increased activated microglia/macrophages, motor recovery one day In summary, observed have detrimental effect aggravate neuroinflammatory response outcomes

Language: Английский

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Gut microbial regulation of innate and adaptive immunity after traumatic brain injury

Neural Regeneration Research, Journal Year: 2023, Volume and Issue: 19(2), P. 272 - 276

Published: July 7, 2023

Acute care management of traumatic brain injury is focused on the prevention and reduction secondary insults such as hypotension, hypoxia, intracranial hypertension, detrimental inflammation. However, imperative to balance multiple clinical concerns simultaneously often results in therapeutic strategies targeted address one concern causing unintended effects other remote organ systems. Recently bidirectional communication between gastrointestinal tract has been shown influence both central nervous system homeostasis health disease. A critical component this axis microorganisms gut known microbiome. Changes microbial populations setting disease, including injury, have reported humans experimental animal models can be further disrupted by off-target patient care. In review article, we will explore important role play regulating brain-resident peripheral immune cell responses after injury. We discuss bacterial metabolites regulation neuroinflammation their potential an avenue for intervention

Language: Английский

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The Use of Biofluid Markers to Evaluate the Consequences of Sport-Related Subconcussive Head Impact Exposure: A Scoping Review

Sports Medicine - Open, Journal Year: 2024, Volume and Issue: 10(1)

Published: Jan. 25, 2024

Amidst growing concern about the safety of sport-related repetitive subconcussive head impacts (RSHI), biofluid markers may provide sensitive, informative, and practical assessment effects RSHI exposure. This scoping review aimed to systematically examine extent, nature, quality available evidence from studies investigating on markers, identify gaps formulate guidelines inform future research. PRISMA extension for Scoping Reviews were adhered to. The protocol was pre-registered through publication. MEDLINE, Scopus, SPORTDiscus, CINAHL, PsycINFO, Cochrane Library, OpenGrey, two clinical trial registries searched (until March 30, 2022) using descriptors impacts, biomarkers, contact sports. Included assessed risk bias quality. Seventy-nine research publications included in review. Forty-nine acute effects, 23 semi-acute 26 long-term most studied sports American football, boxing, soccer, investigated (in descending order): S100 calcium-binding protein beta (S100B), tau, neurofilament light (NfL), glial fibrillary acidic (GFAP), neuron-specific enolase (NSE), brain-derived neurotrophic factor (BDNF), phosphorylated tau (p-tau), ubiquitin C-terminal hydrolase L1 (UCH-L1), hormones. High or moderate found studies, marker-specific conclusions subject heterogeneous limited evidence. Although is weak, some markers-such as NfL-appeared show promise. More markedly, S100B be problematic when evaluating sport. Considering limitations base revealed by this first dedicated marker levels following exposure, field evidently still its infancy. As a result, any recommendation application premature. promise brain health large standardized better-controlled are needed determine markers' utility.

Language: Английский

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