Gels,
Journal Year:
2025,
Volume and Issue:
11(3), P. 191 - 191
Published: March 8, 2025
Three-dimensional
bioprinting
is
a
new
advance
in
tissue
engineering
and
regenerative
medicine.
Bioprinting
allows
manufacturing
three-dimensional
(3D)
structures
that
mimic
tissues
or
organs.
The
bioinks
used
are
mainly
made
of
natural
synthetic
polymers
must
be
biocompatible,
printable,
biodegradable.
These
may
incorporate
progenitor
cells,
favoring
graft
implantation
regeneration
injured
tissues.
However,
the
natures
biomaterials,
processes,
lack
vascularization,
immune
responses
factors
limit
viability
functionality
implanted
cells
damaged
limitations
can
addressed
by
incorporating
extracellular
vesicles
(EV)
into
bioinks.
Indeed,
EV
from
have
capacities,
being
similar
to
those
their
source
cells.
Therefore,
combinations
with
biomaterials
cell-free
therapies.
Likewise,
they
complement
manufacture
increasing
viability,
differentiation,
ability
incorporated
Thus,
main
objective
this
review
show
how
use
3D
technology
for
application
medicine
these
nanovesicles
hydrogels
as
To
end,
latest
advances
derived
vitro
vivo
studies
been
described.
Together,
high
therapeutic
potential
strategy
Luminescence,
Journal Year:
2025,
Volume and Issue:
40(3)
Published: March 1, 2025
ABSTRACT
In
recent
years,
with
the
rapid
development
of
flexible
electronics,
implantable
electronic
devices
have
received
increasing
attention,
and
they
provide
new
solutions
for
medical
diagnosis
treatment.
To
ensure
long‐term
stable
operation
in
internal
environment,
materials
conductivity,
flexibility,
biocompatibility,
other
properties
are
high
demand.
Hydrogels
polymers
three‐dimensional
network
structures
that
not
only
physical
chemical
similar
to
those
biological
tissues
but
can
be
also
modulated
by
introducing
functional
groups
regulate
adhesion,
self‐healing,
functions.
Therefore,
hydrogel‐based
bioelectronic
considered
a
candidate
direction
future
biomedical
field.
Here,
this
paper
reviews
research
progress
molecular
design
performance
modulation
functionalized
hydrogels
based
on
four
key
hydrogels:
toughness.
The
latest
use
device
applications
is
summarized
below.
Finally,
discussions
given
challenges
opportunities
devices.
Materials Today Bio,
Journal Year:
2025,
Volume and Issue:
32, P. 101769 - 101769
Published: April 12, 2025
Wound
healing
in
patients
with
diabetes
is
challenging
because
of
chronic
inflammation,
inadequate
vascularization,
and
susceptibility
to
infection.
Current
wound
dressings
often
target
specific
stages
lack
comprehensive
therapeutic
approaches.
This
study
introduces
a
novel
approach
using
photodetachable
sponge
scaffold
incorporating
carbon
nanotubes
(CNTs),
known
for
their
high
photothermal
conversion
efficiency,
electrical
conductivity,
water
absorption
properties.
The
incorporated
pyrrolidonecarboxylic
acid
zinc
(PC1Z2),
compound
anti-inflammatory
moisturizing
properties,
which
was
cross-linked
within
network
CNTs
decellularized
dermal
matrix.
resulting
shape-memory
actively
interfaces
endogenous
electric
fields,
facilitating
signal
transmission
skin
cells
accelerating
tissue
repair.
Upon
exposure
near-infrared
(NIR)
light,
the
PC1Z2
enhanced
antibacterial
efficacy
(98
%)
through
conversion,
promoting
metabolism
at
site.
Notably,
absorbed
exudates
gradually
released
Zn2+,
effectively
reducing
inflammation
mice.
In
diabetic
rat
model,
exudates,
reduced
accelerated
granulation
formation,
angiogenesis,
re-epithelialization.
innovative
dressing
shows
promise
enhancing
wounds.
Frontiers in Neuroscience,
Journal Year:
2025,
Volume and Issue:
19
Published: May 12, 2025
Functional
recovery
following
spinal
cord
injury
(SCI)
presents
significant
challenges
and
imposes
a
substantial
burden
on
society.
Current
research
primarily
focuses
minimizing
damage
promoting
regeneration
to
enhance
functional
after
SCI.
