3D and 4D printing hydroxyapatite-based scaffolds for bone tissue engineering and regeneration

Heliyon, Journal Year: 2023, Volume and Issue: 9(9), P. e19363 - e19363

Published: Aug. 22, 2023

The osseous tissue can be classified as a nanocomposite that encompasses complex interweaving of organic and inorganic matrices. This intricate amalgamation consists collagen component mineral phase are intricately arranged to form elaborate perforated configurations. Hydroxyapatite, whether synthesized artificially or obtained from natural sources, has garnered considerable attention composite material in the field bone engineering due its striking resemblance terms structure characteristics. Hydroxyapatite (HA) constitutes predominant ceramic biomaterial for biomedical applications ability replicate composition vertebrate bone. Nonetheless, it is noteworthy present biomimetic substance exhibits unfavorable mechanical characteristics, characterized by insufficient tensile compressive strength, thus rendering unsuitable effective employment engineering. Due beneficial attributes, hydroxyapatite frequently employed conjunction with various polymers crosslinkers composites enhance properties overall efficacy implantable biomaterials engineered. restoration skeletal defects through use customized replacements an way replace damaged lost structures. method not only restores bones' original functions but also reinstates their initial aesthetic appearance. utilization hydroxyapatite-polymer within 3D-printed grafts necessitates meticulous optimization both biological properties, order ensure suitability medical devices. 3D-printing technology represents innovative approach manufacturing HA-based scaffolds, which offers advantageous prospects personalized regeneration. expeditious prototyping method, emphasis on application 3D printing, presents viable development bespoke prosthetic implants, grounded healthcare data sets. 4D printing evolved utilizes programmable materials capable altering intended shape printed structures, contingent upon single dual stimulating factors. These factors include aspects such pH level, temperature, humidity, crosslinking degree, leaching

Language: Английский

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Research Progress in 3D Printed Biobased and Biodegradable Polyester/Ceramic Composite Materials: Applications and Challenges in Bone Tissue Engineering

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: 17(2), P. 2791 - 2813

Published: Jan. 6, 2025

Transplantation of bone implants is currently recognized as one the most effective means treating defects. Biobased and biodegradable polyester composites combine good mechanical degradable properties polyester, thereby providing an alternative for implant materials. Bone tissue engineering (BTE) accelerates defect repair by simulating microenvironment. Composite scaffolds support formation further accelerate process repair. The introduction 3D printing technology enables preparation to be more precise, reproducible, flexible, which a very promising development. This review presents physical BTE summarizes strategies adopted domestic international scholars improve based on biobased polyester/ceramic in recent years. In addition, future development prospects field challenges expanding production clinical applications are presented.

Language: Английский

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The Future of Bone Repair: Emerging Technologies and Biomaterials in Bone Regeneration

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12766 - 12766

Published: Nov. 27, 2024

Bone defects and fractures present significant clinical challenges, particularly in orthopedic maxillofacial applications. While minor bone may be capable of healing naturally, those a critical size necessitate intervention through the use implants or grafts. The utilization traditional methodologies, encompassing autografts allografts, is constrained by several factors. These include potential for donor site morbidity, restricted availability suitable donors, possibility immune rejection. This has prompted extensive research field tissue engineering to develop advanced synthetic bio-derived materials that can support regeneration. optimal substitute must achieve balance between biocompatibility, bioresorbability, osteoconductivity, osteoinductivity while simultaneously providing mechanical during process. Recent innovations three-dimensional printing, nanotechnology, bioactive coatings create scaffolds mimic structure natural enhance cell proliferation differentiation. Notwithstanding advancements above, challenges remain optimizing controlled release growth factors adapting various contexts. review provides comprehensive overview current materials, focusing on their biological mechanisms, design considerations, It explores role emerging technologies, such as additive manufacturing stem cell-based therapies, advancing field. Future highlights need multidisciplinary collaboration rigorous testing graft substitutes, improving outcomes quality life patients with complex defects.

