Cancer Cell International,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: Jan. 27, 2025
Theranostics
is
a
way
of
treating
illness
that
blends
medicine
with
testing.
Specific
characteristics
should
be
present
in
the
best
theranostic
agents
for
cancer:
(1)
drugs
safe
and
non-toxic;
(2)
they
able
to
treat
cancer
selectively;
(3)
build
up
only
cancerous
tissue.
Liposomes
(LPs)
are
one
most
efficient
drug
delivery
methods
based
on
nanotechnology.
Stealth
LPs
commercial
have
recently
had
an
impact
treatment.
Using
valuable
information
from
each
imaging
technique,
along
multimodality
functionality
liposomal
therapeutic
agents,
makes
them
very
appealing
personalized
monitoring
how
well
working
against
vivo
predicting
therapies
will
work.
On
other
hand,
their
use
as
nanoparticle
systems
currently
research
development
phase.
Nanoscale
system
innovation
has
made
LP-nanoparticle
hybrid
structures
useful
combining
methods.
LP-hybrid
nanoparticles
better
at
killing
cells
than
LP
counterparts,
making
excellent
options
vitro
applications.
Hybrid
liposomes
(HLs)
could
used
future
carriers
find
targets.
This
would
combine
features
synthetic
biological
systems.
Overarchingly,
this
article
provided
comprehensive
overview
many
types
detection,
therapy,
analysis.
An
evaluation
pros
cons
HLs
detection
treatment
also
been
conducted.
The
study
included
recent
significant
We
conclude
by
outlining
potential
benefits
drawbacks
approach
concurrent
different
malignancies,
its
prospects.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: May 17, 2023
Abstract
Since
the
proposal
of
Paul
Ehrlich’s
magic
bullet
concept
over
100
years
ago,
tremendous
advances
have
occurred
in
targeted
therapy.
From
initial
selective
antibody,
antitoxin
to
drug
delivery
that
emerged
past
decades,
more
precise
therapeutic
efficacy
is
realized
specific
pathological
sites
clinical
diseases.
As
a
highly
pyknotic
mineralized
tissue
with
lessened
blood
flow,
bone
characterized
by
complex
remodeling
and
homeostatic
regulation
mechanism,
which
makes
therapy
for
skeletal
diseases
challenging
than
other
tissues.
Bone-targeted
has
been
considered
promising
approach
handling
such
drawbacks.
With
deepening
understanding
biology,
improvements
some
established
bone-targeted
drugs
novel
targets
deliveries
on
horizon.
In
this
review,
we
provide
panoramic
summary
recent
strategies
based
targeting.
We
highlight
targeting
structure
biology.
For
agents,
addition
classic
denosumab,
romosozumab,
PTH1R
ligands,
potential
process
key
membrane
expressions,
cellular
crosstalk,
gene
expression,
all
cells
exploited.
delivery,
different
matrix,
marrow,
are
summarized
comparison
between
ligands.
Ultimately,
review
will
summarize
translation
therapies
perspective
challenges
application
clinic
future
trends
area.
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
24, P. 100948 - 100948
Published: Jan. 5, 2024
Articular
cartilage
injury
is
a
frequent
worldwide
disease,
while
effective
treatment
urgently
needed.
Due
to
lack
of
blood
vessels
and
nerves,
the
ability
self-repair
limited.
Despite
availability
various
clinical
treatments,
unfavorable
prognoses
complications
remain
prevalent.
However,
advent
tissue
engineering
regenerative
medicine
has
generated
considerable
interests
in
using
biomaterials
for
articular
repair.
Nevertheless,
there
remains
notable
scarcity
comprehensive
reviews
that
provide
an
in-depth
exploration
strategies
applications.
Herein,
we
present
overview
primary
bioactive
substances
from
perspective
repair
cartilage.
The
include
regeneration,
substitution,
immunization.
We
comprehensively
delineate
influence
mechanically
supportive
scaffolds
on
cellular
behavior,
shedding
light
emerging
scaffold
technologies,
including
stimuli-responsive
smart
scaffolds,
3D-printed
bionic
scaffolds.
Biologically
active
substances,
factors,
stem
cells,
extracellular
vesicles
(EVs),
organoids,
are
elucidated
their
roles
regulating
activity
chondrocytes.
Furthermore,
composite
produced
industrially
put
into
use,
also
explicitly
presented.
This
review
offers
innovative
solutions
treating
ailments
emphasizes
potential
translation.
