Exploration of the Biological Function of Ferroptosis in Bone Nonunion: An Analysis of Bioinformatics Combined Mendelian Randomization

Molecular Biotechnology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Language: Английский

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Association between plain water intake and the risk of osteoporosis among middle-aged and elderly people in the United States: a cross-sectional study

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: March 18, 2025

The connection between plain water intake (PWI) and osteoporosis risk is still unclear. investigation aimed to identify the relationship PWI in middle-aged elderly individuals United States (US). This cross-sectional study was conducted among participants aged 50 years older following waves of National Health Nutrition Examination Survey (NHANES): 2007-2008, 2009-2010, 2013-2014, 2017-2018. examined by multivariable logistic regression models, accompanied subgroup analyses interaction tests. Smooth curve fitting threshold effect analysis were utilized. present included 6,686 participants. In accordance with fully adjusted model, highest tertile had a significantly reduced contrast those lowest [odds ratio (OR) = 0.62; 95% confidence interval (CI): 0.49-0.77; P for trend<0.001]. After adjusting all covariates, higher linked decreased (OR 0.92; CI: 0.86-0.98; p 0.008). No significant interactions detected age, gender, race, body mass index, diabetic history, hypertension status, smoking consumption prednisone or cortisone, moderate strenuous activity (all interaction>0.05). revealed that when less than 1,220 mL/day, there negative 0.79; 0.70-0.89; < 0.001); nevertheless association not greater mL/day 1.06; 0.95-1.17; 0.288). outcomes our indicated US adults, connected moderately risk. Managing might reduce

Language: Английский

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Development and evaluation of a machine learning model for osteoporosis risk prediction in Korean women

BMC Women s Health, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 28, 2025

The aim of this study was to develop a machine learning (ML) model for classifying osteoporosis in Korean women based on large-scale population cohort study. This also aimed assess ML performance compared with traditional screening tools. Furthermore, examine the factors influencing risk through variable importance. Data collected from 4199 aged 40-69 years baseline survey Ansan and Ansung Genome Epidemiology Study. Osteoporosis set as dependent classification models. Independent variables included 122 related risk, such socio-demographic characteristics, anthropometric parameters, lifestyle factors, reproductive nutrient intakes, diet quality indices, medical history, medication family biochemical genetic factors. six models were developed using techniques, including decision tree, random forest, multilayer perceptron, support vector machine, light gradient boosting extreme (XGBoost). two tools, assessment instrument (ORAI) self-assessment tool (OST). performances evaluated confusion matrix area under curve (AUC) metrics. Variable importance assessed XGBoost technique investigate showed highest out models, an accuracy 0.705, precision 0.664, recall 0.830, F1 score 0.738. Moreover, higher AUC than ORAI OST. scores identified 69 associated Age at menopause ranked first Variables arthritis, physical activities, hypertension, education level, income level; alcohol intake, potassium homeostatic insulin resistance; energy vitamin C gout; dietary inflammatory index top 20 variables, technique. found that can be utilized classify women. is significant factor followed by level.

Language: Английский

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Analyses of Antioxidant Properties, Mineral Composition, and Fatty Acid Profiles of Soy-Based Beverages Before and After an In Vitro Digestion Process

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 411 - 411

Published: March 28, 2025

Soy beverages (SB) are the most popular beverage in expanding market of plant-based drinks. They provide high-quality protein and polyphenols often Ca-fortified as a milk alternative. This work evaluated antioxidant potential, mineral content, fatty acid profiles found SB, analysing well bioaccessibility some nutrients after INFOGEST static digestion. Five types SB available market, including Ca-fortified, high-protein, low-fat drinks, were analysed. Ca supplementation high content significantly enhanced bioaccessibility. The lipid profile demonstrated substantial changes during digestion, due to drastic reductions saturated acids marked increases polyunsaturated bioaccessible fractions; these mainly related levels beverages. Significant properties, measured by ABTS FRAP assays, noticed digestive process. Additionally, ROS generation Caco-2 cells induced oxidative damage was prevented BF digested SB. drink, which also had low level showed least activity. In conclusion, composition soy drink considerably affected nutritional components drink’s potential.

Language: Английский

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Small Molecules, Big Impact: Exploring Oxidative Stress, Micronutrients, and Bone Health

Deleted Journal, Journal Year: 2025, Volume and Issue: 23(1)

Published: May 8, 2025

Language: Английский

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Beyond traditional methods: nanomaterials pave the way for precise nutrient detection in nutritionally fortified foods

Critical Reviews in Food Science and Nutrition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 36

Published: May 13, 2025

Detecting trace elements in nutritionally fortified foods is essential for safeguarding public health, as these micronutrients play a critical role various biological processes, including enzyme functionality, cellular metabolism, and the structural integrity of macromolecules; however, current analytical methods are often limited by high operational costs, complex sample preparation, requirement specialized technical expertise. This review highlights transformative potential nanotechnology addressing challenges, showcasing how nanomaterials enhance element detection through specific ligand recognition, oxidation-reduction reactions, adsorption, enzyme-like activities, resonance energy transfer mechanisms. We discuss integration monodentate, bidentate, polydentate ligands nanomaterial-based systems to improve specificity stability, explore implications technologies such surface plasmon (SPR), surface-enhanced Raman scattering (SERS), fluorescence, electrochemical signal, spectral signal advancing capabilities. Incorporating with advanced data processing portable inspection equipment anticipated capabilities, paving way real-time monitoring that fortifies food safety protocols, ensuring quality ultimately contributing improved health outcomes.

Language: Английский

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Nutraceuticals in osteoporosis prevention

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Oct. 2, 2024

Nutraceuticals are gaining popularity as they can contribute to bone health by delaying the onset or slowing down progression of pathological loss. Osteoporosis’s loss is a concern for older adults and crucial aspect aging. Maintaining healthy bones key living full active life. Our review explores current knowledge on role nutraceuticals in preventing osteoporosis focusing three main aspects. First, we provide an overview osteoporosis. Second, discuss latest findings natural their efficacy reducing loss, emphasizing clinical trials. Third, conduct structured analysis evaluate nutraceuticals’ pros cons identify translational gaps. In conclusion, must address several challenges consolidate our knowledge, better support clinicians prescriptions, people with more reliable nutritional recommendations help them lead healthier lives.

Language: Английский

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Structural and biological properties of hydroxyfluorapatite containing sodium and potassium and substituted with carbonates bioceramics for bone tissue engineering

Journal of the Australian Ceramic Society, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 6, 2024

Language: Английский

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