ACS Applied Bio Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 28, 2025
Breast
cancer
(BC)
is
one
of
the
most
common
cancers
among
women
and
associated
with
high
mortality.
Traditional
modalities,
including
surgery,
radiotherapy,
chemotherapy,
have
achieved
certain
advancements
but
continue
to
combat
challenges
harm
healthy
tissues,
resistance
treatment,
adverse
drug
reactions.
The
rapid
in
nanotechnology
recently
facilitated
exploration
innovative
strategies
for
breast
therapy.
Manganese-based
nanotherapeutics
attracted
great
attention
because
their
unique
characteristics
such
as
tunable
structures/morphologies,
versatility,
magnetic/optical
properties,
strong
catalytic
activities,
excellent
biodegradability,
biocompatibility.
In
this
review,
we
highlighted
different
types
Mn-based
modulate
TME,
metal-immunotherapy,
alleviating
tumor
hypoxia,
increasing
reactive
oxygen
species
production,
emphasized
its
role
magnetic
resonance
imaging
(MRI)-guided
therapy,
photoacoustic
imaging,
theranostic-based
therapy
along
a
therapeutic
carrier,
all
which
were
discussed
context
cancer.
Hopefully,
present
review
will
provide
insights
into
current
landscape
future
directions
multifunctional
applications
field
treatment.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(20), P. 12830 - 12844
Published: May 6, 2024
The
immunosuppressive
microenvironment
of
cervical
cancer
significantly
hampers
the
effectiveness
immunotherapy.
Herein,
PEGylated
manganese-doped
calcium
sulfide
nanoparticles
(MCSP)
were
developed
to
effectively
enhance
antitumor
immune
response
through
gas-amplified
metalloimmunotherapy
with
dual
activation
pyroptosis
and
STING
pathway.
bioactive
MCSP
exhibited
ability
rapidly
release
Ca2+,
Mn2+,
H2S
in
tumor
microenvironment.
disrupted
buffer
system
cells
by
interfering
oxidative
phosphorylation
pathway,
leading
overload-triggered
pyroptosis.
On
other
hand,
H2S-mediated
mitochondrial
dysfunction
further
promoted
DNA
(mtDNA),
enhancing
effect
Mn2+
on
cGAS-STING
signaling
axis
thereby
activating
immunosuppressed
dendritic
cells.
released
acted
as
an
important
synergist
between
Ca2+
modulating
mechanisms
bridge
innate
adaptive
responses.
combination
NPs
PD-1
immunotherapy
achieved
synergistic
effects
inhibited
growth.
This
study
reveals
potential
collaboration
gas
therapy
provides
idea
for
design
nanoimmunomodulators
rational
regulation
Small,
Journal Year:
2024,
Volume and Issue:
20(25)
Published: Jan. 14, 2024
Abstract
Ferroptosis
is
a
new
form
of
regulated
cell
death
featuring
iron‐dependent
lipid
peroxides
accumulation
to
kill
tumor
cells.
A
growing
body
evidence
has
shown
the
potential
ferroptosis‐based
cancer
therapy
in
eradicating
refractory
malignancies
that
are
resistant
apoptosis‐based
conventional
therapies.
In
recent
years,
studies
have
reported
number
ferroptosis
inducers
can
increase
vulnerability
cells
by
regulating
ferroptosis‐related
signaling
pathways.
Encouraged
rapid
development
ferroptosis‐driven
therapies,
interdisciplinary
fields
combine
ferroptosis,
pharmaceutical
chemistry,
and
nanotechnology
focused.
First,
prerequisites
metabolic
pathways
for
briefly
introduced.
Then,
detail
emerging
designed
boost
ferroptosis‐induced
therapy,
including
metal
complexes,
metal‐based
nanoparticles,
metal‐free
nanoparticles
summarized.
Subsequently,
application
synergistic
strategies
with
apoptosis
other
emphasis
on
use
both
cuproptosis
induce
redox
dysregulation
intracellular
bimetallic
copper/iron
metabolism
disorders
during
treatment
discussed.
Finally,
challenges
associated
clinical
translation
future
directions
potentiating
therapies
highlighted.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(26)
Published: May 5, 2024
Abstract
Surgical
resection
remains
the
mainstream
treatment
for
malignant
melanoma.
However,
challenges
in
wound
healing
and
residual
tumor
metastasis
pose
significant
hurdles,
resulting
high
recurrence
rates
patients.
Herein,
a
bioactive
injectable
hydrogel
(BG‐Mn
gel
)
formed
by
crosslinking
sodium
alginate
(SA)
with
manganese‐doped
glass
(BG‐Mn)
is
developed
as
versatile
platform
anti‐tumor
immunotherapy
postoperative
The
incorporation
of
Mn
2+
within
(BG)
can
activate
cGAS‐STING
immune
pathway
to
elicit
robust
response
cancer
immunotherapy.