Language: Английский

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Self-sacrificing template synthesis of ultralight porous hydroxyapatite microtube-based ceramics for hemoglobin adsorption

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 492, P. 152404 - 152404

Published: May 20, 2024

Language: Английский

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Surface Coating of Hydroxyapatite/Antibiotics Composite Layer onto Polyetheretherketone for the Improvement of Antibacterial and Bone Cell Growth Activities

Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 106625 - 106625

Published: May 1, 2025

Language: Английский

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Aloe vera mucilage loaded gelatin electrospun fibers contained in polylactic acid coaxial system and polylactic acid and poly(e-caprolactone) tri-layer membranes for tissue engineering

Bio-Medical Materials and Engineering, Journal Year: 2024, Volume and Issue: 35(4), P. 387 - 399

Published: July 5, 2024

BACKGROUND: Polymeric electrospun mats have been used as scaffolds in tissue engineering for the development of novel materials due to its characteristics. The usage synthetic has gone decline environmental problems associated with their synthesis and waste disposal. Biomaterials such biopolymers recently good compatibility on biological applications sustainability. OBJECTIVE: purpose this work is obtain based natural polymers engineering. METHODS: Aloe vera mucilage was obtained, chemically characterized, an active compound contained mats. were obtained single, coaxial tri-layer structures, characterized evaluated cell culture. RESULTS: Mucilage loaded fibers showed formation hydrogen bonds between biomolecules from structure, evidenced by FTIR spectra thermal properties. Cell viability test that most result higher than 75%, resulting nontoxic materials, ready be scaffolding applications. CONCLUSION: containing resulted potential use mechanical performance results.

Language: Английский

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Improvements of Antibacterial and Cell Growth Activities for Hydroxyapatite Rods Modified Polyetheretherketone (PEEK) Implants with Direct Absorption of Antibiotics

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 10, 2024

Demands of bone regeneration and fracture repairing technologies have become increasingly important due to aged society limitation autologous graft. Heterogeneous implants are always employed in clinical treatments but their antibacterial properties, biocompatibilities, the mismatch elastic moduli with human bones be improved. Therefore, polyetheretherketone (PEEK)/ hydroxyapatite (HA) rod-like array samples were manufactured using hydrothermal method then directly attached various types Ampicillin, Vancomycin salts mixture onto HA arrays order improve properties biocompatibility. Various ratios ethylenediaminetetraacetic agent : calcium ions solution baths set obtain high values specific area rods for loading antibiotics. The surface sample prepared ratio 1:1 bath showed largest value. Samples through direct absorption antibiotics can maintain activities up 10 days. Sample (C) (direct Ampicillin + salt (w/w = 50/50)) good inhibition on E. coli S. aureus. Cell growth activity MC3T3-E1 PEEK/HA/antibiotic also better performance than that HA/PEEK sample, suggesting potential application polymer-made implants.

Language: Английский

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Could CH3-M6P Be a Potential Dual-Functioning Candidate for Bone Regeneration?

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2697 - 2697

Published: Nov. 26, 2024

Background: CI-RM6P has different binding sites with affinities for both M6P and IGF2, plays a role in the regulation of TGF-β IGF pathways that is important controlling cell growth differentiation. We hypothesize previously synthesised derivative could be an alternative candidate bone tissue regeneration terms higher affinity, stability human serum, low cost temporal delivery. Methods: CH3-M6P based on described protocol; mesenchymal origin isolated DPSCs was assessed by flow cytometry AR staining prior to alkaline phosphatase (ALP) activity test, qPCR evaluate differentiation specific marker expression, immunofluoresence, SEM/EDS organic inorganic matrix formation; rat aortic ring model angiogenic effect molecule. Results: upregulated ALP activity, expression ALP, Col1, RunX2, Mef2C, TGFβ1, TGFβ1R, TGFβ2, Smad3 genes under osteogenic conditions. The results immunofluorescence studies did not show enhancing formation. As we observed, induction such as SMAD3 even conditions, within scope research, checked molecule compared it VEGF, showing really angiogenic. Conclusions: Our findings provide clue further exploration molecule, which can necessary enhance capability commonly used osteomedium, possibly leading development bone-forming drugs potential dual-functioning engineering.

Language: Английский

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Biological Evaluation of Poly(L-lactide)-Based Fibrous Coatings for Titanium Implant

Published: Nov. 28, 2024

Language: Английский

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