Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 353, P. 123257 - 123257
Published: Jan. 20, 2025
Language: Английский
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(10), P. 2514 - 2514
Published: Oct. 23, 2023
Hydrogels prepared from natural polymer have attracted extensive attention in biomedical fields such as drug delivery, wound healing, and regenerative medicine due to their good biocompatibility, degradability, flexibility. This review outlines the commonly used hydrogel preparation, including cellulose, chitosan, collagen/gelatin, alginate, hyaluronic acid, starch, guar gum, agarose, dextran. The polymeric structure process/synthesis of polymers are illustrated, polymer-based hydrogels formation properties elaborated. Subsequently, applications based on tissue regeneration, other summarized. Finally, future perspectives them discussed. For polymers, novel technologies enzymatic biological methods been developed improve structural properties, development new natural-based or derivatives with high performance is still very important challenging. hydrogels, materials, like double-network hydrogel, multifunctional composite microrobots designed meet advanced requirements applications, strategies dual-cross-linking, microfluidic chip, micropatterning, 3D/4D bioprinting explored fabricate materials for applications. Overall, increasing interest strategies/methods fabrication highly desirable
Language: Английский
Citations
98
ACS Nano, Journal Year: 2023, Volume and Issue: 17(21), P. 22015 - 22034
Published: Oct. 20, 2023
Developing injectable antiswelling and high-strength bioactive hydrogels with wet tissue adhesiveness a rapid gelling process to meet the requirements for hemostasis, sutureless wound closure, scar-free repair of infected skin wounds continues have ongoing challenges. Herein, injectable, antibacterial, antioxidant hydrogel adhesives based on poly(citric acid-co-polyethylene glycol)-g-dopamine amino-terminated Pluronic F127 (APF) micelles loaded astragaloside IV (AS) are prepared. The H2O2/horseradish peroxidase (HRP) system is used cause cross-linking network through oxidative coupling between catechol groups chemical group amino group. exhibit process, high mechanical strength, an effect, good property, H2O2 release behavior, degradability. In addition, present adhesiveness, bursting pressure, excellent antibacterial activity, long-term sustained AS, biocompatibility. perform hemostasis mouse liver, rat rabbit femoral vein bleeding models achieve much better closure healing incisions than biomedical glue surgical sutures. Furthermore, dressing significantly improved MRSA-infected full thickness defect by modulating inflammation, regulating ratio collagen I/III, improving vascularization granulation formation. Thus, AS-loaded show huge potential as multifunctional dressings in vivo wounds.
Language: Английский
Citations
89
Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 332, P. 103267 - 103267
Published: Aug. 3, 2024
Language: Английский
Citations
63
Gels, Journal Year: 2024, Volume and Issue: 10(4), P. 216 - 216
Published: March 22, 2024
Hydrogels, being hydrophilic polymer networks capable of absorbing and retaining aqueous fluids, hold significant promise in biomedical applications owing to their high water content, permeability, structural similarity the extracellular matrix. Recent chemical advancements have bolstered versatility, facilitating integration molecules guiding cellular activities enabling controlled activation under time constraints. However, conventional synthetic hydrogels suffer from inherent weaknesses such as heterogeneity network imperfections, which adversely affect mechanical properties, diffusion rates, biological activity. In response these challenges, hybrid emerged, aiming enhance strength, drug release efficiency, therapeutic effectiveness. These hydrogels, featuring improved formulations, are tailored for tissue regeneration across both soft hard tissues. The scientific community has increasingly recognized versatile characteristics particularly sector. This comprehensive review delves into recent hydrogel systems, covering diverse types, modification strategies, nano/microstructures. discussion includes innovative fabrication techniques click reactions, 3D printing, photopatterning alongside elucidation mechanisms bioactive molecules. By addressing underscores envisages a promising future various domains field.
Language: Английский
Citations
41
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 509, P. 215790 - 215790
Published: March 20, 2024
Language: Английский
Citations
36
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 261, P. 129828 - 129828
Published: Jan. 29, 2024
Language: Английский
Citations
34
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 369, P. 420 - 443
Published: April 5, 2024
Language: Английский
Citations
33
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 122064 - 122064
Published: March 15, 2024
Language: Английский
Citations
32
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)
Published: May 9, 2024
Hydrogels have emerged as promising candidates for biomedical applications, especially in the field of antibacterial therapeutics, due to their unique structural properties, highly tunable physicochemical and excellent biocompatibility. The integration stimuli-responsive functions into hydrogels holds potential enhance properties therapeutic efficacy, dynamically responding different external or internal stimuli, such pH, temperature, enzymes, light. Therefore, this review describes applications hydrogel dressings responsive stimuli therapy. collaborative interaction between materials is discussed. This synergistic approach, contrast conventional materials, not only amplifies effect but also alleviates adverse side effects diminishes incidence multiple infections drug resistance. provides a comprehensive overview current challenges outlines future research directions hydrogels. It underscores imperative ongoing interdisciplinary aimed at unraveling mechanisms wound healing. understanding crucial optimizing design implementation Ultimately, aims offer scientific guidance development practical clinical application dressings.
Language: Английский
Citations
26
Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown
Published: May 11, 2024
Abstract The continuously growing utilization of wound healing materials and skin bioelectronics urges the development flexible hydrogels for personal therapy health management. Versatile conductive prepared from natural biomass are ideal candidates as one promising solutions chronic Here, study proposes a kind robust (strain: 1560.8%), adhesive, self‐healing, injectable, antibacterial (sterilization rate: 99%), near‐infrared (NIR) photothermal responsive, biocompatible, hydrogel (CPPFe@TA) composed carboxymethyl cellulose tannic acid/iron ion complex (TA@Fe 3+ ), featuring rapid self‐assembly tunable crosslinking time. TA@Fe facilitated self‐catalysis polymerization reaction, time could be controlled by adjusting Fe concentration. Under NIR irradiation, exhibited remarkable performance. In full‐thickness defect repair experiment on mice, dressing significantly enhanced healing. After 14 days, rate (95.49%) CPPFe@TA3 + treatment greatly exceeded that commercial dressings. Meanwhile, has good electrical conductivity thermo‐responsiveness, making them in physiological signal monitoring rehabilitation exercise This work therefore offers strategy developing versatile biomass‐based hydrogels, which is expected to applicable integrated regenerative bioelectronics.
Language: Английский
Citations
24