International review of cell and molecular biology, Journal Year: 2024, Volume and Issue: unknown, P. 135 - 197
Published: Sept. 12, 2024
Language: Английский
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(18), P. 14356 - 14356
Published: Sept. 20, 2023
Renal cell carcinoma (RCC) is the most prevalent type of kidney cancer originating from renal tubular epithelial cells, with clear RCC comprising approximately 80% cases. The primary treatment modalities for are surgery and targeted therapy, albeit suboptimal efficacies. Despite progress in research, significant challenges persist, including advanced distant metastasis, delayed diagnosis, drug resistance. Growing evidence suggests that extracellular vesicles (EVs) play a pivotal role multiple aspects RCC, tumorigenesis, immune evasion, response. These membrane-bound released into environment by nearly all types capable transferring various bioactive molecules, RNA, DNA, proteins, lipids, aiding intercellular communication. molecular cargo carried EVs renders them an attractive resource biomarker identification, while their multifarious offers opportunities diagnosis interventions, EV-based therapies. As versatile EVs, exosomes have attracted much attention as nanocarriers biologicals, multi-range signaling effects. growing interest exosomes, there currently no widely accepted consensus on subtypes properties. emerging heterogeneity presents both methodological exciting diagnostic clinical interventions. This article reviews characteristics functions particular reference to recent advances application RCC.
Language: Английский
Citations
44
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 13, 2025
This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple types. As small extracellular vesicles, exosomes exhibit high biocompatibility low immunogenicity, making them ideal vehicles capable of efficiently targeting cells, minimizing off-target damage side effects. aims to explore the potential with a focus on applications chemotherapy, gene immunomodulation. Additionally, challenges related production standardization are analyzed, highlighting importance addressing these issues clinical application. In conclusion, systems offer promising future therapies. Further research should aim enhance efficiency facilitate translation, paving way innovative treatment strategies.
Language: Английский
Citations
25
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5955 - 5955
Published: May 29, 2024
Bladder cancer (BC) is a common genitourinary malignancy that exhibits silent morbidity and high mortality rates because of lack diagnostic markers limited effective treatments. Here, we evaluated the role lncRNA brain cytoplasmic RNA 1 (BCYRN1) in BC. We performed loss-of-function assays to examine effects BCYRN1 downregulation T24 BOY BC cells. found significantly inhibited proliferation, migration, invasion, three-dimensional spheroid formation ability induced apoptosis Additionally, gene set enrichment analysis (GSEA) using sequences from tumor fractions showed decreased expression mRNAs associated with cell cycle. These findings were supported by observations G2/M arrest flow cytometry assays. Finally, examined serum exosomal as biomarker. Clinically, exosomes patients (n = 31) was higher than healthy donors 19; mean difference: 4.1-fold higher, p < 0.01). Moreover, who had undergone complete resection BC, levels 8). Thus, may be promising marker therapeutic target
Language: Английский
Citations
7
Biological Research, Journal Year: 2024, Volume and Issue: 57(1)
Published: Jan. 3, 2024
Abstract Background Tumor-derived small extracellular vesicles (sEVs) can promote tumorigenic and metastatic capacities in less aggressive recipient cells mainly through the biomolecules their cargo. However, despite recent advances, specific molecules orchestrating these changes are not completely defined. Lactadherin is a secreted glycoprotein typically found milk fat globule membrane. Its overexpression has been associated with increased tumorigenesis metastasis breast cancer (BC) other tumors. neither its presence sEVs by BC cells, nor role sEV-mediated intercellular communication have described. The present study focused on of lactadherin-containing from MDA-MB-231 triple-negative (TNBC) (sEV-MDA231) promotion pro-metastatic non-tumorigenic non-metastatic vitro, as well murine model peritoneal carcinomatosis. Results We show that lactadherin it higher sEV-MDA231 compared cell-secreted measured ELISA. Incubation increases migration and, to some extent, tumoroid formation capacity but anchorage-independent growth. Remarkably, blockade results significant decrease those vitro. Similarly, intraperitoneally treatment mice greatly increase malignant ascites tumor micronodules, effects were significantly inhibited when was previously blocked sEV-MDA231. Conclusions As our knowledge, provides first evidence promoter of: (i) ii) nodules. These understanding which be used therapeutic option for malignancies.
