Janus Nanofiber Membranes with Photothermal‐Enhanced Biofluid Drainage and Sterilization for Diabetic Wounds

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(24)

Published: Feb. 16, 2024

Abstract Diabetic wounds are difficult to heal, and the key wound healing is exudate management effective disinfection. Inspired by asymmetric wettability of Janus‐structured lotus leaves, herein study has presented design a biomimetic Janus membrane that integrates unidirectional biofluid drainage photothermal‐enhanced evaporation/sterilization capabilities for accelerating diabetic healing. This prepared electrospinning polyacrylonitrile (PAN) nanofiber containing polydopamine (PDA) on surface polypropylene (PP) nonwoven membrane. Such PP/PAN x%PDA enables antigravity “pumping” water from hydrophobic PP layer hydrophilic PAN within 22 s through contact points interface. The incorporation 30 wt% PDA in imparts high photoabsorption photothermal responsiveness, facilitating continuous volatilization exudate, achieving twice displacement water, causing irreversible damage bacteria. As result, it effectively alleviates inflammation cellular fibrosis while promoting collagen deposition due its structure antibacterial properties. Impressively, such achieves an impressive closure rate 96.7% wounds, better than (59.8%) conventional bandages. Therefore, this offers promising alternative chronic wounds.

Language: Английский

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ROS-scavenging materials for skin wound healing: advancements and applications

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Dec. 12, 2023

The intricate healing process of skin wounds includes a variety cellular and molecular events. Wound heavily relies on reactive oxygen species (ROS), which are essential for controlling various processes, including inflammation, cell growth, angiogenesis, granulation, the formation extracellular matrix. Nevertheless, an overabundance (ROS) caused by extended oxidative pressure may result in postponement or failure wound healing. It is crucial to comprehend function create biomaterials that efficiently eliminate ROS enhance wounds. In this study, thorough examination presented role healing, along with exploration existing knowledge regarding employed elimination. addition, article covers different techniques substances used management wound. future prospects clinical applications enhanced also emphasized, highlighting potential scavenge active promote repair. This seeks understanding complex processes application ROS-scavenging materials. Its objective novel strategies effective treatment

Language: Английский

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A Double Network Composite Hydrogel with Self-Regulating Cu²⁺/Luteolin Release and Mechanical Modulation for Enhanced Wound Healing

ACS Nano, Journal Year: 2024, Volume and Issue: 18(26), P. 17251 - 17266

Published: June 22, 2024

Designing adaptive and smart hydrogel wound dressings to meet specific needs across different stages of healing is crucial. Here, we present a composite hydrogel, GSC/PBE@Lut, that offers self-regulating release cupric ions luteolin modulates mechanical properties promote chronic healing. The double network GSC, fabricated through photo-cross-linking gelatin methacrylate, followed by Cu2+-alginate coordination cross-linking. On one hand, GSC allows for rapid Cu2+ eliminate bacteria in the acidic pH environment during inflammation reduces hydrogel's strength minimize tissue trauma early dressing changes. other enables slow proliferation stage, promoting angiogenesis biocompatibility. Furthermore, inclusion pH- reactive oxygen species (ROS)-responsive nanoparticles (PBE@Lut) matrix controlled luteolin, offering antioxidant anti-inflammatory effects macrophage polarization. In murine model Staphylococcus aureus infected wounds, GSC/PBE@Lut demonstrates exceptional therapeutic benefits antibacterial, anti-inflammatory, angiogenic, regeneration. Overall, our results suggest hydrogels with bioactive agent modulation promising solution treating wounds.

Language: Английский

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MOFs and MOF‐Based Composites as Next‐Generation Materials for Wound Healing and Dressings

Small, Journal Year: 2024, Volume and Issue: 20(30)

Published: March 7, 2024

Abstract In recent years, there has been growing interest in developing innovative materials and therapeutic strategies to enhance wound healing outcomes, especially for chronic wounds antimicrobial resistance. Metal–organic frameworks (MOFs) represent a promising class of next‐generation dressings. Their high surface area, pore structures, stimuli‐responsiveness, antibacterial properties, biocompatibility, potential combination therapies make them suitable complex care challenges. MOF‐based composites promote cell proliferation, angiogenesis, matrix synthesis, acting as carriers bioactive molecules promoting tissue regeneration. They also have stimuli‐responsivity, enabling photothermal skin cancer infections. Herein, critical analysis the current state research on MOFs dressings is provided, offering valuable insights into applications, challenges, future directions this field. This literature review targeted multifunctionality nature wound‐disease therapy from different aspects discussed most advancements made context, reader will find how contributed field yield more effective, functional, they lead next generation biomaterials

Language: Английский

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Developing fibrin-based biomaterials/scaffolds in tissue engineering

