Beyond cancer: The potential application of CD47-based therapy in non-cancer diseases DOI Creative Commons

Wei-Qing Deng,

Zi-Han Ye,

Zhenghai Tang

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 15(2), P. 757 - 791

Published: Nov. 28, 2024

CD47 is an immune checkpoint widely regarded as a 'don't eat me' signal. CD47-based anti-cancer therapy has received considerable attention, with significant number of clinical trials conducted. While therapies based on remain focal point interest among researchers, it noteworthy that increasing studies have found ameliorated the pathological status non-cancer diseases. This review aims to provide overview recent progress in comprehending role diseases, including diseases circulatory system, nervous digestive and so on. Furthermore, we sought delineate promising mechanisms treating Our findings suggest agents may exert their effect by regulating phagocytosis, T cells, dendritic neutrophils, secretion cytokines chemokines. Additionally, put forward orientation further research bring light potential its binding partners target

Language: Английский

Advanced Applications of Nanomaterials in Atherosclerosis Diagnosis and Treatment: Challenges and Future Prospects DOI

Junran Tong,

Zhiwen Wang, Jiahui Zhang

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(43), P. 58072 - 58099

Published: Oct. 21, 2024

Atherosclerosis-induced coronary artery disease is a major cause of cardiovascular mortality. Clinically, conservative treatment strategies for atherosclerosis still focus on lifestyle interventions and the use lipid-lowering anticoagulant medications. Despite achieving some therapeutic effects, these approaches are limited by low bioavailability, long intervention periods, significant side effects. With advancement nanotechnology, nanomaterials have demonstrated extraordinary potential in biomedical field. Their excellent biocompatibility, surface modifiability, high targeting capability not only enable efficient diagnosis plaque progression but also allow precise drug delivery within atherosclerotic plaques, significantly enhancing bioavailability reducing systemic Here, we systematically review current research progress field to summarize types their applications both atherosclerosis. Notably, context therapy, provide comprehensive overview nanomaterial based targeted systems different cell plaques. Additionally, address persistent challenge clinical translation summarizing issues providing directions innovation improvement design. Overall, believe that this summarizes challenges thereby offering insights references development materials

Language: Английский

Citations

4
Biomimetic metal-phenolic nanocarrier for co-delivery of multiple phytomedical bioactive components for anti-atherosclerotic therapy DOI
Yao Chen,

Dongmei Pan,

Qingshan Zhu

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125228 - 125228

Published: Jan. 1, 2025

Language: Английский

Citations

0
Macrophage membrane enveloped on double-locked nanoplatform with right-side-out orientation to improving precise theranostic for atherosclerosis DOI
Jie Liu,

Zhigui He,

Xian Qin

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 800 - 817

Published: Feb. 18, 2025

Language: Английский

Citations

0
How Advanced Is Nanomedicine for Atherosclerosis? DOI Creative Commons

Xiang Gu,

Lixin Du,

Ran Lin

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 3445 - 3470

Published: March 1, 2025

Advances in nanotechnology have opened new avenues for precision therapy, personalized medicine, and multifunctional theranostics atherosclerosis (AS). This review provides a comprehensive overview of the role nanoparticles (NPs) medicine AS, discussing their applications, challenges, future prospects. The first analyzes current treatment landscape AS outlines potential biological targets therapy. Various nanocarriers, including organic, inorganic, hybrid systems, are evaluated therapeutic potential, with focus on targeted drug delivery, anti-inflammatory vascular repair, plaque stabilization, lipid clearance. Additionally, explores NP preparation methods, emphasizing strategies to enhance loading, stability, controlled release. Finally, translational challenges NP-based therapies, biocompatibility, large-scale production, regulatory hurdles, clinical implementation, critically analyzed. Future directions highlight importance interdisciplinary collaboration technological innovation advancing nanoparticle-based AS.

