Ceramics International, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 1, 2024
Language: Английский
Biomimetics, Journal Year: 2024, Volume and Issue: 9(7), P. 409 - 409
Published: July 5, 2024
The aim of this study is to provide an overview the current state-of-the-art in fabrication bioceramic scaffolds for bone tissue engineering, with emphasis on use three-dimensional (3D) technologies coupled generative design principles. field modern medicine has witnessed remarkable advancements and continuous innovation recent decades, driven by a relentless desire improve patient outcomes quality life. Central progress which holds immense promise regenerative applications. Scaffolds are integral engineering serve as 3D frameworks that support cell attachment, proliferation, differentiation. A wide array materials been explored scaffolds, including bioceramics (i.e., hydroxyapatite, beta-tricalcium phosphate, bioglasses) bioceramic–polymer composites, each offering unique properties functionalities tailored specific Several methods, such thermal-induced phase separation, electrospinning, freeze-drying, gas foaming, particle leaching/solvent casting, fused deposition modeling, printing, stereolithography selective laser sintering, will be introduced thoroughly analyzed discussed from point view their characteristics, have proven invaluable obtaining scaffolds. Moreover, highlighting important role scaffold optimization, review seeks pave way development innovative strategies personalized solutions address significant gaps literature, mainly related complex defects engineering.
Language: Английский
Citations
13
Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e36258 - e36258
Published: Aug. 1, 2024
Natural bone tissue has the certain function of self-regeneration and repair, but it is difficult to repair large damage. Recently, although autologous grafting "gold standard" for improving high cost, few donor sources. Besides, allogeneic causes greater immune reactions, which hardly meet clinical needs. The engineering (BTE) been developed promote repair. Gelatin, due its biocompatibility, receives a great deal attention in BTE research field. However, disadvantages natural gelatin are poor mechanical properties single structural property. With development BTE, often used combination with range natural, synthetic polymers, inorganic materials achieve synergistic effects complex physiological process review delves into fundamental structure unique gelatin, as well excellent necessary scaffold materials. Then this explores application modified three-dimensional (3D) scaffolds various structures including 3D fiber scaffolds, hydrogels, nanoparticles. In addition, focuses on efficacy composite consisting or polymeric materials, bioactive ceramics metallic/non-metallic defects. these gelatin-based provides new ideas design good biosafety.
Language: Английский
Citations
13
Materials Science and Engineering R Reports, Journal Year: 2024, Volume and Issue: 159, P. 100801 - 100801
Published: May 3, 2024
Language: Английский
Citations
12
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(2), P. 2791 - 2813
Published: Jan. 6, 2025
Transplantation of bone implants is currently recognized as one the most effective means treating defects. Biobased and biodegradable polyester composites combine good mechanical degradable properties polyester, thereby providing an alternative for implant materials. Bone tissue engineering (BTE) accelerates defect repair by simulating microenvironment. Composite scaffolds support formation further accelerate process repair. The introduction 3D printing technology enables preparation to be more precise, reproducible, flexible, which a very promising development. This review presents physical BTE summarizes strategies adopted domestic international scholars improve based on biobased polyester/ceramic in recent years. In addition, future development prospects field challenges expanding production clinical applications are presented.
Language: Английский
Citations
1
The International Journal of Lower Extremity Wounds, Journal Year: 2024, Volume and Issue: unknown
Published: April 15, 2024
Nanohydrogel wound healing refers to the use of nanotechnology-based hydrogel materials promote wounds. Hydrogel dressings are made up a three-dimensional network hydrophilic polymers that can absorb and retain large amounts water or other fluids. Nanohydrogels take this concept further by incorporating nanoscale particles structures into matrix. These nanoparticles be various materials, such as silver, zinc oxide, derived from natural substances like chitosan. The inclusion provide additional properties benefits dressings. designed release bioactive substances, growth factors drugs, in controlled manner. This allows for targeted delivery therapeutics site, promoting reducing inflammation. Nanoparticles reinforce structure hydrogels, improving their mechanical strength stability. often incorporate antimicrobial nanoparticles, silver oxide. have shown effective activity against wide range bacteria, fungi, pathogens. By them dressings, nanohydrogels help prevent reduce risk infection encapsulate factors, peptides, sustained therapeutic agents promotes facilitating cell proliferation, inflammation, supporting tissue regeneration. unique nanohydrogels, including ability maintain moist environment deliver agents, accelerate process. creating an optimal repair, faster more efficient
Language: Английский
Citations
7
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2024, Volume and Issue: 157, P. 106661 - 106661
Published: July 14, 2024
Language: Английский
Citations
7
Biomedical Materials, Journal Year: 2025, Volume and Issue: 20(2), P. 025017 - 025017
Published: Jan. 22, 2025
Calcium phosphate-based bioscaffolds are used for bone tissue regeneration because of their physical and chemical resemblance to human bone. Calcium, phosphate, sodium, potassium, magnesium, silicon important components The successful biomimicking characteristics involves incorporating all the elements into scaffold material. In this work, Mg-Whitlockite (WH) Silicate (CS) were selected as matrix reinforcement respectively, desirable elemental composition regenerative properties. magnesium in WH increases mineralization bone, ions CS support vascularization. Mg-WH was synthesized using wet method, powder characterization tests performed. Response surface methodology (RSM) is design experiments with a combination material compositions, infill ratios (IFs), sintering temperatures (STs). WH/CS bioceramic composite 3D printed three different compositions: 100/0, 75/25, 50/50 wt%, IFs 50%, 75%, 100%. mechanical study samples conducted result optimized RSM. ANOVA (Analysis Variance) establish relationship between input parameters responses. IF ST 1150 °C, which bring out best possible characteristics. RSM response density 2.27 g cm-3, porosity 36.74%, wettability 45.79%, shrinkage 25.13%, compressive strength 12 MPa, modulus 208.49 MPa 92% desirability. biological studies prepared parameters. confirmed capabilities scaffolds applications.
Language: Английский
Citations
0
Advances in experimental medicine and biology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Proceedings of the Institution of Mechanical Engineers Part H Journal of Engineering in Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: March 22, 2025
Additive manufacturing (AM) is revolutionizing healthcare by enabling the creation of customized 3D printed (3DP) medical equipment, implants, orthoses, prosthetics, drugs, and organs. With availability different types materials suitable for 3DP applications, this technology allows precise fabrication patient-oriented dental orthopedic devices, significantly improving fit functionality. Additionally, such as Oral Dispersible Formulations (ODFs) polypills, are surpassing traditional “one pill fits all” concept, offering more tailored medication solutions. This innovation also supports development personalized medications bioprinted tissues, opening way advancements in regenerative therapies. 3D-bioprinted organs addressing growing demand organ transplants. In surgical planning, 3D-printed anatomical models provide students professionals with hands-on practice, which crucial skill understanding complex anatomies. Surgeons can practice refine techniques before actual procedures, enhancing precision outcomes during real operations. paper focus on highlighting progression motivations behind cross-disciplinary applications AM within sector providing drug delivery systems diagnostic tools treatment refinement. designed a broad audience, including researchers, who interested exploring implications transformative technology.
Language: Английский
Citations
0
Ceramics International, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0