Exercise to Prevent and Manage Frailty and Fragility Fractures

Current Osteoporosis Reports, Journal Year: 2023, Volume and Issue: 21(2), P. 205 - 215

Published: March 28, 2023

This review identifies exercise-based recommendations to prevent and manage frailty fragility fractures from current clinical practice guidelines. We also critically assess recently published literature in relation exercise interventions mitigate fractures.

Language: Английский

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Machine Learning and Fuzzy Logic fusion approach for osteoporosis risk prediction

MethodsX, Journal Year: 2025, Volume and Issue: 14, P. 103152 - 103152

Published: Jan. 5, 2025

Language: Английский

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A Comprehensive Exploration of Polymeric 3D Sponges for Regeneration of Bone

Regenerative Engineering and Translational Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Language: Английский

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Osteoporosis in Childhood Cancer Survivors: Physiopathology, Prevention, Therapy and Future Perspectives

Cancers, Journal Year: 2022, Volume and Issue: 14(18), P. 4349 - 4349

Published: Sept. 6, 2022

The improvement of chemotherapy, radiotherapy, and surgical interventions, together with hematopoietic stem cell transplantation, increased childhood cancer survival rate in the last decades, reaching 80% Europe. Nevertheless, anti-cancer treatments are mainly responsible for onset long-term side effects survivors (CCS), including alterations endocrine system function activity. In particular, most frequent dysfunction CCS is a metabolic bone disorder characterized by low mineral density (BMD) skeletal fragility. BMD loss also consequence sedentary lifestyle, malnutrition, itself could affect BMD, thus inducing osteopenia osteoporosis. this paper, we provide an overview possible causes impairment order to propose management strategies early identification treatment fragility population.

Language: Английский

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Potassium: A Frontier in Osteoporosis

Hormone and Metabolic Research, Journal Year: 2024, Volume and Issue: 56(05), P. 329 - 340

Published: Feb. 12, 2024

Abstract Osteoporosis is a significant public health concern, particularly in aging populations, leading to fractures, decreased mobility, and reduced quality of life. While calcium vitamin D have long been recognized as essential for bone health, emerging research suggests that potassium may play crucial role maintaining density preventing osteoporosis. This manuscript explores the relationship between osteoporosis, delving into mechanisms, epidemiological evidence, potential therapeutic implications health. Furthermore, discusses sources dietary potassium, its impact on metabolism, future directions clinical practice regarding potassium’s osteoporosis management.

Language: Английский

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Pharmacological, Nutritional, and Rehabilitative Interventions to Improve the Complex Management of Osteoporosis in Patients with Chronic Obstructive Pulmonary Disease: A Narrative Review

Journal of Personalized Medicine, Journal Year: 2022, Volume and Issue: 12(10), P. 1626 - 1626

Published: Oct. 1, 2022

Osteoporosis is a highly prevalent condition affecting growing number of patients affected by chronic obstructive pulmonary disease (COPD), with crucial implications for risk fragility fractures, hospitalization, and mortality. Several factors have been identified to role in osteoporosis development COPD patients, including corticosteroid therapy, systemic inflammation, smoke, physical activity levels, malnutrition, sarcopenia. In this scenario, personalized multitarget intervention focusing on the pathological mechanisms underpinning mandatory improve bone health these frail patients. Specifically, exercise, nutritional approach, dietary supplements, smoke cessation are cornerstone lifestyle approach improving not only but also performance balance. On other hand, pharmacological treatment should be considered both prevention at higher fractures. Despite considerations, several barriers still affect integration managing However, digital innovation solutions telemedicine might optimizing sustainable networking between hospital assistance community settings reduce sanitary costs long-term management osteoporosis.

Language: Английский

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Fatty infiltration of the multifidus muscle independently increases osteoporotic vertebral compression fracture risk

BMC Musculoskeletal Disorders, Journal Year: 2023, Volume and Issue: 24(1)

Published: June 22, 2023

Vertebral compression fractures decrease daily life activities and increase economic social burdens. Aging decreases bone mineral density (BMD), which increases the incidence of osteoporotic vertebral (OVCFs). However, factors other than BMD can affect OVCFs. Sarcopenia has been a noticeable factor in aging health problem. Sarcopenia, involves quality back muscles, influences Therefore, this study aimed to evaluate influence multifidus muscle on OVCFs.We retrospectively studied patients aged 60 years older who underwent concomitant lumbar MRI university hospital database, with no history structurally affecting spine. We first divided recruited people into control group fracture according presence or absence OVCFs, further an osteoporosis osteopenia based T-score -2.5. Using images spine MRI, cross-sectional area percentage fiber (PMF) were obtained.We included 120 had visited hospital, 45 participants 75 (osteopenia BMD: 41, 34). Age, BMD, psoas index significantly differed between groups. The mean (CSA) muscles measured at L4-5 L5-S1, respectively, did not differ among control, P-BMD, O-BMD On hand, PMF L5-S1 showed significant difference three groups, value was lower that group. Logistic regression analysis value, CSA, affected risk without adjusting for factors.High fatty infiltration spinal risk. preserving is essential preventing

