Blood Cells Molecules and Diseases, Journal Year: 2017, Volume and Issue: 70, P. 2 - 12
Published: Aug. 9, 2017
Language: Английский
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Feb. 8, 2025
Diabetic retinopathy (DR), the leading cause of vision loss in elderly individuals, coupled with limited treatment options, has prompted efforts to identify modifiable risk factors associated DR. The purpose this study was explore associations between "weekend warrior" (WW) physical activity (PA) pattern and DR U.S. adults examine how Hb levels mediate relationship. Cross-sectional data were obtained from nationally representative NHANES 2007 2018. PA categorized as inactive, insufficiently active, WW, or regularly active (RA). ultimately included 6145 adults, including 1043 participants 5102 DM but not Multivariate logistic regression modelling indicated that both WW (OR = 0.631, 95% CI 0.487–0.818, P < 0.001) RA 0.738, 0.574–0.959, 0.018) patterns significant protective against compared inactive pattern. Moreover, patterns, did show a association DR, whereas 1.355, 1.054–1.742, factor. Mediation analysis revealed partial mediation effect level on risk, ratio 5.95%. Our are association. In comparison, is most cost effective for prevention.
Language: Английский
Citations
1
Veterinary Research, Journal Year: 2025, Volume and Issue: 56(1)
Published: Feb. 13, 2025
Abstract Pasteurella multocida infects a wide range of animals, causing hemorrhagic septicemia or infectious pneumonia. Iron is an essential nutrient for growth, colonization, and proliferation P. during infection the host, competition iron ions in host critical link pathogenesis this pathogen. In recent years, there has been significant progress study uptake system , including its occurrence regulatory mechanisms. order to provide systematic theoretical basis molecular system, generate new ideas investigation development molecular-targeted drugs subunit vaccines against mechanisms by transferrin receptors, heme siderophores, mechanism expression regulation are all described.
Language: Английский
Citations
1
Toxins, Journal Year: 2019, Volume and Issue: 11(11), P. 660 - 660
Published: Nov. 13, 2019
Vascular diseases are multifactorial, often requiring multiple challenges, or ‘hits’, for their initiation. Intra-vascular hemolysis illustrates well the multiple-hit theory where a first event lyses red blood cells, releasing hemolysis-derived products, in particular cell-free heme which is highly toxic endothelium. Physiologically, derived-products rapidly neutralized by numerous defense systems, including haptoglobin and hemopexin scavenge hemoglobin heme, respectively. Likewise, cellular mechanisms involved, heme-oxygenase 1 upregulation metabolizes heme. However, cases of intra-vascular hemolysis, those systems overwhelmed. Heme exerts effects acting as damage-associated molecular pattern promoting, together with hemoglobin, nitric oxide scavenging ROS production. In addition, it activates complement coagulation systems. Together, these processes lead to endothelial cell injury triggers pro-thrombotic pro-inflammatory phenotypes. Moreover, among glomerular ones display susceptibility explained weaker capacity counteract injury. this review, we illustrate ‘multiple-hit’ through example focus on advance hypotheses explaining observed hemolytic diseases. Finally, describe therapeutic options reducing
Language: Английский
Citations
70
Redox Biology, Journal Year: 2020, Volume and Issue: 37, P. 101687 - 101687
Published: Aug. 14, 2020
Vertebrate hemoglobin (Hb) and myoglobin (Mb) were among the first proteins whose structures sequences determined over 50 years ago. In subsequent pregenomic period, numerous related came to light in plants, invertebrates bacteria, that shared fold, a signature sequence motif characteristic of 3-on-3 α-helical sandwich. Concomitantly, eukaryote bacterial globins with truncated 2-on-2 fold discovered. Genomic information last 20 has dramatically expanded list known globins, demonstrating their existence limited number archaeal genomes, majority genomes an overwhelming genomes. vertebrates, 6 additional globin types identified, namely neuroglobin (Ngb), cytoglobin (Cygb), E (GbE), X (GbX), Y (GbY) androglobin (Adgb). Furthermore, functions beyond familiar oxygen transport storage have been discovered within vertebrate family, including NO metabolism, peroxidase activity, scavenging free radicals, signaling functions. The extension knowledge on suggests original roles must enzymatic, involved defense against toxicity, perhaps also as sensors O2, regulating taxis away or towards high O2 concentrations. this review, we aimed discuss evolution remarkable functional diversity particular focus variety non-canonical expression sites mammalian according impressive variability atypical
Language: Английский
Citations
59
Trends in biotechnology, Journal Year: 2020, Volume and Issue: 39(3), P. 286 - 297
Published: Sept. 7, 2020
Language: Английский
Citations
59
International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(11), P. 6029 - 6029
Published: June 2, 2021
The year 2021 is the 100th anniversary of confirmation neurotransmission phenomenon by Otto Loewi. Over course hundred years, about 100 neurotransmitters belonging to many chemical groups have been discovered. In order celebrate neurotransmitters, we present an overview first two endogenous gaseous transmitters i.e., nitric oxide, and carbon monoxide, which are often termed as gasotransmitters.
