International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2520 - 2520
Published: March 11, 2025
Melatonin,
a
natural
hormone
with
antioxidant,
anti-inflammatory,
and
regenerative
properties,
has
gained
increasing
attention
in
tissue
engineering
for
its
ability
to
enhance
the
therapeutic
potential
of
biopolymeric
scaffolds.
These
scaffolds,
designed
mimic
extracellular
matrix,
provide
structural
support
bioactive
environment
regeneration.
By
integrating
melatonin,
researchers
aim
create
multifunctional
scaffolds
that
promote
cell
proliferation,
modulate
inflammatory
responses,
improve
wound
healing
outcomes.
Challenges
utilizing
melatonin
include
maintaining
stability
under
light,
heat,
oxygen
exposure,
optimizing
release
profile
sustained
effects.
Innovative
fabrication
methods,
such
as
electrospinning,
3D
printing,
lyophilization,
have
enabled
precise
control
over
scaffold
architecture
delivery.
techniques
ensure
enhanced
interactions
target
tissues
tailored
regeneration
processes.
Combining
growth
factors,
cytokines,
antimicrobial
agents
offers
applications,
from
chronic
management
bone
nerve
Continued
research
this
field
promises
transformative
solutions
medicine,
expanding
clinical
applicability
melatonin-enriched
This
review
highlights
current
progress,
challenges,
opportunities
associated
harnessing
melatonin’s
within
frameworks.
Coatings,
Journal Year:
2024,
Volume and Issue:
14(3), P. 253 - 253
Published: Feb. 20, 2024
As
a
biomedical
material,
porous
titanium
alloy
has
gained
widespread
recognition
and
application
within
the
field
of
orthopedics.
Its
remarkable
biocompatibility,
bioactivity,
mechanical
properties
establish
it
as
promising
material
for
facilitating
bone
regeneration.
A
well-designed
structure
can
lower
material’s
modulus
while
retaining
ample
strength,
rendering
more
akin
to
natural
tissue.
The
progression
additive
manufacturing
(AM)
technology
significantly
propelled
advancement
implants,
simplifying
production
such
structures.
AM
allows
customization
implants
with
various
shapes
sizes
tailored
individual
patients.
Additionally,
enables
design
microscopic-scale
structures
closely
mimic
bone,
thus
opening
up
avenues
development
that
better
stimulate
This
article
reviews
research
progress
on
structural
preparation
methods
analyzes
parameters
affect
performance
implant,
discusses
medical
alloys.
By
comparing
effects
different
porosity,
pore
shape,
size
implant
performance,
was
concluded
diameters
in
range
500~800
μm
porosity
70%–90%
have
bone-regeneration
effects.
At
same
time,
when
is
diamond,
rhombohedral,
or
cube
structure,
effects,
providing
reference
clinical
implants.
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials,
Journal Year:
2024,
Volume and Issue:
151, P. 106391 - 106391
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Nov. 12, 2024
Scaffold
porosity
is
a
critical
factor
in
replicating
the
complex
vivo
microenvironment,
directly
influencing
cellular
interactions,
migration,
nutrient
transfer,
vascularization,
and
formation
of
functional
tissues.
For
optimal
tissue
formation,
scaffold
design
must
account
for
various
parameters,
including
material
composition,
morphology,
mechanical
properties,
compatibility.
This
review
highlights
importance
interconnected
pore
size,
emphasizing
their
impact
on
behavior
across
several
engineering
domains,
such
as
skin,
bone,
cardiovascular,
lung
Specific
size
ranges
enhance
functionality
different
tissues:
small
pores
(∼1–2
µm)
aid
epidermal
cell
attachment
skin
regeneration,
moderate
(∼2–12
support
dermal
larger
(∼40–100
facilitate
vascular
structures.
bone
engineering,
multi-layered
scaffolds
with
smaller
(50–100
foster
attachment,
while
(200–400
diffusion
angiogenesis.
Cardiovascular
tissues
benefit
from
sizes
(∼25–60
to
balance
integration
diffusion.
By
addressing
challenges
optimizing
distributions,
this
provides
insights
into
innovations,
ultimately
advancing
regeneration
strategies.
Ceramics International,
Journal Year:
2023,
Volume and Issue:
49(11), P. 19355 - 19363
Published: March 10, 2023
As
the
main
means
of
treating
bone
defects,
grafts
are
in
high
demand.
Recently,
development
suitable
graft
replacement
materials
has
received
significant
research
attention
because
drawbacks
autologous
and
allogeneic
grafts.
The
applications
ceramic
materials,
such
as
calcium
phosphate,
sulfate,
hydroxyapatite,
limited
by
various
factors.
Calcium
silicate,a
new
material,
exhibits
biocompatibility
osteoinductivity.
This
paper
summarizes
methods
for
synthesizing
silicate
compares
their
advantages
disadvantages
detail.
mechanical
antimicrobial
properties
can
be
improved
to
fulfil
biological
requirements
adding
B2O3,
SiO2,
Ag,
Zn,
Ti,
chitosan.
Recent
progress
ceramics
preliminary
clinical
well
3D
printing
is
also
reviewed,
which
provide
impetus
application
ceramics.
Finally,
article
suggests
future
directions
silicate-based
offer
prospects
repair
materials.