Language: Английский

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Osteosarcopenia in Patients with Chronic Obstructive Pulmonary Diseases: Which Pathophysiologic Implications for Rehabilitation?

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(21), P. 14314 - 14314

Published: Nov. 2, 2022

Chronic obstructive pulmonary disease (COPD) is a burdensome condition affecting growing number of people worldwide, frequently related to major comorbidities and functional impairment. In these patients, several factors might have role in promoting both bone muscle loss, including systemic inflammation, corticosteroid therapies, sedentary behaviours, deconditioning, malnutrition, smoking habits, alcohol consumption. On the other hand, tissues share linkages from functional, embryological, biochemical points view. Osteosarcopenia has been recently defined by coexistence osteoporosis sarcopenia, but precise mechanisms underpinning osteosarcopenia patients with COPD are still unknown. this scenario, deeper understanding molecular basis guide clinicians personalized approach integrating skeletal health rehabilitation framework COPD. Taken together, our results summarized currently available evidence about multilevel interactions between pave way for comprehensive targeting most common risk pathological conditions. Further studies needed clarify modern clinical strategies telemedicine solutions optimize healthcare delivery COPD, osteopenia, osteoporosis, sarcopenia screening subjects.

Language: Английский

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The Role of Consumption of Molybdenum Biofortified Crops in Bone Homeostasis and Healthy Aging

Nutrients, Journal Year: 2023, Volume and Issue: 15(4), P. 1022 - 1022

Published: Feb. 17, 2023

Osteoporosis is a chronic disease and public health issue in aging populations. Inadequate intake of micronutrients increases the risk bone loss during an adult’s lifespan therefore osteoporosis. The aim study was to analyze effects consumption biofortified crops with micronutrient molybdenum (Mo) on remodeling metabolism population adults seniors. trial enrolled 42 senior adult people randomly divided into three groups that consumed lettuce (Mo-biofortified group) or without biofortification (control tablet (Mo-tablet for 12 days. We chose experimental period days because marker levels are influenced short term. Therefore, allows us determine if there changes indicators. Blood samples, obtained at time zero end study, were compared within seniors markers resorption, C-terminal telopeptide (CTX) formation osteocalcin, along metabolism, parathyroid hormone (PTH), calcitonin, albumin-adjusted calcium, vitamin D, phosphate potassium. Consumption Mo did not affect study. Mo-biofortified significantly reduced CTX PTH increased D while potassium affected. opens up new considerations about role nutrition supplementation prevention diseases middle-aged older adults. positively impacts through resorption improved tablets metabolism. may be used as intervention improve homeostasis prevent occurrence osteoporosis elderly.

Language: Английский

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The association between dietary inflammation index and bone mineral density: results from the United States National Health and nutrition examination surveys

Renal Failure, Journal Year: 2023, Volume and Issue: 45(1)

Published: May 8, 2023

To investigate the associations of dietary inflammation index (DII) with bone density and osteoporosis in different femoral areas.The study population was selected from National Health Nutrition Examination Survey (NHANES) exclusion criteria age 18, pregnancy, or missing information on DII, marrow (BMD), estimated glomerular filtration rate (eGFR), urine albumin-to-creatinine ratio (UACR), had diseases which may influence systemic inflammation. DII calculated based questionnaire interview recall within 24 h. Subjects' baseline characteristics were collected. The between areas analyzed.After applying criteria, 10,312 participants included study. Significant differences among tertiles found BMD T scores (p < .001) neck, trochanter, intertrochanter, total femur. High associated low BMDs all (all p .01). Compared to (tertile1, 0.380 as reference), femur, increased is independently possibility presence (OR, 95% CI: 1.88, 1.11-3.20; 2.10, 1.05-4.20; 1.94, 1.02-3.69, respectively). However, this positive association only observed trochanteric area non-Hispanic White after full adjustment 3.22 (1.18, 8.79)). No significant difference subjects without impaired kidney function (eGFR 60 ml/min/1.73 m2).High related declined areas.

Language: Английский

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