Language: Английский
Citations
42
Materials Today Bio, Journal Year: 2023, Volume and Issue: 20, P. 100687 - 100687
Published: June 1, 2023
Chronic wounds have always been considered as "gordian knots" in medicine, which hypoxia plays a key role blocking healing. To address this challenge, although tissue reoxygenation therapy based on hyperbaric oxygen (HBOT) has performed clinically for several years, the bench to bedside still urges evolution of oxygen-loading and -releasing strategies with explicit benefits consistent outcome. The combination various carriers biomaterials gained momentum an emerging therapeutic strategy field, exhibiting considerable application potential. This review gives overview essential relationship between delayed wound Further, detailed characteristics, preparation methods applications oxygen-releasing (ORBMs) will be elaborated, including hemoglobin, perfluorocarbon, peroxide, oxygen-generating microorganisms, those are applied load, release or generate vast relieve hypoxemia bring subsequent cascade effect. pioneering papers regarding ORBMs practice presented trends toward hybrid more precise manipulation summarized.
Language: Английский
Citations
22
Caries Research, Journal Year: 2024, Volume and Issue: 58(2), P. 90 - 107
Published: Jan. 1, 2024
<b><i>Introduction:</i></b> This study investigated the changes in acquired enamel pellicle (AEP) proteome when this integument is formed vivo after treatment with sugarcane-derived cystatin (CaneCPI-5), hemoglobin (HB), and a statherin-derived peptide (StN15), or their combination then exposed to an intrinsic acid challenge. The effectiveness of these treatments preventing erosion was also evaluated. <b><i>Methods:</i></b> Ten volunteers, prophylaxis, 5 crossover phases, rinsed following solutions (10 mL, 1 min): control (deionized water-H<sub>2</sub>O) – group 1, 0.1 mg/mL CaneCPI-5 2, 1.0 HB 3, 1.88 × 10<sup>−5</sup><sc>M</sc> StN15 4, blend 5. Following this, AEP formation occurred (2 h) biopsy µL, 0.01 <sc>m</sc> HCl, pH 2.0, 10 s) conducted on one incisor. analyzed for calcium (Arsenazo method). vestibular surfaces other teeth were treated same acid. Acid-resistant proteins residual collected quantitatively via proteomics. <b><i>Results:</i></b> Compared control, proteins/peptide, mixed isolated, markedly enhanced acid-resistant AEP. Notable increases pyruvate kinase PKM (11-fold, CaneCPI-5), immunoglobulins submaxillary gland androgen-regulated protein 3B (4-fold, StN15), Hb, lysozyme C (2-fold, StN15). Additionally, range not commonly identified but known bind groups tested proteins/peptide either isolation as mixture. mean (SD, m<sc>M</sc>) concentrations released from 3.67 ± 1.48a, 3.11 0.72a, 1.94 0.57b, 2.37 0.90a, 2.38 0.45a 1–5, respectively (RM-ANOVA/Tukey, <i>p</i> < 0.05). <b><i>Conclusions:</i></b> Our findings demonstrate that all treatments, whether using proteins/peptides isolation, However, only showed protecting against erosive demineralization. These results pave way innovative preventive methods erosion, “acquired engineering” techniques.
Language: Английский
Citations
7
Al-mağallaẗ al-ʻirāqiyyaẗ li-l-ʻulūm al-bayṭariyyaẗ/Iraqi journal of veterinary sciences, Journal Year: 2021, Volume and Issue: 35(3), P. 575 - 580
Published: July 1, 2021
Sheep possess desirable characteristics for farmers such as resistance to disease, good acclimation environmental fluctuations, and endurance extreme weather. This may, in part, be due hematology various types of hemoglobin that interact differently external changes; displaying reproductive ability certain conditions. review aims investigate the effect parameters on adaptation performance sheep. Hematological are useful tools detection physiological traits these animals. The reproduction sheep has depended each type breed acclimate different In addition, have also been correlated with adaptability Thus, present provides information association performance, could used vital help determining species or more adapted environments potential.
Language: Английский
Citations
38
Bioresource Technology, Journal Year: 2022, Volume and Issue: 370, P. 128556 - 128556
Published: Dec. 28, 2022
Language: Английский
Citations
27