Polymer-Based Hydrogels Applied in Drug Delivery: An Overview

Gels, Journal Year: 2023, Volume and Issue: 9(7), P. 523 - 523

Published: June 27, 2023

Polymer-based hydrogels are hydrophilic polymer networks with crosslinks widely applied for drug delivery applications because of their ability to hold large amounts water and biological fluids control release based on unique physicochemical properties biocompatibility. Current trends in the development hydrogel systems involve drugs response specific triggers such as pH, temperature, or enzymes targeted reduce potential systemic toxicity. In addition, developing injectable formulations that easily used sustain during this extended time is a growing interest. Another emerging trend synthesis nano other functional substances improving loading efficacy. Following these trends, advanced possessing mechanically improved properties, controlled rates, biocompatibility focus field. More complex multi-drug combination therapies will be developed advancements. polymer-based gaining increasing attention personalized medicine tailored patient, example, combinations, target-specific delivery, improvement disease treatment effectiveness, healthcare cost reduction. Overall, application advancing rapidly, towards more efficient effective future.

Language: Английский

---

Additive manufacturing of sustainable biomaterials for biomedical applications

Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(3), P. 100812 - 100812

Published: April 27, 2023

Biopolymers are promising environmentally benign materials applicable in multifarious applications. They especially favorable implantable biomedical devices thanks to their excellent unique properties, including bioactivity, renewability, bioresorbability, biocompatibility, biodegradability and hydrophilicity. Additive manufacturing (AM) is a flexible intricate technology, which widely used fabricate biopolymer-based customized products structures for advanced healthcare systems. Three-dimensional (3D) printing of these sustainable applied functional clinical settings wound dressing, drug delivery systems, medical implants tissue engineering. The present review highlights recent advancements different types biopolymers, such as proteins polysaccharides, employed develop by using extrusion, vat polymerization, laser inkjet 3D techniques addition normal bioprinting four-dimensional (4D) techniques. This also incorporates the influence nanoparticles on biological mechanical performances 3D-printed scaffolds. work addresses current challenges well future developments friendly polymeric manufactured through AM Ideally, there need more focused research adequate blending biodegradable biopolymers achieving useful results targeted areas. We envision that composites have potential revolutionize sector near future.

Language: Английский

---

Recent advances in modified poly (lactic acid) as tissue engineering materials

Journal of Biological Engineering, Journal Year: 2023, Volume and Issue: 17(1)

Published: March 20, 2023

Abstract As an emerging science, tissue engineering and regenerative medicine focus on developing materials to replace, restore or improve organs tissues enhancing the cellular capacity proliferate, migrate differentiate into different cell types specific tissues. Renewable resources have been used develop new materials, resulting in attempts produce various environmentally friendly biomaterials. Poly (lactic acid) (PLA) is a biopolymer known be biodegradable it produced from fermentation of carbohydrates. PLA can combined with other polymers biomaterials suitable physicochemical properties for applications. Here, advances modified as are discussed light its drawbacks, such biological inertness, low adhesion, degradation rate, efforts conducted address these challenges toward design enhanced alternative

Language: Английский

---

Emerging Trends of Nanofibrous Piezoelectric and Triboelectric Applications: Mechanisms, Electroactive Materials, and Designed Architectures

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(26)

Published: March 28, 2024

Abstract Over the past few decades, significant progress in piezo‐/triboelectric nanogenerators (PTEGs) has led to development of cutting‐edge wearable technologies. Nanofibers with good designability, controllable morphologies, large specific areas, and unique physicochemical properties provide a promising platform for PTEGs various advanced applications. However, further nanofiber‐based is limited by technical difficulties, ranging from materials design device integration. Herein, current developments based on electrospun nanofibers are systematically reviewed. This review begins mechanisms advantages nanodevices, including high breathability, waterproofness, scalability, thermal–moisture comfort. In terms structural design, novel electroactive structure assemblies 1D micro/nanostructures, 2D bionic structures, 3D multilayered structures discussed. Subsequently, nanofibrous applications such as energy harvesters, personalized medicine, personal protective equipment, human–machine interactions summarized. Nanofiber‐based still face many challenges efficiency, material durability, stability, Finally, research gap between practical discussed, emerging trends proposed, providing some ideas intelligent wearables.

Language: Английский

---

Immunomodulatory multicellular scaffolds for tendon-to-bone regeneration

Science Advances, Journal Year: 2024, Volume and Issue: 10(10)

Published: March 8, 2024

Limited motor activity due to the loss of natural structure impedes recovery in patients suffering from tendon-to-bone injury. Conventional biomaterials focus on strengthening regenerative ability tendons/bones restore structure. However, owing ignoring immune environment and lack multi-tissue function, satisfactory outcomes remain elusive. Here, combined manganese silicate (MS) nanoparticles with tendon/bone-related cells, immunomodulatory multicellular scaffolds were fabricated for integrated regeneration tendon-to-bone. Notably, by integrating biomimetic cellular distribution MS nanoparticles, exhibited diverse bioactivities. Moreover, enhanced specific differentiation via regulating macrophages, which was mainly attributed secretion PGE2 macrophages induced Mn ions. Furthermore, three animal results indicated that achieved immunomodulation, regeneration, function at interfaces. Thus, based inorganic offer an innovative concept immunomodulation soft/hard tissue

