Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 43, P. 100940 - 100940
Published: Dec. 26, 2024
Language: Английский
Nature, Journal Year: 2025, Volume and Issue: 637(8046), P. 536 - 538
Published: Jan. 14, 2025
Language: Английский
Citations
1
Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121368 - 121368
Published: March 1, 2025
Language: Английский
Citations
1
Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 42, P. 100859 - 100859
Published: Sept. 17, 2024
Language: Английский
Citations
4
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 16, 2025
Air pollution is a ubiquitous neurotoxicant associated with alterations in structural connectivity. Good habitual sleep may be an important protective lifestyle factor due to its involvement the brain waste clearance and bidirectional relationship immune function. Wearable multisensory devices provide more objective measures of quantity quality. We investigated whether duration efficiency moderated between prenatal childhood pollutant exposure whole-brain white matter microstructural integrity at ages 10-13 years. used multi-shell diffusion-weighted imaging data collected on 3T MRI scanners Fitbit Charge 2 from 2-year follow-up visit for 2178 subjects Adolescent Brain Cognitive Development Study®. White tracts were identified using probabilistic atlas. Restriction spectrum was performed extract restricted normalized isotropic (RNI) directional (RND) signal fraction parameters all tracts, then averaged calculate global measures. Sleep calculated by summing time spent each stage; dividing bed. Using ensemble-based modeling approach, air concentrations PM 2.5 , NO O 3 assigned child's residential addresses during period (9-month average before birthdate) as well 9- 10 Multi-pollutant linear mixed effects models assessed associations RNI RND sleep-by-pollutant interactions, adjusting appropriate covariates. interacted affect Longer higher context lower compared those similar but shorter efficiency. Low-level poses risk health youth, healthy increase resilience harmful integrity. Future studies should evaluate generalizability these results diverse cohorts utilize longitudinal understand how impact trajectories over time.
Language: Английский
Citations
0
Journal of Child Psychology and Psychiatry, Journal Year: 2025, Volume and Issue: unknown
Published: March 25, 2025
Humans are inevitably exposed to multiple physical and social environmental risk factors, potentially contributing psychiatric problems cognitive deficits; however, the combined effects of prenatal air pollution psychosocial environments on youth remain unclear. This longitudinal study aimed examine how ozone exposure interacts with at 9-10 years affect adolescent limbic system development, cognition, psychotic-like experiences (PLEs) 11-13 years. We analyzed data from 6,778 participants in Adolescent Brain Cognitive Development (ABCD) Study® two time points (baseline: 2-year follow-up). Prenatal was calculated as a 9-month average daily estimates based birth year address. Social factors included school environment neighborhood safety both points. Structural MRI measures bilateral amygdala hippocampus volumes Behavioral consisted cognition PLEs scores Moderation moderated mediation models cluster-robust standard errors were constructed effects, controlling for covariates. Children who prenatally greater had more unfavorable exhibited smaller increase left hippocampal volume, leading poorer PLEs. Moreover, children lived unsafe larger right volume. is first demonstrate pollutant adverse childhood highlighting an important neural mechanism underlying effects.
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 17, 2024
Abstract Background Outdoor air pollution is associated with an increased risk for psychopathology. Although the neural mechanisms remain unclear, pollutants may impact mental health by altering limbic brain regions, such as amygdala. Here, we examine association between ambient exposure and amygdala subregion volumes in 9–10-year-olds. Methods Cross-sectional Adolescent Brain Cognitive Development SM (ABCD) Study ® data from 4,473 participants (55.4% male) were leveraged. Air was estimated each participant’s primary residential address. Using probabilistic CIT168 atlas, quantified total 9 distinct T1- T2-weighted images. First, examined how criteria (i.e., fine particulate matter [PM 2.5 ], nitrogen dioxide, ground-level ozone) 15 PM components related using linear mixed-effect (LME) regression. Next, partial least squares correlation (PLSC) analyses implemented to identify relationships co-exposure well volumes. We also conducted complementary assess apportionment relative volume fractions (RVFs). Results No significant associations detected PLSC, one latent dimension (LD) (52% variance explained) captured a positive calcium several basolateral subregions. LDs identified RVFs (ranging 30% 82% explained), component increases lateral, but decreases medial central, RVFs. Conclusions Fine its are linked differences, potentially playing role adolescent problems. Graphical
Language: Английский
Citations
0
Brain Behavior & Immunity - Health, Journal Year: 2024, Volume and Issue: 43, P. 100940 - 100940
Published: Dec. 26, 2024
Language: Английский
Citations
0