Covalently Grafted Biomimetic Matrix Reconstructs the Regenerative Microenvironment of the Porous Gradient Polycaprolactone Scaffold to Accelerate Bone Remodeling DOI
Quanying Liu,

Manyu Chen,

Peiyang Gu

et al.

Small, Journal Year: 2023, Volume and Issue: 19(19)

Published: Feb. 11, 2023

Abstract Integrating a biomimetic extracellular matrix to improve the microenvironment of 3D printing scaffolds is an emerging strategy for bone substitute design. Here, “soft–hard” implant (BM‐g‐DPCL) consisting bioactive chemically integrated on polydopamine (PDA)‐coated porous gradient scaffold by polyphenol groups constructed. The PDA‐coated “hard” promoted Ca 2+ chelation and mineral deposition; “soft” beneficial migration, proliferation, osteogenic differentiation stem cells in vitro, accelerated endogenous cell recruitment, initiated rapid angiogenesis vivo. results rabbit cranial defect model (Φ = 10 mm) confirmed that BM‐g‐DPCL integration between tissue induced deposition matrix. Proteomics cytokine adhesion, biomineralization, vascularization, formation are major factors accelerate healing. This highly bonded soft–hard components guided construction regenerative scaffold.

Language: Английский

Osteoimmunity‐Regulating Biomimetically Hierarchical Scaffold for Augmented Bone Regeneration DOI
Jin Zhang,

Dongmei Tong,

Honghai Song

et al.

Advanced Materials, Journal Year: 2022, Volume and Issue: 34(36)

Published: July 4, 2022

Engineering a proper immune response following biomaterial implantation is essential to bone tissue regeneration. Herein, biomimetically hierarchical scaffold composed of deferoxamine@poly(ε-caprolactone) nanoparticles (DFO@PCL NPs), manganese carbonyl (MnCO) nanosheets, gelatin methacryloyl hydrogel, and polylactide/hydroxyapatite (HA) matrix fabricated augment repair by facilitating the balance system metabolism. First, 3D printed stiff with well-organized gradient structure mimics cortical cancellous tissues; meanwhile, an inside infusion soft hydrogel further endows characteristics extracellular matrix. A Fenton-like reaction between MnCO endogenous hydrogen peroxide generated at implant-tissue site triggers continuous release carbon monoxide Mn2+ , thus significantly lessening inflammatory upregulating M2 phenotype macrophages, which also secretes vascular endothelial growth factor induce formation. Through activating hypoxia-inducible factor-1α pathway, DFO@PCL NP promote angiogenesis. Moreover, DFO inhibits osteoclast differentiation synergistically collaborates osteoinductive activity HA. Based on amounts data in vitro vivo, strong immunomodulatory, intensive angiogenic, weak osteoclastogenic, superior osteogenic abilities such osteoimmunity-regulating present profound effect improving regeneration, puts forward worthy base positive enlightenment for large-scale defect repair.

Language: Английский

Citations

240
Recent advances in GelMA hydrogel transplantation for musculoskeletal disorders and related disease treatment DOI Creative Commons
Bin Lv, Lu Li,

Liangcong Hu

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(6), P. 2015 - 2039

Published: Jan. 1, 2023

Increasing data reveals that gelatin has been methacrylated is involved in a variety of physiologic processes are important for therapeutic interventions. Gelatin methacryloyl (GelMA) hydrogel highly attractive hydrogels-based bioink because its good biocompatibility, low cost, and photo-cross-linking structure useful cell survivability monitoring. Methacrylated established itself as typical composition with extensive biomedical applications. Recent advances GelMA have focused on integrating them bioactive functional nanomaterials, the goal improving GelMA's physical, chemical, biological properties. ability to modify characteristics due synthesis technique also makes it choice soft hard tissues. become an independent or supplementary technology musculoskeletal problems. Here, we systematically review mechanism-of-action, uses, challenges future direction disorders. We give overview nanocomposite different applications disorders, such osteoarthritis, intervertebral disc degeneration, bone regeneration, tendon disorders so on.

Language: Английский

Citations

80
Type I collagen decorated nanoporous network on titanium implant surface promotes osseointegration through mediating immunomodulation, angiogenesis, and osteogenesis DOI
Yuyu Zhao, Long Bai, Yi Zhang

et al.

Biomaterials, Journal Year: 2022, Volume and Issue: 288, P. 121684 - 121684

Published: July 20, 2022

Language: Английский

Citations

74
An overview of surface modification, A way toward fabrication of nascent biomedical Ti–6Al–4V alloys DOI Creative Commons
Guijiang Wei,

Meiying Tan,

Shokouh Attarilar

et al.

