Prognostic models of immune-related cell death and stress unveil mechanisms driving macrophage phenotypic evolution in colorectal cancer DOI Creative Commons
Hao Liu, Chuhan Zhang,

Sanfei Peng

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 28, 2025

Tumor microenvironment (TME), particularly immune cell infiltration, programmed death (PCD) and stress, has increasingly become a focal point in colorectal cancer (CRC) treatment. Uncovering the intricate crosstalk between these factors can enhance our understanding of CRC, guide therapeutic strategies, improve patient prognosis. We constructed an immune-related stress (ICDS) prognostic model utilizing machine learning methodologies. Furthermore, we performed enrichment analyses deconvolution algorithms to elucidate complex interactions infiltration processes PCD within substantial array transcriptomic data from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus base (GEO) related CRC. Single-cell sequencing biochemical experiments were used validate interaction genes tumor cells. ICDS exhibited robust predictive performance seven independent cohorts, revealing inverse correlation scores Meanwhile, index was positively correlated with clinical stage. Model analysis indicated that subgroups low heightened activation features elevated activity pathways. further revealed macrophages central drivers characteristics underlying differences model. Pseudotime cellular gene GAL3ST4 promotes transition toward M2 pro-tumor phenotype. communication experimental validation cuproptosis cells suppress expression, thereby inhibiting M2-like macrophage polarization. In summary, uncovered mechanism by which downregulate expression via inhibit polarization, providing new targets biomarkers for CRC treatment prognosis evaluation.

Language: Английский

Chitosan- and hyaluronic acid-based nanoarchitectures in phototherapy: Combination cancer chemotherapy, immunotherapy and gene therapy DOI
Zheng Wang,

Shuo Pang,

Xiaoli Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132579 - 132579

Published: May 23, 2024

Language: Английский

Citations

35
Versatile function of NF-ĸB in inflammation and cancer DOI Creative Commons
Qiang Ma, Shuai Hao, Weilong Hong

et al.

Experimental Hematology and Oncology, Journal Year: 2024, Volume and Issue: 13(1)

Published: July 16, 2024

Abstract Nuclear factor-kappaB (NF-ĸB) plays a crucial role in both innate and adaptive immune systems, significantly influencing various physiological processes such as cell proliferation, migration, differentiation, survival, stemness. The function of NF-ĸB cancer progression response to chemotherapy has gained increasing attention. This review highlights the inflammation control, biological mechanisms, therapeutic implications treatment. is instrumental altering release inflammatory factors TNF-α, IL-6, IL-1β, which are key regulation carcinogenesis. Specifically, conditions including colitis, upregulation can intensify inflammation, potentially leading development colorectal cancer. Its pivotal extends regulating tumor microenvironment, impacting components macrophages, fibroblasts, T cells, natural killer cells. influences tumorigenesis dampen anti-tumor responses. Additionally, modulates death notably by inhibiting apoptosis ferroptosis. It also dual stimulating or suppressing autophagy cancers. Beyond these functions, controlling stem fostering angiogenesis, metastatic potential through EMT induction, reducing sensitivity radiotherapy. Given its oncogenic capabilities, research focused on products small molecule compounds that suppress NF-ĸB, offering promising avenues for therapy.

Language: Английский

Citations

21
P-glycoprotein (P-gp)-driven cancer drug resistance: biological profile, non-coding RNAs, drugs and nanomodulators DOI

Yang Guo,

Milad Ashrafizadeh, Murtaza M. Tambuwala

et al.

Drug Discovery Today, Journal Year: 2024, Volume and Issue: 29(11), P. 104161 - 104161

Published: Sept. 7, 2024

Language: Английский

Citations

21
Complex roles of autophagy in cancer development, immune evasion, and drug resistance DOI

Xuegang Niu,

Qi Sheng You, Kejun Hou

et al.

Drug Resistance Updates, Journal Year: 2024, Volume and Issue: 78, P. 101170 - 101170

Published: Nov. 15, 2024

Language: Английский

Citations

16
Emerging role of exosomes in cancer therapy: progress and challenges DOI Creative Commons
Jiale Li,

Jiachong Wang,

Zigui Chen

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 13, 2025

This review highlights recent progress in exosome-based drug delivery for cancer therapy, covering exosome biogenesis, cargo selection mechanisms, and their application across multiple types. As small extracellular vesicles, exosomes exhibit high biocompatibility low immunogenicity, making them ideal vehicles capable of efficiently targeting cells, minimizing off-target damage side effects. aims to explore the potential with a focus on applications chemotherapy, gene immunomodulation. Additionally, challenges related production standardization are analyzed, highlighting importance addressing these issues clinical application. In conclusion, systems offer promising future therapies. Further research should aim enhance efficiency facilitate translation, paving way innovative treatment strategies.

