European Polymer Journal, Journal Year: 2024, Volume and Issue: 218, P. 113343 - 113343
Published: July 26, 2024
Language: Английский
Current Issues in Molecular Biology, Journal Year: 2024, Volume and Issue: 46(1), P. 585 - 611
Published: Jan. 5, 2024
Numerous surgeries are carried out to replace tissues that have been harmed by an illness or accident. Due various surgical interventions and the requirement of bone substitutes, emerging field tissue engineering attempts repair damaged with help scaffolds. These scaffolds act as template for regeneration controlling development new cells. For creation functional organs, there three elements play very crucial role: cells, signals achievement these aims, types natural polymers, like chitosan, chitin, cellulose, albumin silk fibroin, used preparation Scaffolds produced from polymers many advantages: they less immunogenic well being biodegradable, biocompatible, non-toxic cost effective. The hierarchal structure bone, microscale nanoscale, is mostly made up organic inorganic components nanohydroxyapatite collagen components. This review paper summarizes knowledge updates information about use scaffolds, their application in recent research trends area (BTE). article extensively explores related analyze advancement nanotechnology treatment bone-related diseases repair.
Language: Английский
Citations
27
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)
Published: June 2, 2024
Abstract Hydrogels are dynamically evolving 3D networks composed of hydrophilic polymer scaffolds with significant applications in the healthcare and environmental sectors. Notably, protein‐based hydrogels mimic extracellular matrix, promoting cell adhesion. Further enhancing proliferation within these matrix‐metalloproteinase‐triggered amino acid motifs. Integration cell‐friendly modules like peptides proteins expands hydrogel functionality. These exceptional properties position for diverse applications, including biomedicine, biosensors, remediation, food industry. Despite progress, there is ongoing research to optimize biomedical further. Engineering novel favorable characteristics crucial regulating tissue architecture facilitating ecological remediation. This review explores synthesis, physicochemical properties, biological implications various types their extensive biomedicine It elaborates on potential bridging gap between advancements sector solutions issues.
Language: Английский
Citations
27
Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2024, Volume and Issue: 151, P. 106391 - 106391
Published: Jan. 9, 2024
Language: Английский
Citations
20
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 1189 - 1204
Published: Feb. 1, 2024
Abstract: Tissue engineering holds great potential for tissue repair and rejuvenation. Plant-derived exosome-like nanoparticles (ELNs) have recently emerged as a promising avenue in engineering. However, there is an urgent need to understand how plant ELNs can be therapeutically applied clinical disease management, especially regeneration. In this review, we comprehensively examine the properties, characteristics, isolation techniques of ELNs. We also discuss their impact on immune system, compatibility with human body, role To ensure suitability engineering, explore various modification strategies. Additionally, provide insights into progress commercialization industrial perspectives This review aims highlight regenerative medicine by exploring current research landscape key findings. Keywords: plant, nanoparticles, nanomedicine, cartilage, wound, bone
Language: Английский
Citations
19
Heliyon, Journal Year: 2024, Volume and Issue: 10(16), P. e36258 - e36258
Published: Aug. 1, 2024
Natural bone tissue has the certain function of self-regeneration and repair, but it is difficult to repair large damage. Recently, although autologous grafting "gold standard" for improving high cost, few donor sources. Besides, allogeneic causes greater immune reactions, which hardly meet clinical needs. The engineering (BTE) been developed promote repair. Gelatin, due its biocompatibility, receives a great deal attention in BTE research field. However, disadvantages natural gelatin are poor mechanical properties single structural property. With development BTE, often used combination with range natural, synthetic polymers, inorganic materials achieve synergistic effects complex physiological process review delves into fundamental structure unique gelatin, as well excellent necessary scaffold materials. Then this explores application modified three-dimensional (3D) scaffolds various structures including 3D fiber scaffolds, hydrogels, nanoparticles. In addition, focuses on efficacy composite consisting or polymeric materials, bioactive ceramics metallic/non-metallic defects. these gelatin-based provides new ideas design good biosafety.
