Small,
Journal Year:
2024,
Volume and Issue:
21(6)
Published: Dec. 29, 2024
Abstract
Resin‐based
materials
(RBMs)
are
widely
applied
in
dentistry
because
they
withstand
the
recurrent
multi‐dimensional
force
striking
and
hydrolysis
of
teeth.
Sub‐nanoscale
can
enhance
mechanical
strength
bioactivity
RBMs,
but
effects
still
limited
mechanisms
to
remain
unclear.
Here,
a
TiO
2
‐based
sub‐nanocomposite
modified
with
caffeic
acid
(CA)
robustness,
structural
stability,
RBMs
is
reported.
This
promote
proliferation,
adhesion,
odontogenic
differentiation
human
dental
pulp
stem
cells
(hDPSCs)
through
specifically
up‐regulating
expression
genes
related
cell‐matrix
integrin‐mediated
signaling
pathways,
collagen
fibril
organization.
These
lead
better
capacity
for
RBMs.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 11, 2024
Abstract
The
main
features
of
early
caries
are
the
massive
colonization
cariogenic
bacteria
and
demineralization
tooth
enamel
by
acids
that
they
produce.
Owing
to
lack
effective
treatments,
development
anticaries
therapeutics
with
both
antimicrobial
remineralizing
properties
is
urgently
required.
Black
phosphorus
nanosheets
(BPNs)
ideal
for
treatment
because
can
mediate
photothermal
antibacterial
activity
subsequently
promote
remineralization
generating
PO
4
3−
.
However,
dynamic
wet
environment
oral
cavity
prevents
long‐term
adhesion
BPNs
surface.
In
this
study,
using
catechol‐modified
chitosan
PLGA‐PEG‐PLGA
as
raw
materials,
a
mussel‐inspired
versatile
hydrogel,
BP@CP5,
presented
be
used
physically
load
BPNs.
BP@CP5
has
exceptional
injectability
firmly
adhere
surfaces
up
24
h.
Upon
irradiation,
quickly
eliminate
≈99%
Streptococcus
mutans
sanguinis
;
furthermore,
generated
via
degradation
also
promotes
rapid
slabs.
Importantly,
vivo
rodent
modeling
results
further
confirm
excellent
caries‐prevention
BP@CP5.
This
study
demonstrates
promising
material
management.
Medical Review,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 22, 2024
Dental
caries,
driven
by
plaque
biofilm,
poses
a
major
oral
health
challenge
due
to
imbalance
in
mineralization
and
demineralization.
The
primary
objective
caries
management
is
maintain
biofilm
homeostasis
while
facilitating
the
repair
regeneration
of
dental
hard
tissues,
thus
restoring
both
structural
integrity
functionality
affected
teeth.
Though
antimicrobial
remineralization
approaches
haven
shown
promise,
their
standalone
utilization
without
concurrent
bacterial
control
or
rebalancing
lacks
an
integrated
strategy
effectively
arrest
progression.
Furthermore,
according
principles
minimally
invasive
dentistry,
treatment
materials
should
exhibit
high
permeability
ensure
optimal
sealing
demineralized
tooth
surfaces.
concept
interrupting
(IDC)
has
emerged
as
holistic
approach,
drawing
upon
extensive
research
encompassing
three
pivotal
techniques:
antibacterial
strategies,
therapies,
infiltration
mechanisms,
all
which
are
indispensable
components
combating
progression
caries.
In
this
review,
we
provide
comprehensive
overview
mechanisms
applications
antibacterial,
remineralization,
technologies
within
context
management.
Additionally,
summarize
advanced
that
align
with
IDC
concept,
aiming
offer
valuable
insights
for
designing
next-generation
adept
at
preventing
halting
efficiently.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 7071 - 7097
Published: July 1, 2024
Abstract:
Whiskers
are
nanoscale,
high-strength
fibrous
crystals
with
a
wide
range
of
potential
applications
in
dentistry
owing
to
their
unique
mechanical,
thermal,
electrical,
and
biological
properties.
They
possess
high
strength,
modulus
elasticity
good
biocompatibility.
Hence,
adding
these
dental
composites
as
reinforcement
can
considerably
improve
the
mechanical
properties
durability
restorations.
Additionally,
whiskers
involved
inducing
value-added
differentiation
osteoblasts,
odontogenic
osteocytes,
pulp
stem
cells,
promoting
regeneration
alveolar
bone,
periodontal
tissue,
tissue.
also
enhance
mucosal
barrier
function,
inhibit
proliferation
tumor
control
inflammation,
aid
cancer
prevention.
This
review
comprehensively
summarizes
classification,
properties,
growth
mechanisms
preparation
methods
focuses
on
application
dentistry.
Due
physicochemical
excellent
nanoscale
characteristics,
show
great
for
periodontal,
tissue
regeneration.
they
be
used
prevent
treat
oral
medical
devices,
thus
making
them
promising
new
material
Keywords:
whiskers,
dentistry,
mechanism,
biomaterials
