Akkermansia in the gastrointestinal tract as a modifier of human health
Gut Microbes,
Journal Year:
2024,
Volume and Issue:
16(1)
Published: Sept. 21, 2024
are
common
members
of
the
human
gut
microbiota.
Multiple
reports
have
emerged
linking
abundance
Language: Английский
Microbiota–Gut–Brain Axis: Mass-Spectrometry-Based Metabolomics in the Study of Microbiome Mediators—Stress Relationship
Biomolecules,
Journal Year:
2025,
Volume and Issue:
15(2), P. 243 - 243
Published: Feb. 7, 2025
The
microbiota-gut-brain
axis
is
a
complex
bidirectional
communication
system
that
involves
multiple
interactions
between
intestinal
functions
and
the
emotional
cognitive
centers
of
brain.
These
are
mediated
by
molecules
(metabolites)
produced
in
both
areas,
which
considered
mediators.
To
shed
light
on
this
mechanism,
still
largely
unknown,
reliable
characterization
mediators
essential.
Here,
we
review
most
studied
metabolites
axis,
metabolic
pathways
they
involved,
their
functions.
This
focuses
mainly
use
mass
spectrometry
for
determination,
reporting
latest
analytical
methods,
limitations,
future
perspectives.
strategy
qualitative-quantitative
must
be
order
to
elucidate
molecular
mechanisms
underlying
influence
above-mentioned
stress
resilience
or
vulnerability.
Language: Английский
Multi-omics approach identifies gut microbiota variations associated with depression
npj Biofilms and Microbiomes,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: April 28, 2025
The
gut
microbiota
plays
a
potential
role
in
the
pathophysiology
of
depression
through
gut-brain
axis.
This
cross-sectional
study
400
participants
from
PREDIMED-Plus
investigates
interplay
between
and
using
multi-omics
approach.
Depression
was
defined
as
antidepressant
use
or
high
Beck
Inventory-II
scores.
Gut
characterized
by
16S
rRNA
sequencing,
faecal
metabolites
were
analysed
via
liquid
chromatography-tandem
mass
spectrometry.
Participants
with
exhibited
significant
differences
microbial
composition
metabolic
profiles.
Differentially
abundant
taxa
included
Acidaminococcus,
Christensenellaceae
R-7
group,
Megasphaera,
among
others.
Metabolomic
analysis
revealed
15
significantly
altered
metabolites,
primarily
lipids,
organic
acids,
benzenoids,
some
which
correlated
features.
highlights
depression,
paving
way
for
future
research
to
determine
whether
influences
reflects
changes
associated
depression.
Language: Английский
Polysaccharides from fermented garlic attenuate high‐fat diet‐induced obesity in mice through gut microbes
Qi Liu,
No information about this author
Yaqian Li,
No information about this author
Wencan Xu
No information about this author
et al.
Journal of Food Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 10, 2024
Abstract
The
weight
loss
and
lipid‐lowering
effects
of
fermented
garlic
polysaccharides
(BGP)
in
obese
mice
were
analyzed
by
detecting
the
intestinal
flora
short‐chain
fatty
acids.
An
obesity
model
was
established
feeding
a
high‐fat
diet
(HFD)
for
8
weeks.
After
euthanasia,
biochemical
index
testing
hematoxylin
eosin
staining
performed.
Spearman
analysis
used
to
assess
relationship
between
16S
rRNA
sequencing
results
acid
content
mouse
feces.
Compared
with
mice,
BGP
group
had
significantly
reduced
body
serum
triglycerides,
total
cholesterol,
low‐density
lipoprotein
malondialdehyde,
free
acids
serum.
Moreover,
reversed
HFD‐induced
gut
microbiota
dysbiosis,
as
indicated
elevated
populations
Paraclostridium
,
Lachnospiraceae
_UCG_006,
Enterorhabdus
‐NK4A136.
also
increased
contents
acetic,
propionic,
butyric,
valeric
These
indicate
that
may
serve
potential
prebiotic
agent
modulates
particular
bacteria
their
byproducts
play
crucial
role
preventing
diseases
associated
obesity.
Language: Английский