Journal of Materials Research and Technology, Journal Year: 2023, Volume and Issue: 24, P. 5896 - 5921

Published: April 13, 2023

Language: Английский

Citations

55
Leveraging the Recent Advancements in GelMA Scaffolds for Bone Tissue Engineering: An Assessment of Challenges and Opportunities DOI
Narsimha Mamidi,

Fatemeh Ijadi,

Mohammad Hadi Norahan

et al.

Biomacromolecules, Journal Year: 2023, Volume and Issue: 25(4), P. 2075 - 2113

Published: July 5, 2023

The field of bone tissue engineering has seen significant advancements in recent years. Each year, over two million transplants are performed globally, and conventional treatments, such as grafts metallic implants, have their limitations. Tissue offers a new level treatment, allowing for the creation living within biomaterial framework. Recent advances biomaterials provided innovative approaches to rebuilding function after damage. Among them, gelatin methacryloyl (GelMA) hydrogel is emerging promising supporting cell proliferation regeneration, GelMA exhibited exceptional physicochemical biological properties, making it viable option clinical translation. Various methods classes additives been used application with incorporation nanofillers or other polymers enhancing its resilience functional performance. Despite results, fabrication complex structures that mimic architecture provision balanced physical properties both vasculature growth proper stiffness load bearing remain challenges. In terms utilizing osteogenic additives, priority should be on versatile components promote angiogenesis osteogenesis while reinforcing structure applications. This review focuses efforts advantages GelMA-based composite engineering, covering literature from last five

Language: Английский

Citations

48
Enhancing the Biological Characteristics of Aminolysis Surface-Modified 3D Printed Nanocomposite Polycaprolactone/Nanohydroxyapatite Scaffold via Gelatin Biomacromolecule Immobilization: An In Vitro and In Vivo Study DOI

Mohammadhasan Farnaghi,

Seyed Ali Poursamar, Mahour Farzan

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114505 - 114505

Published: Jan. 9, 2025

Language: Английский

Citations

2
Additive manufacturing for biomedical bone implants: Shaping the future of bones DOI Creative Commons

Muhammad Hassan Razzaq,

Usama Zaheer, Humayun Asghar

et al.

Materials Science and Engineering R Reports, Journal Year: 2025, Volume and Issue: 163, P. 100931 - 100931

Published: Jan. 30, 2025

Language: Английский

Citations

2
An injectable anti-microbial and adhesive hydrogel for the effective noncompressible visceral hemostasis and wound repair DOI
Zheng Chen, Hang Wu, Haibin Wang

et al.

Materials Science and Engineering C, Journal Year: 2021, Volume and Issue: 129, P. 112422 - 112422

Published: Sept. 10, 2021

Language: Английский

Citations

82
Large-pore-size Ti6Al4V scaffolds with different pore structures for vascularized bone regeneration DOI
Chao Wang, Duoling Xu, Ling Lin

et al.

Materials Science and Engineering C, Journal Year: 2021, Volume and Issue: 131, P. 112499 - 112499

Published: Oct. 22, 2021

Language: Английский

Citations

79
Nanoarchitectonics of Cartilage-Targeting Hydrogel Microspheres with Reactive Oxygen Species Responsiveness for the Repair of Osteoarthritis DOI
Yu Han, Chenglong Huang,

Xiangjia Kong

et al.

ACS Applied Materials & Interfaces, Journal Year: 2022, Volume and Issue: 14(36), P. 40711 - 40723

Published: Sept. 5, 2022

Clinically, intra-articular administration can hardly achieve the truly targeted therapy, and drugs are usually insufficient to show local long-term therapeutic effects because of their rapid clearance. Herein, inspired by phenomenon that bees track scent flowers collect nectar, we developed cartilage-targeting hydrogel microspheres with reactive oxygen species (ROS)-responsive ability via combining microfluidic method photopolymerization processes integrate peptides ROS-responsive nanoparticles in matrix. The properties promoted better retention joint cavity enhanced cellular uptake nanoparticles. Moreover, could react osteoarthritis (OA)-induced intracellular ROS, resulting depolymerization nanoparticles, which not only eliminate excess ROS reduce inflammation but also promote release dexamethasone (Dex) kartogenin (KGN) situ, realizing effective OA therapy. It was demonstrated this microsphere showed favorable chondrogenic differentiation as well downregulation pro-inflammatory factors vitro. Additionally, microspheres, similar bees, target effectively repair cartilage model. Thus, injectable exerted an excellent potential may provide avenue for inflammatory bowel disease

Language: Английский

Citations

64