Language: Английский
Citations
14
Biomedicine & Pharmacotherapy, Journal Year: 2025, Volume and Issue: 183, P. 117836 - 117836
Published: Jan. 19, 2025
Language: Английский
Citations
1
Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106789 - 106789
Published: March 1, 2025
Language: Английский
Citations
1
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)
Published: April 22, 2024
Chronic local inflammation and excessive cell apoptosis in nucleus pulposus (NP) tissue are the main causes of intervertebral disc degeneration (IDD). Stimuli-responsive hydrogels have great potential treatment IDD by facilitating localized controlled drug delivery. Herein, an injectable drug-loaded dual stimuli-responsive adhesive hydrogel for microenvironmental regulation IDD, is developed. The gelatin methacryloyl functionalized with phenylboronic acid groups to enhance loading capacity enable behavior, while incorporation oxidized hyaluronic further improves properties. prepared exhibits enhanced diol-containing drugs, pH- reactive oxygen species (ROS)-responsive behaviors, excellent radical scavenging efficiency, potent antibacterial activity, favorable biocompatibility. Furthermore, shows a beneficial protective efficacy on NP cells within vitro oxidative stress microenvironment. vivo results demonstrate hydrogel's therapeutic effect treating maintaining water retention, restoring height, promoting regeneration, indicating that this holds as promising approach regulating microenvironment alleviating progression IDD.
Language: Английский
Citations
7
Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12
Published: Feb. 19, 2024
Introduction: Bone defects remain a thorny challenge that clinicians have to face. At present, scaffolds prepared by 3D printing are increasingly used in the field of bone tissue repair. Polylactic acid (PLA) has good thermoplasticity, processability, biocompatibility, and biodegradability, but PLA is brittle poor osteogenic performance. Beta-tricalcium phosphate (β-TCP) mechanical properties induction properties, which can make up for drawbacks PLA. Methods: In this study, photocurable biodegradable polylactic (bio-PLA) was utilized as raw material prepare PLA/β-TCP slurries with varying β-TCP contents (β-TCP dosage at 0%, 10%, 20%, 30%, 35% dosage, respectively). The were fabricated using liquid crystal display (LCD) light-curing technology. characterization assessed, biological activity scaffold optimal compressive strength evaluated. biocompatibility assessed through CCK-8 assays, hemocompatibility assay live-dead staining experiments. differentiation capacity on MC3T3-E1 cells evaluated alizarin red staining, alkaline phosphatase (ALP) detection, immunofluorescence experiments, RT-qPCR assays. Results: possesses three-dimensional network structure, an increase quantity β-TCP, more particles adhere surface. exhibits trend initial followed decrease increasing amount reaching maximum value 52.1 MPa 10% content. Degradation rate curve results indicate passage time, degradation gradually increases, pH during shows tendency. Additionally, Live/dead blood compatibility experiments suggest demonstrates excellent biocompatibility. group promotes cell proliferation, significant ability enhance vitro . Discussion: printed LCD photocuring could improve surface bioactivity lead better osteogenesis, may provide unique strategy developing bioactive implants orthopedic applications.
Language: Английский
Citations
5
Biofabrication, Journal Year: 2024, Volume and Issue: 16(2), P. 025022 - 025022
Published: Feb. 19, 2024
Versatile and efficient regulation of the mechanical properties extracellular matrix is crucial not only for understanding dynamic changes in biological systems, but also obtaining precise effective cellular responses drug testing. In this study, we developed a well plate-based hydrogel photo-crosslinking system to effectively control hydrogels perform high-throughput assays. We improved cell biocompatibility by using gelatin methacryloyl (GelMA) with visible light method. Multiple cell-laden GelMA were simultaneously uniformly created multi-arrayed 520 nm light-emitting diodes plate format. The elastic modulus can be widely adjusted (0.5-30 kPa) capable independently controlling intensity or exposure time multiple samples. demonstrate feasibility our observing enhanced bone differentiation human mesenchymal stem cells (hMSCs) cultured on stiffer hydrogels. Additionally, observed that osteogenic fate hMSCs, affected different gel, was regulated parathyroid hormone (PTH). Notably, response PTH, hMSCs high-stiffness microenvironment upregulate while exhibiting increased proliferation low-stiffness microenvironment. Overall, enables generation three-dimensional culture models diverse holds significant potential expansion into
Language: Английский
Citations
5