International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134752 - 134752
Published: Aug. 30, 2024
Language: Английский
Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)
Published: April 2, 2024
Abstract Cancer immunotherapy and vaccine development have significantly improved the fight against cancers. Despite these advancements, challenges remain, particularly in clinical delivery of immunomodulatory compounds. The tumor microenvironment (TME), comprising macrophages, fibroblasts, immune cells, plays a crucial role response modulation. Nanoparticles, engineered to reshape TME, shown promising results enhancing by facilitating targeted These nanoparticles can suppress fibroblast activation, promote M1 macrophage polarization, aid dendritic cell maturation, encourage T infiltration. Biomimetic further enhance increasing internalization agents cells such as cells. Moreover, exosomes, whether naturally secreted body or bioengineered, been explored regulate TME immune-related affect cancer immunotherapy. Stimuli-responsive nanocarriers, activated pH, redox, light conditions, exhibit potential accelerate co-application with checkpoint inhibitors is an emerging strategy boost anti-tumor immunity. With their ability induce long-term immunity, nanoarchitectures are structures development. This review underscores critical overcoming current driving advancement modification.
Language: Английский
Citations
135
Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(7), P. 103981 - 103981
Published: April 16, 2024
Language: Английский
Citations
65
Advanced Science, Journal Year: 2024, Volume and Issue: 11(22)
Published: March 23, 2024
Abstract Lipid nanoparticles (LNPs) exhibit remarkable mRNA delivery efficiency, yet their majority accumulate in the liver or spleen after injection. Tissue‐specific can be achieved through modulating LNP properties, such as tuning PEGylation varying lipid components systematically. In this paper, a streamlined method is used for incorporating tumor‐targeting peptides into LNPs; programmed death ligand 1 (PD‐L1) binding are conjugated to PEGylated lipids via copper‐free click reaction, and directly incorporated composition (Pep LNPs). Notably, Pep LNPs display robust interaction with PD‐L1 proteins, which leads uptake of overexpressing cancer cells both vitro vivo. To evaluate anticancer immunotherapy mediated by restoring tumor suppressor, encoding phosphatase tensin homolog (PTEN) delivered PTEN‐deficient triple‐negative breast cancers (TNBCs). loaded PTEN specifically promotes autophagy‐mediated immunogenic cell 4T1 tumors, resulting effective immune responses. This study highlights potential tumor‐targeted mRNA‐based therapy.
Language: Английский
Citations
19
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 378, P. 1061 - 1079
Published: Jan. 5, 2025
Language: Английский
Citations
2
ChemBioChem, Journal Year: 2024, Volume and Issue: 25(10)
Published: March 29, 2024
Abstract Peptides have become an indispensable tool in engineering of multifunctional nanostructure platforms for biomedical applications such as targeted drug and gene delivery, imaging biosensing. They can be covalently incorporated into a variety nanoparticles (NPs) including polymers, metallic nanoparticles, others. Using different bioconjugation techniques, peptide‐modified NPs formulated to produce therapeutical diagnostic offering high specificity, lower toxicity, biocompatibility, stimuli responsive behavior. Targeting peptides direct the specific tissues delivery due their specificity towards certain receptors. Furthermore, stimuli‐responsive features, they offer controlled release therapeutics desired sites disease. In addition, peptide‐based biosensors agents provide non‐invasive detection monitoring diseases cancer, infectious diseases, neurological disorders. this review, we covered design formulation recent NP platforms, well utilization vitro vivo targeting, sensing, applications. end, provided future outlook new peptide conjugated nanomaterials
Language: Английский
Citations
15
ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(7), P. 7289 - 7299
Published: March 28, 2024
The tumor microenvironment is distinguished from normal tissues, such as the acidic microenvironment, elevated reactive oxygen species (ROS) levels, and overexpressed specific receptors on cell surface. According to these unique hallmarks of cancer, stimulus-responsive drug carriers can be designed for targeted anticancer delivery release in tissues. Herein, a folate-modified pH/ROS dual-responsive polymeric micellar nanosystem was developed doxorubicin (DOX). profile suggested sustained micelles an accelerated at lower pH higher ROS levels. cellular uptake assay indicated that were internalized by HepG2 cells enhanced folate modification through receptor-mediated endocytosis pathway. Furthermore, nanocarriers demonstrated inhibition migration scratch test showed improved suppression proliferation IC50 than nonfolate viability test, indicating desirable vitro efficiency nanosystem.