Furthermore,
doping
BG
endows
system
excellent
photothermal
properties,
hence
facilitating
STING
activation
reversing
immune‐suppressive
microenvironment.
exhibits
favorable
angiogenic
capacity
tissue
regenerative
potential,
promotes
cell
migration
vitro.
When
combining
BG‐Mn
anti‐PD‐1
antibody
(α‐PD‐1)
melanoma,
it
shows
enhanced
long‐term
memory
response.
Remarkably,
upregulate
expression
genes
related
blood
vessel
formation
promote
skin
regeneration
when
treating
full‐thickness
wounds.
Overall,
Gel
serves
an
effective
adjuvant
therapy
regulate
Journal of Experimental & Clinical Cancer Research,
Journal Year:
2024,
Volume and Issue:
43(1)
Published: Nov. 30, 2024
Abstract
Ferroptosis
is
a
type
of
regulated
cell
death
characterized
by
its
non-apoptotic,
iron-dependent
and
oxidative
nature.
Since
discovery
in
2012,
extensive
research
has
demonstrated
pivotal
roles
tumorigenesis,
metastasis
cancer
therapy.
The
tumor
microenvironment
(TME)
complex
ecosystem
comprising
cells,
non-cancer
extracellular
matrix,
metabolites
cytokines.
Recent
studies
have
underscored
new
paradigm
which
cells
the
TME,
such
as
immune
stromal
also
play
significant
regulating
progression
therapeutic
resistance
typically
through
complicated
crosstalk
with
cells.
Notably,
this
TME
were
partially
mediated
ferrotopsis-related
mechanisms.
This
review
provides
comprehensive
systematic
summary
current
findings
concerning
ferroptosis
how
ferroptosis-mediated
reprogramming
impacts
progression.
Additionally,
outlines
various
ferroptosis-related
strategies
aimed
at
targeting
TME.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 6, 2025
Immunogenic
cell
death
(ICD)-mediated
immunization
strategies
have
great
potential
against
breast
cancer.
However,
traditional
neglect
the
increase
in
immunosuppressive
metabolite,
adenosine
(ADO),
during
ICD,
leading
to
insufficient
therapeutic
outcomes.
In
this
study,
it
is
found
that
A2A
receptor
(A2AR)
significantly
expressed
cancer
and
positively
associated
with
regulatory
T
(Treg)
cells.
Herein,
a
strategy
combining
Fe/Mo-based
lipid
peroxidation
(LPO)
nanoamplifiers
A2AR
blockade
reported
maximize
ICD-mediated
anti-tumor
immunity.
This
LPO
nanoamplifier
causes
explosion
by
Fe
(II)-mediated
Fenton
reaction
Mo(V)-mediated
Russell
mechanism.
Subsequently,
elicits
ICD
magnification
of
tumor
cells
inducing
multiple
regulated
patterns
ferroptosis,
apoptosis,
necroptosis.
Additionally,
antagonist
(SCH58261),
an
immunometabolic
checkpoint
blocker,
relieve
ADO-related
immunosuppression,
amplify
immunological
effects,
elicit
immune
memory
responses.
robust
immunity
observed
primary,
distant,
pulmonary
metastatic,
recurrent
tumors.
study
provides
novel
for
optimizing
immunotherapy
highlights
benefits
enhance
immunotherapy.
Advanced Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 7, 2025
Abstract
The
cGAS‐STING
pathway
is
pivotal
in
initiating
antitumor
immunity.
However,
tumor
metabolism,
particularly
glycolysis,
negatively
regulates
the
activation
of
pathway.
Herein,
Mn
galvanic
cells
(MnG)
are
prepared
via
liquid‐phase
exfoliation
and
situ
replacement
to
modulate
thereby
enhancing
for
bidirectional
synergistic
H
2
‐immunotherapy.
obtained
MnG
can
be
etched
by
water,
enabling
efficient
sustained
generation
gas
2+
.
not
only
activated
amplified
through
release
but
also
regulated
glucose
metabolism
inhibit
expression
three
prime
repair
exonuclease
(TREX2),
synergistically
injection
into
tumors
resulted
a
robust
immune
response,
providing
favorable
support
therapy.
Consequently,
combination
with
checkpoint
blockade
therapy
significant
suppression
both
primary
distant
tumors.
Furthermore,
MnG‐lipiodol
dispersion
exhibited
remarkable
efficacy
transarterial
embolization
(TAE)‐gas‐immunotherapy
rabbit
orthotopic
liver
model.
present
study
underscores
significance
employing
metal
cell
strategy
enhanced
immunotherapy,
offering
novel
approach
rational
design
bioactive
materials
augment
immunotherapeutic
effectiveness.
