Flax fibre reinforced alginate poloxamer hydrogel: assessment of mechanical and 4D printing potential DOI Creative Commons
Charles de Kergariou, Graham J. Day, Adam W. Perriman

et al.

Soft Matter, Journal Year: 2024, Volume and Issue: 20(19), P. 4021 - 4034

Published: Jan. 1, 2024

A new 3D bioprinted biomaterial, with flax fiber-reinforced alginate hydrogel, is developed. The study assesses the impact of fibers on printing, mechanical, 4D and geometric properties composite.

Language: Английский

Electrospinning and electrospun polysaccharide-based nanofiber membranes: A review DOI

Weiyin Su,

Zeyu Chang,

E Yuyu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 263, P. 130335 - 130335

Published: Feb. 23, 2024

Language: Английский

Citations

46
Mupirocin loaded core-shell pluronic-pectin-keratin nanofibers improve human keratinocytes behavior, angiogenic activity and wound healing DOI
Marjan Mirhaj,

Jaleh Varshosaz,

Sheyda Labbaf

et al.

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 253, P. 126700 - 126700

Published: Sept. 4, 2023

Language: Английский

Citations

44
Biomimetic VEGF-loaded bilayer scaffold fabricated by 3D printing and electrospinning techniques for skin regeneration DOI Creative Commons

Amir Mohammad Danesh Pajooh,

Mohamadreza Tavakoli, Mastafa H. Al-Musawi

et al.

Materials & Design, Journal Year: 2024, Volume and Issue: 238, P. 112714 - 112714

Published: Jan. 30, 2024

Among the fabrication methods, 3D printing due to excellent accuracy, reproducibility and customizability as well electrospinning ability mimic extracellular matrix structure have received many attentions. Herein, we used combination of both mentioned techniques produce a biomimetic bilayer scaffold for skin tissue regeneration. The upper layer was made printed dextran-vascular endothelial growth factor (Dex-VEGF) stimulate angiogenesis cell migration, bottom electrospun gelatin-keratin (Gel-Kr) nanofibers induce attachment. tensile strength elastic modulus scaffolds were measured in range 0.26 – 0.33 MPa 5.8 7.2 MPa, respectively. investigations revealed that release VEGF lasted up 7 days. VEGF-loaded demonstrated best cellular behaviour. Chicken chorioallantoic membrane (CAM) assay confirmed highest angiogenic potential presence scaffold. Also, based on vivo animal studies histopathological immunohistochemical examinations, wound healing rate related within 14 obtained promising results introduce prepared perfect construct accelerate healing.

Language: Английский

Citations

33
Platelet rich fibrin and simvastatin-loaded pectin-based 3D printed-electrospun bilayer scaffold for skin tissue regeneration DOI
Mohamadreza Tavakoli, Mastafa H. Al-Musawi,

Alma Kalali

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 265, P. 130954 - 130954

Published: March 16, 2024

Language: Английский

Citations

29
Multifunctional polysaccharide/metal/polyphenol double-crosslinked hydrogel for infected wound DOI
Yun Duan,

Fuchen Jiang,

Qing Li

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 332, P. 121912 - 121912

Published: Feb. 4, 2024

Language: Английский

Citations

24
Graphene oxide-encapsulated baghdadite nanocomposite improved physical, mechanical, and biological properties of a vancomycin-loaded PMMA bone cement DOI
Mohamadreza Tavakoli, Aliakbar Najafinezhad, Marjan Mirhaj

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2024, Volume and Issue: 35(6), P. 823 - 850

Published: Feb. 1, 2024

Polymethyl methacrylate (PMMA) bone cement is commonly used in orthopedic surgeries to fill the defects or fix prostheses. These cements are usually containing amounts of a nonbioactive radiopacifying agent such as barium sulfate and zirconium dioxide, which does not have good interface compatibility with PMMA, clumps formed from these materials can scratch metal counterfaces. In this work, graphene oxide encapsulated baghdadite (GOBgh) nanoparticles were applied bioactive PMMA 2 wt.% vancomycin (VAN). The addition 20 GOBgh (GOBgh20) powder caused 33.6% increase compressive strength 70.9% elastic modulus compared Simplex® P cement, also enhanced setting properties, radiopacity, antibacterial activity, apatite formation simulated body fluid. vitro cell assessments confirmed adhesion proliferation MG-63 cells well osteogenic differentiation human adipose-derived mesenchymal stem on surface PMMA-GOBgh20 cement. chorioallantoic membrane assay revealed excellent angiogenesis activity nanocomposite samples. vivo experiments rat model demonstrated mineralization integration within four weeks. Based promising results obtained, suggested an optimal sample for use surgeries.

Language: Английский

Citations

17
MOF/MXene-loaded PVA/chitosan hydrogel with antimicrobial effect and wound healing promotion under electrical stimulation and improved mechanical properties DOI
Nan Zhang, Xiuwen Zhang,

Yueyuan Zhu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 264, P. 130625 - 130625

Published: March 6, 2024

Language: Английский

Citations

17
Highly Porous 3D Printed Scaffold Incorporated with Graphene Oxide-Merwinite and Coated with IGF1 Loaded Nanofibers for Calvarial Defect Repair DOI
Basma Talib Al-Sudani,

Saeideh Salehi,

Marwa M Kamil

et al.

Journal of Polymers and the Environment, Journal Year: 2024, Volume and Issue: 32(10), P. 5330 - 5343

Published: May 28, 2024

Language: Английский

Citations

17
A carboxymethyl cellulose/chitosan-based hydrogel harvests robust adhesive, on-demand detachment and self-healing performances for deep burn healing DOI
Mengya Li,

Haofan Qu,

Li Qin

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155552 - 155552

Published: Sept. 12, 2024

Language: Английский

Citations

16
Physicochemically Cross-linked Injectable Hydrogel: an Adhesive Skin Substitute for Burned Wound Therapy DOI
Mina Shahriari‐Khalaji, Mamoona Sattar,

Huidan Wei

et al.

ACS Applied Bio Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Burns carry a large surface area, varying in shapes and depths, an elevated risk of infection. Regardless the underlying etiology, burns pose significant medical challenges high mortality rate. Given limitations current therapies, tissue-engineering-based treatments for are inevitable. Herein, we developed natural physicochemically cross-linked adhesive injectable skin substitute (SS) comprising chitosan (Ch) silk fibroin (SF), with tannic acid (TA) through hydrogen bonding, incorporated fresh platelet-rich fibrin (FPRF). SF was also chimerically riboflavin (RF) under visible light to ensure desirable biodegradability rate nontoxicity. Double SS exhibited semibilayer (SBSS) structure smaller pores upper layer. In CaCl2-treated FPRF, activated platelets augmented vascular endothelial growth factor (VEGF) platelet-derived GF (PDGF) release. The resultant SBSS possessed optimal adhesion, hemocompatibility, antibacterial antioxidant activities (P ≤ 0.05). rat liver injury model confirmed rapid hemostatic effect SBSS. Furthermore, bottom layer promoted L929 fibroblast growth, proliferation, migration. SBSS-treated wounds showed lower inflammatory cells, earlier epithelialization, angiogenesis, faster healing. proposed could be ideal remedy burn wound therapy.

Language: Английский

Citations

3