Language: Английский

---

Functional biomaterials for tendon/ligament repair and regeneration

Regenerative Biomaterials, Journal Year: 2022, Volume and Issue: 9

Published: Jan. 1, 2022

Abstract With an increase in life expectancy and the popularity of high-intensity exercise, frequency tendon ligament injuries has also increased. Owing to specificity its tissue, rapid restoration injured tendons ligaments is challenging for treatment. This review summarizes latest progress cells, biomaterials, active molecules construction technology treating tendon/ligament injuries. The characteristics supports made different materials development application manufacturing methods are discussed. natural polymers, synthetic polymers composite boosted use scaffolds. In addition, electrospinning hydrogel diversified production treatment materials. First, this article briefly introduces structure, function biological tendons/ligaments. Then, it advantages disadvantages materials, such as polymer scaffolds, scaffolds extracellular matrix (ECM)-derived regeneration. We then discuss applications electrospun fiber hydrogels regeneration engineering. Finally, we current problems future directions biomaterials restoring damaged ligaments.

Language: Английский

---

Wet-spinnability and crosslinked Fiber properties of alginate/hydroxyethyl cellulose with varied proportion for potential use in tendon tissue engineering

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 240, P. 124492 - 124492

Published: April 17, 2023

Language: Английский

---

Recent Review on Biological Barriers and Host–Material Interfaces in Precision Drug Delivery: Advancement in Biomaterial Engineering for Better Treatment Therapies

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 1076 - 1076

Published: Aug. 16, 2024

Preclinical and clinical studies have demonstrated that precision therapy has a broad variety of treatment applications, making it an interesting research topic with exciting potential in numerous sectors. However, major obstacles, such as inefficient unsafe delivery systems severe side effects, impeded the widespread use medicine. The purpose drug (DDSs) is to regulate time place release action. They aid enhancing equilibrium between medicinal efficacy on target hazardous effects off target. One promising approach biomaterial-assisted biotherapy, which takes advantage biomaterials’ special capabilities, high biocompatibility bioactive characteristics. When administered via different routes, molecules deal biological barriers; DDSs help them overcome these hurdles. With their adaptable features ample packing capacity, biomaterial-based allow for targeted, localised, prolonged medications. Additionally, they are being investigated more controlling interface host tissue implanted biomedical materials. This review discusses innovative nanoparticle designs non-personalised applications improve therapies. We prioritised design trends address heterogeneous barriers, because we believe intelligent can patient outcomes by enabling improving general efficacy. additionally reviewed most recent literature biomaterials used biotherapy vaccine development, covering delivery, stem cell therapy, gene other similar fields; also addressed difficulties future biotherapies.

Language: Английский

---

Effect of adding selected carboxylic acids to the solution on electrophoretic deposition, adhesion strength, morphology and antibacterial properties of chitosan coatings on titanium

Progress in Organic Coatings, Journal Year: 2024, Volume and Issue: 189, P. 108258 - 108258

Published: Jan. 29, 2024

In the presented work, possibility of developing chitosan (CS) coatings on Ti substrates by electrophoretic deposition (EPD) from different acidic solutions was studied. The effect various acids carboxylic acid group used in EPD structure and properties investigated. Two were chosen that had already been to prepare solutions: acetic (HOAc) citric (CiA). addition, malic (MaA) investigated as a novel potential biodegradable natural ingredient. Homogeneous with high adhesion strength obtained, regardless used. showed roughness higher than uncoated substrate. It found alpha-hydroxy (AHAs, CiA MaA) not only protonate amino groups but also change its structure, through proposed cross-linking mechanism. This reflected surface wettability coatings. For obtained solution HOAc, contact angle about 80° for those developed MaA CiA, it 50°. Microbiological studies revealed deposited containing HOAc highest bactericidal activity.

Language: Английский

---

Emerging materials and technologies for advancing bioresorbable surgical meshes

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 184, P. 1 - 21

Published: June 14, 2024

Surgical meshes play a significant role in the treatment of various medical conditions, such as hernias, pelvic floor issues, guided bone regeneration, and wound healing. To date, commercial surgical are typically made non-absorbable synthetic polymers, notably polypropylene polytetrafluoroethylene, which associated with postoperative complications, infections. Biological meshes, based on native tissues, have been employed to overcome though mechanical strength has main disadvantage. The right balance biological performances achieved by advent bioresorbable meshes. Despite improvements, recurrence clinical complications raises concerns regarding technical adequacy current materials designs, pointing crucial need for further development. this end, research focuses design capable biomimicking tissue facilitating healing process without post-operative complications. Researchers actively investigating advanced materials, both natural biopolymers, while also exploring performance therapeutic agents, surface modification methods manufacturing technologies 4D printing. This review seeks evaluate emerging biomaterials enhancing applicability next-generation In ever-transforming landscape regenerative medicine, embracement engineered bioabsorbable stands key borderline addressing persistent challenges existing treatments. urgency move beyond conventional fraught post-surgery emphasises necessity using regeneration. critically examines growing field absorbable considering their potential transform practice. By strategically marrying characteristics, these innovative hold promise mitigating improving patient outcomes across diverse applications. As we navigate complexities exploration emerges light hope, offering an overall perspective biomaterials, technologies, strategies adopted redefine future

Language: Английский

---