Language: Английский
Citations
5
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: Aug. 13, 2024
Urological cancers including those of the prostate, bladder, and kidney, are prevalent often lethal malignancies besides other less common ones like testicular penile cancers. Current treatments have major limitations side effects, recurrence, resistance, high costs, poor quality life. Nanotechnology offers promising solutions through enhanced diagnostic accuracy, targeted drug delivery, controlled release, multimodal imaging. This review reflects clinical challenges nanomedical advances across urological In prostate cancer, nanoparticles improve delineation radiosensitization in radiation therapy, enable fluorescent guidance surgery, enhance chemotherapy penetration metastatic disease. Nanoparticles also overcome bladder permeability barriers to increase residence time intravesical therapy agents. renal nanocarriers potentiate tyrosine kinase inhibitors immunotherapy while gene vectors zinc oxide demonstrate antiproliferative effects. Across modalities, applications nanomedicine include polymeric, liposomal, metal for prodrug photodynamic thermal ablation. Biosafety assessments reveal favorable profiles but translation remains limited, necessitating further trials. conclusion, nanotechnology holds significant potential earlier detection, precise intervention, tailored treatment malignancies, warranting expanded research transform patient outcomes.
Language: Английский
Citations
4
Medical Oncology, Journal Year: 2025, Volume and Issue: 42(3)
Published: Feb. 17, 2025
Abstract Cancer immunotherapy has revolutionized oncology, offering new hope for patients with previously incurable cancers. However, solid tumors remain a significant challenge due to immune evasion, therapeutic resistance, and the immunosuppressive tumor microenvironment. Exosomes, specialized subset of extracellular vesicles, have emerged as promising tools in cancer therapy owing their unique role intercellular communication modulation. These vesicles transport antigens, major histocompatibility complex (MHC) molecules, immune-modulatory cargo, positioning them potential platforms vaccines, drug delivery systems, combinatorial therapies. Advances engineered exosomes improved bioavailability, targeting, stimulation, showcasing personalized medicine. This review highlights multifaceted microenvironment, mechanisms action therapy. Additionally, we discuss emerging strategies overcome clinical technical hurdles, paving way novel effective treatments.
Language: Английский
Citations
0
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: April 16, 2025
The complex etiology and spectrum of kidney diseases necessitate vigilant attention; the focus on early diagnosis intervention in remains a critical issue medical research. Recently, with expanding studies extracellular vesicles, exosomes have garnered increasing interest as promising tool for treatment diseases. Exosomes are nano-sized vesicles that transport diverse array bioactive substances, which can influence various pathological processes associated exhibit detrimental or beneficial effects. Within kidney, derived from glomeruli renal tubules possess ability to enter systemic circulation urine. biomarkers they carry reflect alterations state kidneys, thereby offering novel avenues diagnosis. Furthermore, research confirmed originating multiple cell types therapeutic potential treating disease; notably, those mesenchymal stem cells (MSCs) shown significant efficacy. This comprehensive review summarizes contributions different within kidneys while exploring their physiological roles therein. Additionally, we emphasize recent advancements exosome applications forms over past decades. We not only introduce urinary blood linked found but also explore Finally, discuss existing challenges future directions concerning clinical diagnostic purposes.
Language: Английский
Citations
0
Bioengineering & Translational Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: May 13, 2025
Abstract Microscopic yet powerful, exosomes are leading a revolutionary breakthrough in the field of kidney disease. These membrane‐enclosed vesicles, with diameters ranging from 30 to 150 nm, carry cargo such as proteins, lipids, and nucleic acids, serving bridge information between cells both health disease states. Recently, significant progress has been made understanding critical role deciphering diseases, providing novel perspectives on mechanisms, diagnosis, monitoring, prognosis, treatment. The wide range sources for exosomes, their biocompatibility, remarkable stability, well convenient storage transport capabilities, make them rising star diagnostics. immense diagnostic potential harbored within these tiny structures is rapidly emerging, particularly development liquid biopsy‐based techniques. This article provides comprehensive overview biological functions disease, highlighting primary markers. Furthermore, it explores applications therapeutic delivery, paving way innovative treatment strategies. Finally, we glimpse into future research prospects this field, believing that continuous advancement exosome‐related technologies, diagnostics will become more precise efficient, bringing hope patients. Exosomes propelling new era.
Language: Английский
Citations
0
Cytokine, Journal Year: 2025, Volume and Issue: 192, P. 156961 - 156961
Published: May 17, 2025
Language: Английский
Citations
0
Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12
Published: Dec. 21, 2022
Renal cancer is one of the most extensively studied human tumors today, with clear cell renal carcinoma accounting for approximately 80% all cases. Despite recent advances in research on carcinoma, advanced distant metastasis disease, delay diagnosis, as well drug resistance remain major problems. In years, an important mediator material and information exchange between cells tumor microenvironment, exosomes have attracted widespread attention their role development. It has been reported that tumor-derived may act regulators effect metastasis, formation, providing targets early diagnosis carcinoma. Therefore, extensive study tumour-derived will provide a meaningful reference development diagnostic therapeutic field This article reviews biological progress different aspects premetastatic niche angiogenesis, epithelial-mesenchymal transition during progression addition, also addressed this review. Furthermore, studies found cargoes serum urine, example, series miRNAs, potential to be markers monitoring tumors, which covered article.
Language: Английский
Citations
13