The ‘Oma’s of the Gammas—Cancerogenesis by γ-Herpesviruses DOI Creative Commons
A K Banerjee, Debashree Dass,

Soumik Mukherjee

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(12), P. 1928 - 1928

Published: Dec. 17, 2024

Epstein–Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV), which are the only members of gamma(γ) herpesviruses, oncogenic viruses that significantly contribute to development various human cancers, such as Burkitt’s lymphoma, nasopharyngeal carcinoma, Hodgkin’s sarcoma, primary effusion lymphoma. Oncogenesis triggered by γ-herpesviruses involves complex interactions between viral genetics, host cellular mechanisms, immune evasion strategies. At genetic level, crucial oncogenes participate in disruption cell signaling, leading uncontrolled proliferation inhibition apoptosis. These proteins can modulate several pathways, including NF-κB JAK/STAT play essential roles survival inflammation. Epigenetic modifications further EBV- KSHV-mediated cancerogenesis. Both EBV KSHV manipulate DNA methylation, histone modification, chromatin remodeling, interplay elevation oncogene expression silencing tumor suppressor genes. Immune factors also a pivotal role cancer. The have evolved intricate strategies, manipulation major histocompatibility (MHC) release cytokines, allowing infected cells evade detection destruction. In addition, compromised system, HIV/AIDS patients, increases risk cancers associated with KSHV. This review aims provide comprehensive overview genetic, epigenetic, mechanisms drive cancerogenesis, highlighting key molecular pathways potential therapeutic targets.

Language: Английский

Pathogenetic Mechanisms Linking Sarcoidosis to Lymphoma DOI Open Access

Styliani Voutidou,

N. Eleftheriadis, Fotios Drakopanagiotakis

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(2), P. 594 - 594

Published: Jan. 12, 2025

Sarcoidosis and lymphoma share immunopathological characteristics that suggest a complex, interconnected relationship. This article examines the multi-faceted mechanisms linking sarcoidosis to lymphoma, phenomenon called sarcoidosis-lymphoma syndrome (SLS). SLS is hard diagnose, requiring distinct criteria imaging differentiate overlapping features histological differences. The co-occurrence of these diseases may be explained by genetic predispositions, immune dysregulation, environmental factors enhance malignancy risk. In active sarcoidosis, chronic inflammation granuloma formation induce production cytokines can contribute development. role macrophage polarization also discussed. Immunosuppressive treatment prescribed in patients, particularly corticosteroids biological agents, increase susceptibility lymphoproliferative malignancies. These common emphasize need for vigilant monitoring patients with as this granulomatous disease mimic promote development lymphoma.

Language: Английский

Citations

0
Modified Endothelial Activation and Stress Index: A New Predictor for Survival Outcomes in Classical Hodgkin Lymphoma Treated with Doxorubicin-Bleomycin-Vinblastine-Dacarbazine-Based Therapy DOI Creative Commons
Fazıl Çağrı Hunutlu, Hikmet Öztop, Vildan Gürsoy

et al.

Diagnostics, Journal Year: 2025, Volume and Issue: 15(2), P. 185 - 185

Published: Jan. 14, 2025

Background: Although the cure rates of classical Hodgkin Lymphoma (cHL) are as high 90% using current treatment protocols, prognosis is poor for primary refractory patients. Thus, a biomarker that can predict patients with early progression at time diagnosis an unmet clinical need. Endothelial activation and stress index (EASIX) its variant modified EASIX (mEASIX) scoring system currently used prediction in hematologic malignancies. This study aimed to investigate prognostic value mEASIX score newly diagnosed cHL Methods: Data from 206 who underwent positron emission tomography (PET)-guided doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD) therapy between January 2007 November 2023 were retrospectively analyzed. The was evaluated receiver operating characteristic (ROC) analysis, Cox regression Kaplan–Meier method, then compared standard risk assessment methods. Results: median age 33 years, rate advanced stage 67%. ROC analysis determined optimal cut-off 17.28, categorizing into mEASIXhigh (47%) mEASIXlow (53%) groups. 5-year progression-free survival (PFS) (60% vs. 84.3%) overall (OS) (79.6% 95.8%) significantly lower group (p < 0.001). Additionally, multivariate showed independent variables affecting PFS included nodular sclerosing subtype (HR: 0.4), bone marrow involvement 2.6), elevated 3.1). Independent variables, which had effect on OS (HR:3.8) higher IPS-3 scores (HR:1.9). Furthermore, (≥17.28) identified variable indicating disease (OR: 6.5). Conclusions: powerful easy-to-access marker detection cases.

