The Potential of Superoxide Dismutase-Rich Tetraselmis chuii as a Promoter of Cellular Health

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1693 - 1693

Published: Feb. 16, 2025

Tetraselmis chuii (T. chuii) is a green, marine, eukaryotic, microalgae that was authorized in the European Union (EU) as novel food for human consumption 2014, and supplement 2017. This narrative review will provide an overview of preclinical clinical trials assessing efficacy T. chuii-derived ingredient, characterized by high superoxide dismutase (SOD) activity (SOD-rich chuii), to improve various aspects cellular health. Collectively, results from vitro, more importantly vivo research, support SOD-rich potential promoter Principally, ingredient appears function indirect antioxidant boosting intracellular systems. Moreover, it can positively modulate inflammatory status up-regulating anti-inflammatory down-regulating pro-inflammatory cytokines factors. In addition, promote health though protecting DNA damage, immune function, strengthening cell structure integrity, modulating signaling pathways. There also some evidence suggest may mitochondrial through up-regulation genes linked biogenesis ATP synthesis. From conducted date, transcriptional activation nuclear factor erythroid 2-related 2 (NRF2) sirtuin 1 (SIRT1) appear be important mediating effects on These exciting preliminary observations represent natural blue with enhance

Language: Английский

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Ficus pumila fruit polysaccharide alleviates OVA-induced allergic asthma mice through the MAPK/NF-κB signaling pathway

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 105827 - 105827

Published: Jan. 1, 2025

Language: Английский

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C-reactive protein-induced injury in Mycoplasma pneumoniae -infected lung epithelial cells is mediated by the P38 MAPK/mitochondrial apoptosis pathway

Microbiology Spectrum, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Patients with Mycoplasma pneumoniae (MP) infections have markedly higher C-reactive protein (CRP). We investigated how CRP contributes to lung epithelial cell death following MP infection. levels were assessed in children diagnosed pneumonia (MPP) and A549 cells infected MP. genetically modified overexpress CRP. Effects on viability, apoptosis, reactive oxygen species (ROS) mitochondrial membrane potential (ΔΨm) evaluated. The expression of proteins implicated the p38 MAPK/mitochondrial apoptotic pathway was analyzed. protective effects MAPK inhibitor SB203580 protector cyclosporin A (CsA) assessed. elevated both MPP patients MP-infected compared controls. Increased apoptosis reduced viability observed cells. overexpression led upregulation pathway, increased cytoplasmic Cyt C, decreased Tom 20 ΔΨm, ROS. Pretreatment or posttreatment CsA damage enhanced survival. during infection promote by activating pathway. Targeting this could offer therapeutic reduce patients.IMPORTANCEThis study provides critical information understanding pathophysiological mechanisms for concerning mediating injury. This outlines significant increase shows its direct involvement through By explaining possibility targeting connected signaling devise interventions amelioration is brought light. implications such data are not merely added knowledge disease pathobiology but also it brings new promise novel intervention strategies result improved clinical outcomes. elucidation specific molecular targets inside heralds a area regarding direction future research application humanity general broader relevance impact respiratory diseases.

Language: Английский

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CBX2 as a therapeutic target in colorectal cancer: insights into the altered chromatin accessibility via RUNX1-CBX2-MAP4K1 axis

Oncogene, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Language: Английский

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Pre-clinical evidence for mitochondria as a therapeutic target for luteolin: a mechanistic view

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111492 - 111492

Published: March 1, 2025

Language: Английский

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The involvement of PI3K–Akt signaling in the clinical and pathologic findings of iMCD-TAFRO and NOS subtypes.

Modern Pathology, Journal Year: 2025, Volume and Issue: unknown, P. 100782 - 100782

Published: April 1, 2025

Idiopathic multicentric Castleman disease is a rare lymphoproliferative disorder that clinically classified into idiopathic plasmacytic lymphadenopathy (IPL); thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO); not otherwise specified (NOS). Although each subtype shows varying degrees of hypervascularity, no statistical data on the degree vascularization have been reported. Additionally, mechanisms underlying in clinical are poorly understood. Here, we aimed to clarify these by evaluating histopathological characteristics across 37 patients performing whole-transcriptome analysis focusing angiogenesis-related gene expression. Histologically, TAFRO NOS exhibited significantly higher than IPL (IPL vs TAFRO: p < 0.001, NOS: = 0.002). In addition, germinal centers (GCs) were more atrophic IPL. NOS, "whirlpool vessels" GCs seen most cases (TAFRO: 9/9, 100%, 6/8, 75%), but 0.007). Likewise, immunostaining for Ets-related revealed levels endothelial cells (p 0.014), associated with number interfollicular areas compared (TAFRO IPL: Gene expression PI3K-Akt signaling pathway was enriched (TAFRO/NOS) groups. This pathway, which may be activated vascular growth factor A some integrins, known affect angiogenesis increasing permeability, explain manifestations anasarca and/or fluid retention TAFRO/NOS. These results suggest plays an important role pathogenesis

