International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(9), P. 4242 - 4242
Published: April 29, 2025
Bone
defects
caused
by
various
traumas
and
diseases
such
as
osteoporosis,
which
affects
bone
density,
osteosarcoma,
the
integrity
of
structure,
are
now
well
known.
Given
this
situation,
several
innovative
research
projects
have
been
reported
to
improve
orthopedic
methods
technologies
that
positively
contribute
regeneration
affected
tissue,
representing
a
significant
advance
in
regenerative
medicine.
This
review
article
comprehensively
analyzes
transition
from
existing
for
implants
tissue
biomaterials.
These
biomaterials
great
interest
last
decade
due
their
physicochemical
characteristics,
allow
them
overcome
most
common
limitations
traditional
grafting
methods,
availability
risk
rejection
after
application
could
be
achieved
through
an
exhaustive
study
applications
properties
materials
with
potential
medicine,
using
magnetic
nanoparticles
hydrogels
sensitive
external
stimuli,
including
pH
temperature.
In
regard,
describes
relevant
compounds
used
regeneration,
promoting
integration
these
area's
thereby
allowing
preventing
amputation.
Additionally,
types
interactions
between
mesenchymal
stem
cells
effects
on
discussed,
is
critical
developing
optimal
properties.
Furthermore,
mechanisms
action
enhance
osteoconduction
osteoinduction,
ensuring
success
therapies,
analyzed.
enables
treatment
tailored
each
patient's
condition,
avoiding
limb
Consequently,
promising
future
medicine
emerging,
therapies
revolutionize
management
defects,
offering
more
efficient
safer
solutions.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: July 27, 2024
Materials
used
for
orthopedic
implants
should
not
only
have
physical
properties
close
to
those
of
bones,
durability
and
biocompatibility,
but
also
exhibit
a
sufficient
degree
antibacterial
functionality.
Due
its
excellent
properties,
titanium
is
still
widely
material
production
implants,
the
unmodified
exhibits
poor
activity.
In
this
work,
physicochemical
characteristics,
such
as
chemical
composition,
crystallinity,
wettability,
roughness,
release
Ti
ions
surface
modified
with
nanotubular
layers
were
analyzed
activity
against
two
biofilm-forming
bacterial
strains
responsible
prosthetic
joint
infection
(Staphylococcus
aureus
Pseudomonas
aeruginosa)
was
investigated.
Electrochemical
anodization
(anodic
oxidation)
prepare
types
arrays
nanotubes
differing
in
dimensions
(with
diameters
73
118
nm
lengths
572
343
nm,
respectively).
These
showed
similar
chemistry,
energy.
The
smaller
nanotube
diameter
(TNT-73)
larger
values
roughness
parameters
more
effective
S.
aureus.
For
P.
aeruginosa
sample
(TNT-118)
had
better
effect
proven
cell
lysis.
Antibacterial
surfaces
potential
implantology,
which
our
previous
work
demonstrated
positive
on
behavior
human
gingival
fibroblasts,
investigated
terms
parameters.
interplay
between
appeared
critical
fate
surfaces.
relationship
diameter,
parameters,
other
discussed
detail.
study
believed
shed
light
how
their
affect