Language: Английский

Citations

0
Predicting 30-day mortality in hemophagocytic lymphohistiocytosis: clinical features, biochemical parameters, and machine learning insights DOI Creative Commons

Jinli Zhu,

Na Cao, Fan Wu

et al.

Annals of Hematology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

This study aims to evaluate the clinical characteristics and biochemical parameters of hemophagocytic lymphohistiocytosis (HLH) patients predict 30-day mortality. Parameters analyzed include lymphocyte count (L), platelet (PLT), total protein (TP), albumin (ALB), blood urea nitrogen (BUN), activated partial thromboplastin time (APTT). Machine learning (ML) approaches, including LASSO, random forest (RF), support vector machine (SVM), were employed alongside meta-analysis sensitivity analysis validate prognostic potential these indicators. A retrospective 151 HLH was conducted identify key predictive variables. Receiver operating characteristic (ROC) analysis, Kaplan-Meier (K-M) survival curves, Cox regression used capabilities parameters. ML algorithms determined optimal cut-off values classify into high-risk low-risk groups. nomogram risk scoring system developed provide individualized assessments. Meta-analysis aggregated data from existing literature further differences in PLT, ALB, APTT between deceased surviving patients. Older age, low L, elevated BUN, prolonged strongly associated with higher mortality Six indicators—TP, APTT, PLT—were identified as critical predictors. ROC K-M analyses highlighted significance The demonstrated high accuracy predicting risk. confirmed significant patients, reinforcing value underscores importance specific By integrating methodologies, a developed, offering valuable tools for early diagnosis, prognosis assessment, personalized treatment planning practice.

Language: Английский

Citations

0
MEPED as salvage therapy for relapsed/refractory Hodgkin’s lymphoma incorporating edited non-oncogene addiction: mTOR as a bottleneck DOI Creative Commons
Dennis Christoph Harrer, Florian Lüke, Tobias Pukrop

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 20, 2025

Rescue therapies of relapsed/refractory (r/r) Hodgkin’s lymphoma (HL) in the third to sixth-line provide major, yet unresolved problems. The MEPED regimen includes nuclear receptor agonists such as pioglitazone and dexamethasone, which counterbalance HL homeostasis, stress response inhibitors, everolimus COX-2 inhibitor, a inducer, low-dose metronomic treosulfan. CR (six seven patients) long-term cCR patients receiving no consolidating allogeneic stem cell transplantation highlight potent salvage therapy advanced refractory HL. edits activities way that mTORC1 becomes non-oncogene addiction bottleneck, hence determining outcome. implications therapeutic paradigm shift toward editing tissue, particularly mTOR addiction, could prove be profound for clinical practice, both terms outcome treatment tolerability. results indicate urgent evaluation schedule multicenter trial r/r

Language: Английский

Citations

0
Tumor-microenvironment and molecular biology of classic Hodgkin lymphoma in children, adolescents, and young adults DOI Creative Commons
Tomohiro Aoki, Kyle Wierzbicki, Suhong Sun

et al.

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: May 1, 2025

Classic Hodgkin lymphoma (cHL) exhibits a bimodal age distribution with incidence peaks in adolescents and young adults (AYAs) aged 15-39 years older over 50 years. The unique biology of cHL, characterized by tumor microenvironment (TME) composed predominantly non-malignant immune stromal cells, plays pivotal role supporting Reed-Sternberg (HRS) the malignant cells cHL. Understanding TME cHL its age-related differences is crucial for deciphering differential disease etiologies developing biomarker-driven targeted therapies. Recent technical advances single-cell sequencing multiplexed spatial imaging have revealed composition function, including key cellular interactions, leading to development age-specific prognostic indicators. In addition, our ability isolate nucleic acids from HRS accelerated understanding molecular alterations many which drive interactions within TME. Molecular between pediatric/AYA adult patients also emerged. This review summarizes children, adolescents, adults, highlighting recent breakthroughs biology, across spectrum, biomarker development.

