The Era of Biomaterials: Smart Implants?

ACS Applied Bio Materials, Journal Year: 2023, Volume and Issue: 6(8), P. 2982 - 2994

Published: July 12, 2023

Conditions, accidents, and aging processes have brought with them the need to develop implants higher technology that allow not only replacement of missing tissue but also formation recovery its function. The development is due advances in different areas such as molecular-biochemistry (which allows understanding molecular/cellular during repair), materials engineering, regeneration has contributed knowledge properties used for their manufacture), so-called intelligent biomaterials promote through inductive effects cell signaling response stimuli from microenvironment generate adhesion, migration, differentiation processes). currently are combinations biopolymers scaffolds capacity mimic characteristics be repaired. This review describes applied dental orthopedic problems; by means these advances, it expected overcome limitations additional surgeries, rejections infections implants, implant duration, pain mitigation, mainly, regeneration.

Language: Английский

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Silk Fibroin/ZnO Coated TiO2 Nanotubes for Improved Antimicrobial Effect of Ti Dental Implants

Materials, Journal Year: 2023, Volume and Issue: 16(17), P. 5855 - 5855

Published: Aug. 26, 2023

The aim of the present research is to develop a novel hybrid coating for Ti dental implant that combines nature-inspired biomimetic polymers and TiO2 nanostructures with an entrapped ZnO antimicrobial agent. was used in other studies cover surface or Ti-Zr reduce need clinical antibiotics, prevent onset peri-implantitis, increase success rate oral implantation. We developed original represents promising approach dentistry. titanium first anodized obtain nanotubes (NT). Subsequently, on NT surface, silk fibroin isolated from Bombyx mori cocoons deposited as nanofibers using electrospun technique. For improved antibacterial effect, nanoparticles were incorporated this biopolymer three different methods. properties newly created coatings assessed establish how they are influenced by most important features: morphology, wettability, topography. evaluation stability electrochemical methods simulated physiological solutions discussed more detail, considering it could bring necessary information related behavior material. All samples had roughness hydrophilicity, well corrosion (with protection efficiency over 80%). test shows functional has good activity because can inhibit proliferation Staphylococcus aureus up 53% Enterococcus faecalis 55%. modified have proven superior compared unmodified TiNT, which proved potential be material

Language: Английский

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Preservation Strategies for Interfacial Integrity in Restorative Dentistry: A Non-Comprehensive Literature Review

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(2), P. 42 - 42

Published: Jan. 26, 2025

The preservation of interfacial integrity in esthetic dental restorations remains a critical challenge, with hybrid layer degradation being primary factor restoration failure. This is driven by combination host-derived enzymatic activity, including matrix metalloproteinases (MMPs), bacterial proteases, and hydrolytic breakdown the polymerized adhesive due to moisture exposure. review examines multifactorial mechanisms underlying presents current advancements restorative materials aimed at counteracting these effects. Principal strategies include collagen through inhibition integration antimicrobial agents limit biofilm formation, use ester-free, hydrolysis-resistant polymeric systems. Recent research highlights acrylamide-based adhesives, which exhibit enhanced resistance acidic environments, as well dual functionality stabilization. Furthermore, innovations bioactive resins self-healing present promising future directions for developing adhesives that actively contribute long-term stability. These findings underscore importance continuous technology enhance durability clinical performance restorations.

Language: Английский

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Dentistry Insights: Single-Walled and Multi-Walled Carbon Nanotubes, Carbon Dots, and the Rise of Hybrid Materials

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(3), P. 110 - 110

Published: March 20, 2025

We are committed to writing this narrative review given that carbon-based nanomaterials revolutionizing dental medicine. Since the groundbreaking discovery of carbon nanotubes in 1991, their applications have skyrocketed. The numbers speak for themselves: 2024, global market hit USD 1.3 billion and is set double 2.6 by 2029. Over past few decades, various forms been integrated into practices, elevating quality effectiveness treatments. They represent a transformative advancement dentistry, offering numerous benefits such as augmented mechanical properties, antimicrobial activity, potential regenerative applications. Both (CNTs) dots (CDs) derived from integral nanotechnology, showcasing versatility nanostructures delivering cutting-edge solutions across diverse domains, electronics, materials science, biomedicine. CNTs ambitiously examined capability reinforce materials, develop biosensors detecting oral diseases, even deliver therapeutic agents directly affected tissues. This synthesizes current applications, underscores interdisciplinary value bridging nanotechnology identifies key barriers clinical adoption, discusses hybrid strategies warranting further research advance implementation.

Language: Английский

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Biomimetic organomineral layers with antibacterial properties based on di/tetrahydroquinolinediol and nanocrystalline hydroxyapatite deposited on enamel surface

Biomaterials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The paper proposes a strategy for the accelerated deposition of biomimetic organomineral layers on surface dental enamel, utilizing di/tetrahydroquinolinediol (hydroxyquinoline) polymerized in presence nanocrystalline hydroxyapatite (nano-cHAp). mechanisms underlying formation coatings were elucidated through combination structural, microstructural, and spectroscopic analytical methods, including synchrotron infrared nanoimaging. Additionally, antimicrobial effects these investigated. It has been demonstrated that an layer, based dihydroxyquinoline, natural enamel leads to agglomeration orientation nanocrystals within coating. This process enables layer replicate mechanical properties resulting microhardness value closely resembles enamel. Using s-SNOM, it established possesses morphological structure poly(2,2,4-trimethyl-1,2-dihydroquinoline-6,7-diol (TMDHQ))/nano-cHAp composite film, which is homogeneously distributed tightly packed surface. Furthermore, coating formed from polydihydroxyquinoline exhibits inhibitory activity against colonies Streptococcus spp. developed technology layers, exhibit simultaneous antibacterial mineralizing effects, holds significant potential future clinical applications.

Language: Английский

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