Following
SCI,
secondary
injuries
such
as
mitochondrial
dysfunction,
vascular
rupture,
inflammatory
responses,
glial
scarring
occur
in
the
lesion
area,
forming
pathological
microenvironment.
These
factors
expand
extent
of
damage,
exacerbate
severity,
severely
impede
axonal
Modulating
microenvironment
through
various
interventions
may
facilitate
promote
This
article
reviews
influence
advancements
axon
concerning
response,
scar
formation
Additionally,
it
integrates
insights
from
bioengineering
improve
microenvironment,
summarizing
progress
research.
The
review
concludes
with
novel
strategies
for
enhancing
regeneration,
offering
fresh
perspectives
future
investigations.
Journal of Biomedical Materials Research Part A,
Journal Year:
2024,
Volume and Issue:
113(1)
Published: Dec. 24, 2024
With
no
effective
treatments
for
functional
recovery
after
injury,
spinal
cord
injury
(SCI)
remains
one
of
the
unresolved
healthcare
challenges.
Human
induced
pluripotent
stem
cell
(hiPSC)
transplantation
is
a
versatile
patient-specific
regenerative
approach
SCI.
Injectable
electroconductive
hydrogel
(ECH)
can
further
enhance
efficacy
through
minimally
invasive
manner
as
well
recapitulate
native
bioelectrical
microenvironment
neural
tissue.
Given
these
considerations,
we
report
novel
ECH
prepared
self-assembly
facilitated
in
situ
gelation
natural
silk
fibroin
(SF)
derived
from
mulberry
Bombyx
mori
and
electrically
conductive
PEDOT:PSS.
PEDOT:PSS
was
pre-stabilized
to
prevent
potential
delamination
its
hydrophilic
PSS
chain
under
aqueous
environment
using
3%
(v/v)
(3-glycidyloxypropyl)trimethoxysilane
(GoPS)
(w/v)
poly(ethylene
glycol)diglycidyl
ether
(PeGDE).
The
resultant
formulations
are
easily
injectable
with
standard
hand
force
flow
point
below
100
Pa
good
shear-thinning
properties.
unmodified
GoPS-modified
PEDOT:PSS,
that
is,
SF/PEDOT
SF/PEDOTGoP
maintain
comparable
elastic
modulus
(~10-60
kPa)
physiological
condition,
indicating
their
flexibility.
ECHs
also
display
improved
structural
recoverability
(~70%-90%)
compared
versions
(~30%-80%),
indicated
by
three
interval
time
thixotropy
(3ITT)
test.
Additionally,
possess
electrical
conductivity
range
~0.2-1.2
S/m
(1-10
S/m),
ability
mimic
environment.
Approximately
80%
or
more
survival
observed
when
hiPSC-derived
cortical
neurons
astrocytes
were
encapsulated
within
ECHs.
These
support
maturation
embedded
7
days,
fostering
development
complex,
interconnected
network
long
axonal
processes
promoting
synaptogenesis.
results
underline
therapy
regeneration.
Gels,
Journal Year:
2024,
Volume and Issue:
10(10), P. 614 - 614
Published: Sept. 25, 2024
Interfaces
between
implantable
bioelectrodes
and
tissues
provide
critical
insights
into
the
biological
pathological
conditions
of
targeted
organs,
aiding
diagnosis
treatment.
While
conventional
bioelectronics,
made
from
rigid
materials
like
metals
silicon,
have
been
essential
for
recording
signals
delivering
electric
stimulation,
they
face
limitations
due
to
mechanical
mismatch
devices
soft
tissues.
Recently,
focus
has
shifted
toward
conductive
materials,
such
as
hydrogels
hydrogel
nanocomposites,
known
their
tissue-like
softness,
biocompatibility,
potential
functionalization.
This
review
introduces
these
provides
an
overview
recent
advances
in
nanocomposites
electronics.
It
covers
material
strategies
hydrogels,
including
both
intrinsically
explores
key
functionalization
techniques
biodegradation,
bioadhesiveness,
injectability,
self-healing.
Practical
applications
electronics
are
also
highlighted,
showcasing
effectiveness
real-world
scenarios.
Finally,
we
discuss
emerging
technologies
future
needs
chronically
offering
evolving
landscape
this
field.
