Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: April 18, 2025
Macrophage activation induces rapid proliferation and division of fibroblast-like synovial cells (FLSs), resulting in the degradation cartilage matrix bone destruction, which are main pathological characteristics rheumatoid arthritis (RA). Inducing apoptosis these inflammatory to mitigate response alleviate damage is a potential therapeutic strategy for RA. In this study, we developed smart platform synergistic photothermal therapy (PTT) chemotherapy by utilizing hyaluronic acid (HA)-modified thermally sensitive liposomes loaded with celastrol (CEL) gold nanorods (GNRs), termed HA/Lipo-CEL-GNRs, application rat RA model. Under laser irradiation, GNRs exhibited excellent effects due localized surface plasmon resonance. The increase temperature not only effectively eliminated hyperproliferative joints but also triggered CEL release from thermosensitive liposomes, significantly increasing its concentration synovium. effect PTT promoted FLSs macrophages suppressed microenvironment. summary, multifunctional HA/Lipo-CEL-GNRs represent promising nanotherapeutic platforms capable achieving light-driven enrichment heat agents, preventing progression
Language: Английский
Citations
0
Exploration, Journal Year: 2025, Volume and Issue: unknown
Published: April 22, 2025
ABSTRACT Celastrol (CEL) is a natural pentacyclic triterpenoid demonstrating significant therapeutic properties against various diseases. However, the ambiguity of target information poses challenge in transitioning CEL from traditional remedy to modern pharmaceutical agent. Recently, emerging discovery approaches products have broadened extensive avenues for uncovering comprehensive and promoting its drug development. Herein, diverse strategies are overviewed pharmacological toxicological studies CEL, including chemical proteomics, protein microarray, degradation‐based profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based screening, multi‐omics analysis, hypothesis‐driven confirmation. Dozens targets been identified, which significantly suggests that functions as multi‐target Further interaction analysis frequency collected reveal PRDXs, HMGB1, HSP90, STAT3, PKM2 may serve key CEL. Additionally, this review highlights positive role facilitating CEL‐based combination therapy delivery, essential further advancing clinical applications Efforts identification not only aid unraveling scientific underpinnings multiple effects but also offer crucial insights development drugs.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: May 8, 2025
Rheumatoid arthritis (RA) is a classic autoimmune disease caused by combination of genetic and environmental factors. The multiple comprehensive pathologies involving the whole body's immune system local organs tissues make it challenging to control or cure them clinically. Fortunately, there are increasing reports that non-toxic low-toxicity natural products their derivatives (NP&TDs) have positive therapeutic effects on RA. This review focuses potential mechanisms NP&TDs against RA aims provide constructive information for developing rational clinical therapies. Active components can play palliative roles in through biological mechanisms. These primarily involve immunosuppressive, anti-inflammatory, autophagic, apoptotic pathways. Multiple targets- receptor-coupled signal transduction directly indirectly modulates nuclear transcription factors NF-κB, NFATc1, STAT3, HIF-1α, which turn regulate production several downstream pro-inflammatory cytokines, chemokines, immunocytes maturation differentiation, complexes, proliferation, apoptosis regulatory genes. Among these NP&TDs, tripterygium-type ingredients, artemisinin-type paeony-type ingredients been reported be mainstay treating Mechanistically, immunosuppression anti-inflammation still primary Nevertheless, direct binding targets pharmacodynamic require further in-depth studies.
Language: Английский
Citations
0
Bioactive Materials, Journal Year: 2025, Volume and Issue: 51, P. 1 - 45
Published: May 5, 2025
Language: Английский
Citations
0
Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101341 - 101341
Published: May 1, 2025
Language: Английский
Citations
0
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Journal Year: 2024, Volume and Issue: 16(4)
Published: July 1, 2024
Nanomedicines have significantly advanced the development of diagnostic and therapeutic strategies for various diseases, while they still encounter numerous challenges. Upon entry into human body, nanomedicines interact with biomolecules to form a layer proteins, which is defined as protein corona that influences biological properties nanomedicines. Traditional approaches primarily focused on designing stealthy evade biomolecule adsorption; however, due intricacies environment within this method cannot completely prevent adsorption. As research progresses, manipulating modulate in vivo behaviors has become focus. In review, modern influencing efficacy by corona, along their wide-ranging applications across diverse diseases are critically summarized, highlighted discussed. Finally, future directions important yet challenging area also briefly This article categorized under: Nanotechnology Approaches Biology > Nanoscale Systems Therapeutic Drug Discovery Emerging Technologies Biology-Inspired Nanomaterials Protein Virus-Based Structures.
Language: Английский
Citations
1
Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Citations
1