Language: Английский
Citations
9
ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 10, 2025
Immunotherapy is a cutting-edge approach that leverages sophisticated technology to target tumor-specific antibodies and modulate the immune system eradicate cancer enhance patients' quality of life. Bioinformatics genetic science advancements have made it possible diagnose treat patients using immunotherapy technology. However, current immunotherapies against limited clinical benefits due cancer-associated antigens, which often fail interact with cells exhibit insufficient therapeutic targeting unintended side effects. To surmount this challenge, nanoparticle systems emerged as potential strategy for transporting immunotherapeutic agents activating combat tumors. Consequently, process potentially generates an antigen-specific T response effectively suppresses growth. Furthermore, nanoplatforms high specificity, efficacy, diagnostic potential, imaging capabilities, making them promising tools treatment. informative paper delves into various available immunotherapies, including CAR therapy checkpoint blockade, cytokines, vaccines, monoclonal antibodies. concept theragnostic nanotechnology, integrates diagnostics more personalized treatment therapy. Additionally, covers different nanocarrier systems, marketed products, trials, regulatory considerations, future prospects immunotherapy.
Language: Английский
Citations
1
Small, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 16, 2025
Abstract The field of immunotherapeutics is rapidly evolving with the advent cell therapies, complex biologics, and a host other compounds. Polymeric carriers are often used to tune safety efficacy profiles these novel drugs. Despite their prevalence in pre‐clinical clinical applications, non‐degradable materials present delivery challenges including diffusion‐limited release, frustrated phagocytosis, limited clearance. In contrast, biodegradable polymeric systems provide safer alternative addition displaying advantageous properties for immunotherapies. this review, discussion polymers poly(lactic‐co‐glycolic acid) (PLGA), poly(beta‐amino esters) (PBAEs), acetalated dextran (Ace‐DEX), chitosan, alginate, hyaluronic acid (HA) as immunomodulatory biomaterial suggest that variety can be generate tailored formulations different therapeutic payloads disease indications. These carrier enhance immunotherapies via tunable degradation rates, enhanced antigen‐presentation, inherent biomaterials, among mechanisms. Polymers formulated applications synthetic, semi‐synthetic, or naturally derived. Therefore, it crucial consider environmental impact polymer sources, particle fabrication methods, solvent usage sustainably develop effective therapies field.
Language: Английский
Citations
1
ACS Nano, Journal Year: 2024, Volume and Issue: 18(2), P. 1690 - 1701
Published: Jan. 2, 2024
The combination of immune checkpoint blockade (ICB) and chemotherapy has shown significant potential in the clinical treatment various cancers. However, circulating regeneration PD-L1 within tumor cells greatly limits efficiency chemo-immunotherapy consequent patient response rates. Herein, we report synthesis a nanoparticle-based inhibitor (FRS) with rational design for effective endogenous suppression. nanoinhibitor is achieved through self-assembly fluoroalkylated competitive peptides that target palmitoylation. FRS nanoparticles provide efficient protection delivery functional to cytoplasm tumors, showing greater inhibition than nonfluorinated peptidic inhibitors. Moreover, demonstrate synergizes chemotherapeutic doxorubicin (DOX) boost antitumor activities via simultaneous reduction abundance induction immunogenic cell death murine colon models. nano strategy regulation present this study expected advance development ICB inhibitors overcome limitations conventional ICB-assisted chemo-immunotherapy.
Language: Английский
Citations
8
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 8373 - 8400
Published: Aug. 1, 2024
Despite all major advancements in drug discovery and development the pharmaceutical industry, cancer is still one of most arduous challenges for scientific community. The implications nanotechnology have certainly resolved issues related to conventional anticancer modalities; however, undesired recognition nanoparticles (NPs) by mononuclear phagocyte system (MPS), their poor stability biological fluids, premature release payload, low biocompatibility restricted clinical translation. In recent decades, chitosan (CS)-based nanodelivery systems (eg, polymeric NPs, micelles, liposomes, dendrimers, conjugates, solid lipid nanoparticles, etc.) attained promising from researchers improving pharmacokinetics pharmacodynamics chemotherapeutics. However, specialty this review mainly focus on critically discuss targeting potential various CS-based NPs treatment different types cancer. Based delivery mechanisms, we classified into stimuli-responsive, passive, or active nanosystems. Moreover, functionalization strategies grafting with polyethylene glycol (PEG), hydrophobic substitution, tethering stimuli-responsive linkers, conjugation ligands) adapted architecture CS-NPs target-specific chemotherapeutics also been considered. Nevertheless, based therapeutics hold great promise therapeutic outcomes while mitigating off-target effects chemotherapeutics, a long-term safety profile testing humans are warranted successful
Language: Английский
Citations
7