Language: Английский

Citations

0
Real-world treatment outcomes for Hodgkin lymphoma in South Africa: a prospective observational study DOI Creative Commons

Samantha L Vogt,

Garrick Laudin, Marianna Zahurak

et al.

Infectious Agents and Cancer, Journal Year: 2024, Volume and Issue: 19(1)

Published: Sept. 27, 2024

Language: Английский

Citations

1
Innovative label-free lymphoma diagnosis using infrared spectroscopy and machine learning on tissue sections DOI Creative Commons
Charlotte Delrue, Mattias Hofmans, Jo Van Dorpe

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Oct. 31, 2024

The diagnosis of lymphomas is challenging due to their diverse histological presentations and clinical manifestations. There a need for inexpensive tools that require minimal expertise are accessible routine laboratories. Contrastingly, current conventional diagnostic methods often found only in specialized environments. Attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy offers nondestructive user-friendly approach the analysis wide range samples. In this paper, we determined whether technique coupled with machine learning can detect differentiate lymphoma within lymphoid tissue Tissue sections from 295 individuals diagnosed 389 without disease were analyzed using ATR-FTIR spectroscopy. resulting spectral dataset was split 70:30 train-test split. Partial least Squares Discriminant Analysis (PLS-DA) models trained distinguish non-malignant samples between subtypes. On training set (n = 478), significant differences mainly identified 1800-900 cm

Language: Английский

Citations

1
Lymphadenitis/Reactive-Hyperplasia, Mimickers of Lymphomas, Low-Grade B-Cell Lymphomas, and Hodgkin Lymphoma DOI Creative Commons
Alina Nicolae, Elena Sabattini, Maurilio Ponzoni

et al.

Hemato, Journal Year: 2024, Volume and Issue: 5(3), P. 350 - 379

Published: Sept. 20, 2024

A two-day meeting on controversial topics in hematopathology was held Bologna, Italy, 19–20 January 2024. The primarily targeted pathologists lacking experience hematological neoplasms and training. course aimed to highlight practical diagnostic challenges faced by discuss solutions through the application of conventional histology, along with appropriate immunohistological, genetic, molecular findings. teaching program included lectures slide seminars presented a team expert hematopathologists who were co-authors WHO classification hematolymphoid tumors. Special interest revolved around “lymphadenitis lymphoma mimickers”, “a rational approach low-grade B-cell lymphomas”, “advancements defining Hodgkin lymphoma”. key aspect emphasized faculty use fifth edition Bluebook International Consensus Classification (ICC 2022) lymphomas.

Language: Английский

Citations

0
The ‘Oma’s of the Gammas—Cancerogenesis by γ-Herpesviruses DOI Creative Commons
A K Banerjee, Debashree Dass,

Soumik Mukherjee

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(12), P. 1928 - 1928

Published: Dec. 17, 2024

Epstein–Barr virus (EBV) and Kaposi’s sarcoma-associated herpesvirus (KSHV), which are the only members of gamma(γ) herpesviruses, oncogenic viruses that significantly contribute to development various human cancers, such as Burkitt’s lymphoma, nasopharyngeal carcinoma, Hodgkin’s sarcoma, primary effusion lymphoma. Oncogenesis triggered by γ-herpesviruses involves complex interactions between viral genetics, host cellular mechanisms, immune evasion strategies. At genetic level, crucial oncogenes participate in disruption cell signaling, leading uncontrolled proliferation inhibition apoptosis. These proteins can modulate several pathways, including NF-κB JAK/STAT play essential roles survival inflammation. Epigenetic modifications further EBV- KSHV-mediated cancerogenesis. Both EBV KSHV manipulate DNA methylation, histone modification, chromatin remodeling, interplay elevation oncogene expression silencing tumor suppressor genes. Immune factors also a pivotal role cancer. The have evolved intricate strategies, manipulation major histocompatibility (MHC) release cytokines, allowing infected cells evade detection destruction. In addition, compromised system, HIV/AIDS patients, increases risk cancers associated with KSHV. This review aims provide comprehensive overview genetic, epigenetic, mechanisms drive cancerogenesis, highlighting key molecular pathways potential therapeutic targets.

Language: Английский

Citations

0