Bioactive Materials, Journal Year: 2024, Volume and Issue: 40, P. 597 - 623

Published: Aug. 15, 2024

Tissue engineering technology has advanced rapidly in recent years, offering opportunities to construct biologically active tissues or organ substitutes repair even enhance the functions of diseased and organs. Tissue-engineered scaffolds rebuild extracellular microenvironment by mimicking matrix. Fibrin-based possess numerous advantages, including hemostasis, high biocompatibility, good degradability. Fibrin provide an initial matrix that facilitates cell migration, differentiation, proliferation, adhesion, also play a critical role cell-matrix interactions. are now widely recognized as key component tissue engineering, where they can facilitate defect repair. This review introduces properties fibrin, its composition, structure, biology. In addition, modification cross-linking modes fibrin discussed, along with various forms commonly used engineering. We describe biofunctionalization fibrin. provides detailed overview use applications skin, bone, nervous tissues, novel insights into future research directions for clinical treatment.

Language: Английский

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Copper-based nanomaterials for the treatment of bacteria-infected wounds: material classification, strategies and mechanisms

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216205 - 216205

Published: Sept. 11, 2024

Language: Английский

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A Multifunctional Herb‐Derived Glycopeptide Hydrogel for Chronic Wound Healing

Small, Journal Year: 2024, Volume and Issue: unknown

Published: April 30, 2024

Chronic wounds constitute an increasingly prevalent global healthcare issue, characterized by recurring bacterial infections, pronounced oxidative stress, compromised functionality of immune cells, unrelenting inflammatory reactions, and deficits in angiogenesis. In response to these multifaceted challenges, the study introduced a stimulus-responsive glycopeptide hydrogel constructed oxidized Bletilla striata polysaccharide (OBSP), gallic acid-grafted ε-Polylysine (PLY-GA), paeoniflorin-loaded micelles (MIC@Pae), called OBPG&MP. The emulates structure glycoprotein fibers extracellular matrix (ECM), exhibiting exceptional injectability, self-healing, biocompatibility. It adapts responsively microenvironment chronic wounds, sequentially releasing therapeutic agents eradicate infection, neutralize reactive oxygen species (ROS), modulate macrophage polarization, suppress inflammation, encourage vascular regeneration ECM remodeling, playing critical role across inflammatory, proliferative, remodeling phases wound healing. Both vitro vivo studies confirmed efficacy OBPG&MP regulating enhancing skin tissue. This research supports vast potential for herb-derived multifunctional hydrogels tissue engineering regenerative medicine.

Language: Английский

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Review on application of herbal extracts in biomacromolecules-based nanofibers as wound dressings and skin tissue engineering

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 133666 - 133666

Published: July 5, 2024

Language: Английский

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Copper incorporated biomaterial-based technologies for multifunctional wound repair

Theranostics, Journal Year: 2023, Volume and Issue: 14(2), P. 547 - 570

Published: Dec. 5, 2023

The treatment of wounds is a worldwide challenge, and wound infection can affect the effectiveness further increase disease burden. Copper an essential trace element that has been shown to have broad-spectrum antibacterial effects be involved in inflammation, proliferation, remodeling stages healing. Compared treatments such as bioactive factors skin grafts, copper advantage being low-cost easily available, received lot attention Recently, biomaterials made by incorporating into glasses, polymeric scaffolds hydrogels used promote healing release ions. In addition, copper-incorporated with catalytic, photothermal, photosensitive properties also accelerate through microenvironment regulation. This review summarizes mechanisms copper- incorporated their roles healing, discusses current challenges. A comprehensive understanding role will help facilitate new preclinical clinical studies, thus leading development novel therapeutic tools.

Language: Английский

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A multifunctional injectable, self-healing, and adhesive hydrogel-based wound dressing stimulated diabetic wound healing with combined reactive oxygen species scavenging, hyperglycemia reducing, and bacteria-killing abilities

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 27, 2024

The proficient handling of diabetic wounds, a rising issue coinciding with the global escalation diabetes cases, poses significant clinical difficulties. A range biofunctional dressings have been engineered and produced to expedite healing process wounds. This study proposes multifunctional hydrogel dressing for wound healing, which is composed Polyvinyl Alcohol (PVA) N1-(4-boronobenzyl)-N3-(4-boronophenyl)-N1, N1, N3, N3-teramethylpropane-1, 3-diaminium (TSPBA), dual-drug loaded Gelatin methacryloyl (GM) microgel. GM microgel sodium fusidate (SF) nanoliposomes (LP) that contain metformin hydrochloride (MH). Notably, adhesive self-healing properties enhance their therapeutic potential ease application. In vitro assessments indicate SF-infused can eliminate more than 98% bacteria within 24 h maintain sustained release over 15 days. Additionally, MH incorporated has demonstrated effective glucose level regulation duration exceeding demonstrates ability neutralize ROS throughout entire process, predominantly by electron donation sequestration. dressing, integrated biological functions efficient bactericidal activity against both MSSA MRSA strains, blood modulation, control active oxygen levels, successfully promoted wounds in rats 14 exhibited effectiveness facilitating highlighting its considerable promise translation.

Language: Английский

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