Early Response of CD8+ T Cells in COVID-19 Patients

Journal of Personalized Medicine, Journal Year: 2021, Volume and Issue: 11(12), P. 1291 - 1291

Published: Dec. 3, 2021

Healthy and controlled immune response in COVID-19 is crucial for mild forms of the disease. Although CD8+ T cells play important role this response, there still a lack studies showing gene expression profiles those at beginning disease as potential predictors more severe after first week. We investigated proportion different subpopulations their patterns cytotoxic proteins (perforin-1 (PRF1), granulysin (GNLY), granzyme B (GZMB), A (GZMA), K (GZMK)), cytokine interferon-γ (IFN-γ), apoptotic protein Fas ligand (FASL) from peripheral blood weeks SARS-CoV-2 infection. Sixteen patients nine healthy controls were included. The absolute counts total lymphocytes (p = 0.007), CD3+ 0.05), 0.01) significantly decreased compared to controls. In cell compartment, we observed lower frequency effector memory 1 (EM1) 0.06) 4 (EM4) < 0.001) cells. Higher mRNA PRF1 0.05) FASL fifth day found IFN-γ was downregulated week who progressed moderate week, with symptoms during entire course. GZMK all Our results can lead better understanding inappropriate SARS-CoV2 faster progression

Language: Английский

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CD8+ T-cell immune escape by SARS-CoV-2 variants of concern

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Oct. 27, 2022

Despite the efficacy of antiviral drug repositioning, convalescent plasma (CP), and currently available vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), worldwide disease 2019 (COVID-19) pandemic is still challenging because ongoing emergence certain new SARS-CoV-2 strains known as variants concern (VOCs). Mutations occurring within viral genome, characterized by these emerging VOCs, confer on them ability to efficiently resist escape natural vaccine-induced humoral cellular immune responses. Consequently, VOCs have enhanced infectivity, increasing their stable spread in a given population with an important fatality rate. While process well documented, evasion mechanisms from immunity are not elaborated. In this review, we discussed how adapt inside host cells anti-COVID-19 immunity, focusing effect specific mutations hampering activation CD8 + T-cell immunity.

Language: Английский

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Cellular metabolic basis of altered immunity in the lungs of patients with COVID-19

Medical Microbiology and Immunology, Journal Year: 2022, Volume and Issue: 211(1), P. 49 - 69

Published: Jan. 13, 2022

Language: Английский

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Oral Ad5 Vector‐Based SARS‐CoV‐2 Vaccine Effectively Induces Mucosal and Systemic Immune Responses in BALB/c Mice

Journal of Medical Virology, Journal Year: 2025, Volume and Issue: 97(2)

Published: Feb. 1, 2025

ABSTRACT Mucosal immunity is essential for preventing viral infections through the mucosal route. The emerging SARS‐CoV‐2 variants have posed additional hurdles to efficiency of existing vaccines. rapid development novel vaccines that generate broad and systemic could be most effective strategy address this issue. In study, we developed a recombinant replication‐deficient type‐5 adenoviral vaccine with built‐in double‐strand RNA adjuvant expresses Omicron BA.1 spike (S) antigen (hereinafter referred as “the oral vaccine”). We found two doses in BALB/c mice generated long‐lasting S‐specific immune responses, well neutralizing antibodies SIgA antibodies. addition, compared an mRNA booster, using booster induce both immunity, addressing limitation eliciting immunity. Prospective require further investigation into potential applications, particularly challenge experiments, before clinical trials.

Language: Английский

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Analysis of humoral and cellular responses after vaccination against SARS-CoV-2 in patients with immune-mediated diseases

Diagnostic Microbiology and Infectious Disease, Journal Year: 2025, Volume and Issue: 112(3), P. 116825 - 116825

Published: April 6, 2025

Language: Английский

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