Language: Английский

Citations

0
Red Blood Cell Membrane Spontaneously Coated Nanoprodrug Based on Phosphatidylserine for Antiatherosclerosis Applications DOI

Yu Cao,

Zhiqiang Han, Li Zhu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(35), P. 46578 - 46589

Published: Aug. 22, 2024

Atherosclerosis (AS) is characterized by the accumulation of lipids within walls coronary arteries, leading to arterial narrowing and hardening. It serves as primary etiology pathological basis for cardiovascular diseases affecting heart brain. However, conventional pharmacotherapy constrained inadequate drug delivery pronounced toxic side effects. Moreover, inefficacy nanomedicine systems in controlling disease progression may be attributed nonspecific clearance mononuclear phagocyte system. Thus, a biomimetic platform spontaneously enveloped red blood cell membrane exploited anti-atherosclerosis applications, offering favorable biocompatibility. The CLIKKPF polypeptide introduced develop encapsulated nanotherapeutics only through simple coincubation. Given functional modifications, RBC@P-LVTNPs beneficial facilitate target atherosclerotic lesion, responding precisely ROS accumulation, thereby accelerating on-demand release. Both vivo vitro results also confirm significant therapeutic efficacy biocompatibility system, thus providing promising candidate against AS.

Language: Английский

Citations

2
Chondroitin sulfate functionalized nanozymes inhibit the inflammation feedback loop for enhanced atherosclerosis therapy by regulating intercellular crosstalk DOI
Chenglong Wang, Yufeng He, Jun Tang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136918 - 136918

Published: Oct. 1, 2024

Language: Английский

Citations

2
Macrophage Membrane Spontaneously Encapsulated Cyclodextrin-Based Nanomedicines for Improving Lipid Metabolism and Inflammation in Atherosclerosis DOI

Nianlian Mou,

Xinmei Duan,

Kai Qu

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(37), P. 49660 - 49672

Published: Sept. 6, 2024

Atherosclerosis is a persistent inflammatory condition of the blood vessels associated with abnormalities in lipid metabolism. Development biomimetic nanoplatforms provides an effective strategy. Herein, inspired by peptide CLIKKPF spontaneously coupling to phosphatidylserine (PS) on inner leaflet cell membranes specifically, MM@NPs were constructed macrophage membrane spontaneous encapsulation cyclodextrin-based nanoparticles modified and loaded hydrophobic compound resveratrol. could be specifically phagocytized activated endothelium overexpressed VCAM-1 for enhancing target delivery into pathological lesion. Additionally, ApoE

Language: Английский

Citations

1
Emerging nanoprobes for the features visualization of vulnerable atherosclerotic plaques DOI Creative Commons
Xin Wang, Dan Mu, Jing Liang

et al.

Smart Medicine, Journal Year: 2024, Volume and Issue: 3(4)

Published: Dec. 1, 2024

Abstract Atherosclerosis (AS) is a major cause of cardiovascular disease. In particular, the unpredictable rupture vulnerable atherosclerotic plaques (VASPs) can serious events such as myocardial infarction, stroke, and even sudden death. Therefore, early evaluation vulnerability great importance. However, clinical imaging techniques are only marginally useful in presence severe anatomical structural changes, making it difficult to evaluate plaque at an stage. With development molecular nanotechnology, specific nanoprobes constructed for pathological features VASPs have attracted much attention their ability visualize noninvasively cellular levels. Here, we outline VASPs, analyze superiority limitations current techniques, introduce rational design principles nanoprobes, systematically summarize application addition, discussed prospects urgent challenges this field, believe will provide new ideas accurate diagnosis diseases.

Language: Английский

Citations

1
Shedding new light on atherosclerosis therapeutics: Nanomedicines targeting atherosclerotic immune microenvironment DOI Creative Commons
Zhiyue Wang, Jie Sheng,

Guangming Lu

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(3), P. 100043 - 100043

Published: Nov. 14, 2024

Language: Английский

Citations

0
Beyond cancer: The potential application of CD47-based therapy in non-cancer diseases DOI Creative Commons

Wei-Qing Deng,

Zi-Han Ye,

Zhenghai Tang

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 15(2), P. 757 - 791

Published: Nov. 28, 2024

CD47 is an immune checkpoint widely regarded as a 'don't eat me' signal. CD47-based anti-cancer therapy has received considerable attention, with significant number of clinical trials conducted. While therapies based on remain focal point interest among researchers, it noteworthy that increasing studies have found ameliorated the pathological status non-cancer diseases. This review aims to provide overview recent progress in comprehending role diseases, including diseases circulatory system, nervous digestive and so on. Furthermore, we sought delineate promising mechanisms treating Our findings suggest agents may exert their effect by regulating phagocytosis, T cells, dendritic neutrophils, secretion cytokines chemokines. Additionally, put forward orientation further research bring light potential its binding partners target

Language: Английский

Citations

0