Language: Английский

Citations

10
Drug Delivery System Targeting Cancer-Associated Fibroblast for Improving Immunotherapy DOI Creative Commons

Zhongsong Zhang,

Rong Wang, Long Chen

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 483 - 503

Published: Jan. 1, 2025

Abstract: Cancer-associated fibroblasts (CAFs) are a heterogeneous population of non-malignant cells that play crucial role in the tumor microenvironment, increasingly recognized as key contributors to cancer progression, metastasis, and treatment resistance. So, targeting CAFs has always been considered an important part immunotherapy. However, improve efficacy therapy is currently major challenge. Nanomaterials show their unique advantages whole process. At present, nanomaterials have achieved significant accomplishments medical applications, particularly field cancer-targeted therapy, showing enormous potential. It confirmed can not only directly target CAFs, but also interact with microenvironment (TME) immune affect tumorigenesis. As for treatment, could enhance therapeutic effect many ways. Therefore, this review, we first summarized current understanding complex interactions between TME, cells, cells. Next, discussed common modern medicine respective impacts on tumors. Finally, focus application nano drug delivery system therapy. Keywords: cancer-associated fibroblasts, delivery, nanomedicine, immunotherapy

Language: Английский

Citations

3
A Comprehensive Review on the Green Synthesis of Nanoparticles: Advancements in Biomedical and Environmental Applications DOI
Dharmalingam Kirubakaran,

Jamith Basha Abdul Wahid,

Natchimuthu Karmegam

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Language: Английский

Citations

3
Nanomaterials in cancer immunotherapy: targeting cancer-associated fibroblasts DOI Creative Commons

Zhongsong Zhang,

Long Chen

Cancer Nanotechnology, Journal Year: 2025, Volume and Issue: 16(1)

Published: Jan. 17, 2025

Emphasizing the significance of cancer-associated fibroblasts (CAFs), non-malignant yet pivotal players within tumor microenvironment (TME), this review illuminates role inflammatory subtype (iCAF) as catalysts in cancer proliferation, metastasis, and therapeutic resistance. Given their paramount importance, targeting CAFs emerges a robust strategy evolving landscape immunotherapy. Nanomaterials, distinguished by unique features malleability, hold considerable promise biomedicine, especially precision-oriented domain therapy. Their aptitude for modulating immune responses, amplifying drug efficacy through precise delivery, discerningly focusing on cells TME situates nanomaterials formidable tools to transcend boundaries set conventional treatments. This scrutinizes convoluted interplay among CAFs, cells, TME. It further showcases widely utilized management. We underscore potential nanoscale delivery systems directed at underscoring transformative power revolutionizing therapies, enhancing precision, culminating improved patient outcomes.

Language: Английский

Citations

2
For and against tumor microenvironment: Nanoparticle-based strategies for active cancer therapy DOI Creative Commons

Soroush Karimi,

Roksana Bakhshali,

Soheil Bolandi

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101626 - 101626

Published: March 1, 2025

Cancer treatment is challenged by the tumor microenvironment (TME), which promotes drug resistance and cancer cell growth. This review offers a comprehensive innovative perspective on how nanomedicine can modify TME to enhance therapy. Strategies include using nanoparticles improve oxygenation, adjust acidity, alter extracellular matrix, making treatments more effective. Additionally, immune responses activating cells reducing suppression within tumors. By integrating these approaches with existing therapies, such as chemotherapy radiotherapy, show promise in overcoming traditional barriers. The discusses changes effectiveness of itself, creating reciprocal relationship that boosts overall efficacy. We also highlight novel strategies aimed at exploiting TME, leveraging nanoparticle-based for targeted therapy through precise modulation.

Language: Английский

Citations

2
Revolutionizing Glioblastoma Treatment: A Comprehensive Overview of Modern Therapeutic Approaches DOI Open Access
Karol Sadowski, Adrianna Jażdżewska,

Jan Kozłowski

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5774 - 5774

Published: May 26, 2024

Glioblastoma is the most common malignant primary brain tumor in adult population, with an average survival of 12.1 to 14.6 months. The standard treatment, combining surgery, radiotherapy, and chemotherapy, not as efficient we would like. However, current possibilities are no longer limited therapies due rapid advancements biotechnology. New methods enable a more precise approach by targeting individual cells antigens overcome cancer. For treatment glioblastoma, these gamma knife therapy, proton beam tumor-treating fields, EGFR VEGF inhibitors, multiple RTKs PI3K pathway inhibitors. In addition, increasing understanding role immune system tumorigenesis ability identify tumor-specific helped develop immunotherapies GBM cells, including CAR-T, CAR-NK dendritic checkpoint Each described has its advantages disadvantages faces problems, such inefficient crossing blood-brain barrier, various neurological systemic side effects, escape mechanism tumor. This work aims present modern treatments glioblastoma.

Language: Английский

Citations

14