Advanced Drug Delivery Reviews,
Journal Year:
2023,
Volume and Issue:
200, P. 115042 - 115042
Published: Aug. 2, 2023
The
concept
of
using
mRNA
to
produce
its
own
medicine
in
situ
the
body
makes
it
an
ideal
drug
candidate,
holding
great
potential
revolutionize
way
we
approach
medicine.
unique
characteristics
mRNA,
as
well
customizable
biomedical
functions,
call
for
rational
design
delivery
systems
protect
and
transport
molecules.
In
this
review,
a
nanoparticle
toolkit
is
presented
development
mRNA-based
therapeutics
from
perspective.
Nano-delivery
derived
either
natural
or
chemical
synthesis,
nature
organic
inorganic
materials,
are
summarised.
Delivery
strategies
controlling
tissue
targeting
release,
role
nanoparticles
building
boosting
activity
drugs,
have
also
been
introduced.
end,
our
insights
into
clinical
translational
nano-drugs
presented.
Advanced Healthcare Materials,
Journal Year:
2023,
Volume and Issue:
12(18)
Published: March 7, 2023
Abstract
As
the
global
population
ages,
bone‐related
diseases
have
increasingly
become
a
major
social
problem
threatening
human
health.
Exosomes,
as
natural
cell
products,
been
used
to
treat
due
their
superior
biocompatibility,
biological
barrier
penetration,
and
therapeutic
effects.
Moreover,
modified
exosomes
exhibit
strong
bone‐targeting
capabilities
that
may
improve
efficacy
avoid
systemic
side
effects,
demonstrating
promising
translational
potential.
However,
review
of
bone‐targeted
is
still
lacking.
Thus,
recently
developed
for
applications
in
this
are
focused.
The
biogenesis
regulatory
functions
exosomes,
constructive
strategies
bone‐targeting,
effects
introduced.
By
summarizing
developments
challenges
It
striven
shed
light
on
selection
exosome
different
bone
highlight
potential
future
clinical
orthopedics.
Stem Cell Research & Therapy,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: March 29, 2023
Abstract
Mesenchymal
stem
cell-based
therapy
has
become
an
effective
therapeutic
approach
for
bone
regeneration.
However,
there
are
still
limitations
in
successful
clinical
translation.
Recently,
the
secretome
of
mesenchymal
cells,
especially
exosome,
plays
a
critical
role
promoting
repair
and
Exosomes
nanosized,
lipid
bilayer-enclosed
structures
carrying
proteins,
lipids,
RNAs,
metabolites,
growth
factors,
cytokines
have
attracted
great
attention
their
potential
application
regenerative
medicine.
In
addition,
preconditioning
parental
cells
exosome
engineering
can
enhance
exosomes
treating
defects.
Moreover,
with
recent
advancements
various
biomaterials
to
functions
exosomes,
biomaterial-assisted
promising
strategy
This
review
discusses
different
insights
regarding
roles
regeneration
summarizes
applications
as
safe
versatile
agent
delivery
platforms.
The
current
hurdles
transitioning
from
bench
bedside
also
discussed.
Journal of Extracellular Vesicles,
Journal Year:
2024,
Volume and Issue:
13(4)
Published: April 1, 2024
Osteoporosis
(OP)
is
a
systematic
bone
disease
characterized
by
low
mass
and
fragile
microarchitecture.
Conventional
treatment
for
OP
has
limited
efficacy
long-term
toxicity.
Synthetic
biology
makes
bacterial
extracellular
vesicle
(BEVs)-based
therapeutic
strategies
promising
alternative
the
of
OP.
Here,
we
constructed
recombinant
probiotics
Escherichia
coli
Nissle
1917-pET28a-ClyA-BMP-2-CXCR4
(ECN-pClyA-BMP-2-CXCR4),
in
which
BMP-2
CXCR4
were
overexpressed
fusion
with
BEVs
surface
protein
ClyA.
Subsequently,
isolated
engineered
BEVs-BMP-2-CXCR4
(BEVs-BC)
therapy.
The
BEVs-BC
exhibited
great
targeting
vivo.
In
addition,
had
good
biocompatibility
remarkable
ability
to
promote
osteogenic
differentiation
BMSCs.
Finally,
synthetic
biology-based
significantly
prevented
an
ovariectomized
(OVX)
mouse
model.
conclusion,
both
bone-targeting
bone-forming
one-step
using
biology,
provides
effective
strategy
potential
industrialization.