Language: Английский

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Boosting Cellular Longevity Through Intracellular ATP Modulation

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Aging results from the gradual accumulation of molecular damage as a result cellular processes and is characterized by impaired functions, most notably an age-related decline in ATP production. However, causal relationship between homeostasis aging has not been established. In this study, we employed nucleotide transporter eukaryotic intracellular parasite to directly alter levels budding yeast cells exchange it with extracellular milieu. We found that depletion significantly shortens lifespan, whereas supplementation medium fully restores it. Analysis gene expression showed inhibition catabolic suggesting increased suppresses glucose metabolism. Our also leads lifespan extension. Overall, our study revealed direct impact on regulation lifespan. This work offers new insights into bioenergetic control positions energy metabolism promising target for longevity interventions.

Language: Английский

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Attenuation of PM2.5-Induced Lung Injury by 4-Phenylbutyric Acid: Maintenance of [Ca2+]i Stability between Endoplasmic Reticulum and Mitochondria

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1135 - 1135

Published: Sept. 8, 2024

Fine particulate matter (PM2.5) is a significant cause of respiratory diseases and associated cellular damage. The mechanisms behind this damage have not been fully explained. This study investigated two types (inflammation pyroptosis) induced by PM2.5, focusing on their relationship with organelles (the endoplasmic reticulum mitochondria). Animal models demonstrated that PM2.5 induces excessive stress (ER stress), which lung in rats. was confirmed pretreatment an ER inhibitor (4-Phenylbutyric acid, 4-PBA). We found that, vitro, the intracellular Ca2+ ([Ca2+]i) dysregulation rat alveolar macrophages stress. Changes mitochondria-associated membranes (MAMs) result abnormal mitochondrial function. further massive expression NLRP3 GSDMD-N, detrimental to cell survival. In conclusion, our findings provide valuable insights into between [Ca2+]i dysregulation, damage, inflammation pyroptosis under PM2.5-induced conditions. Their interactions ultimately impact health.

Language: Английский

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Fluorine-18-Labeled Positron Emission Tomography Probe Targeting Activated p38α: Design, Synthesis, and In Vivo Evaluation in Rodents

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 600 - 600

Published: April 20, 2025

Background/Objectives: The kinase p38α, a member of the mitogen-activated protein (MAPK) family, is activated by external stimuli and plays crucial role in inflammation, tumor growth, metabolic disorders. In particular, p38α involved thermogenesis metabolism glucose brown adipose tissue (BAT), it contributes to suppression obesity diabetes. noninvasive imaging could help elucidate diverse pathological processes, including inflammatory conditions. This study aimed develop evaluate novel fluorine-18-labeled positron emission tomography (PET) probe for vivo. Methods: We designed 6-(4-[18F]fluoro-2-fluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one ([18F]R1487) replacing fluorine atom R1487, which highly selective inhibitor, with 18F. A tributylstannyl precursor was reacted [18F]KF presence copper catalyst synthesize [18F]R1487. Biodistribution studies PET/computed (CT) were performed on normal mice vivo potential Results: [18F]R1487 obtained decay-corrected radiochemical conversion 30.6 ± 5.6% yield 6.9 3.6% purity >99% after reversed-phase high-performance liquid chromatography purification. biodistribution demonstrated high rapid radioactivity accumulation BAT (16.3 2.7 %ID/g at 5 min post-injection), consistently BAT-to-blood ratio (>5 over 2 h post-injection). PET/CT successfully visualized contrast. Conclusions: These results suggest that promising PET vivo, has applications pathophysiological conditions such as cancer,

Language: Английский

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The Journey of p38 MAP Kinase Inhibitors: From Bench to Bedside in Treating Inflammatory Diseases

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 280, P. 116950 - 116950

Published: Oct. 11, 2024

Language: Английский

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