Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 249, P. 114489 - 114489
Published: Dec. 30, 2024
Language: Английский
Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 17(1)
Published: Nov. 27, 2024
Abstract Bioactive molecules have shown great promise for effectively regulating various bone formation processes, rendering them attractive therapeutics regeneration. However, the widespread application of bioactive is limited by their low accumulation and short half-lives in vivo. Hydrogels emerged as ideal carriers to address these challenges, offering potential prolong retention times at lesion sites, extend vivo mitigate side effects, avoid burst release, promote adsorption under physiological conditions. This review systematically summarizes recent advances development molecule-loaded hydrogels regeneration, encompassing applications cranial defect repair, femoral periodontal regeneration with underlying diseases. Additionally, this discusses current strategies aimed improving release profiles through stimuli-responsive delivery, carrier-assisted sequential delivery. Finally, elucidates existing challenges future directions hydrogel encapsulated field
Language: Английский
Citations
4
Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 2743 - 2765
Published: Feb. 1, 2025
The crosstalk between H-type endothelial cells (ECs) and macrophages is critical for maintaining angiogenesis osteogenesis in bone homeostasis. As core components of type H vessels, ECs respond to various pro-angiogenic signals, forming specialized vascular structures characterized by high expression platelet-endothelial cell adhesion molecule-1 (CD31) mucin (EMCN), thereby facilitating angiogenesis-osteogenesis coupling during formation. Macrophages, as key immune the perivascular region, are primarily classified into classically activated pro-inflammatory M1 phenotype selectively anti-inflammatory M2 phenotype, performing dual functions regulating local tissue homeostasis innate immunity. In recent years, complex vessel has garnered significant interest context bone-related diseases. Orderly regulation immunity provides a new direction preventing metabolic disorders such osteoporosis osteoarthritis. However, their interactions remain insufficiently understood, with limited clinical data available. This review comprehensively examines intricate diverse phenotypes, Insights signaling pathways that regulate crosstalk, focusing on roles osteogenesis. Furthermore, discusses interventions targeting this challenges remain. These insights may offer perspectives provide theoretical foundation developing novel therapeutic strategies.
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
Abstract Adipose‐derived stem cells (ADSCs) hold significant promise in bone tissue engineering due to their self‐renewal capacity and easy accessibility. However, limited osteogenic potential remains a critical challenge for clinical application repair. Emerging evidence suggests that circular RNAs (circRNAs) play key role regulating cell fate osteogenesis. Despite this, the specific mechanisms by which circRNAs influence ADSCs context of are largely unexplored. This study introduces novel strategy utilizing circAars, circRNA, modify ADSCs, then incorporated into gelatin methacryloyl (GelMA) hydrogels repair critical‐sized maxillofacial defects. The findings reveal circAars predominantly localizes cytoplasm where it acts as competitive sponge miR‐128‐3p, enhancing differentiation migration capabilities ADSCs. Furthermore, circAars‐engineered facilitate macrophage polarization from M1 M2 phenotype enhance endothelial (EC) angiogenic through paracrine mechanism. Additionally, GelMA scaffolds loaded with accelerate defects synergistically promoting osteogenesis, polarization, angiogenesis. approach offers promising therapeutic treatment
Language: Английский
Citations
0
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 4729 - 4757
Published: April 1, 2025
Bone tissue, the second most transplanted tissue after blood, is utilized in over 2.2 million bone grafts annually to address various bone-related conditions including fractures, tumors, infections, scoliosis, congenital defects, osteoporosis, osteoarthritis, and osteogenesis imperfecta. According incomplete statistics, $4.3 billion was spent on graft materials 2015 alone, with projections suggesting this figure may reach $66 by 2026. The limited availability of autogenous considered gold standard due their three critical biological properties: osteoconduction, osteoinduction, osteogenesis-alongside increasing global aging population, be contributing rising expenditure. Furthermore, advancements biomaterials engineering technologies have created opportunities for exploration new substitutes. In review, we will examine fundamental structure natural characteristics ideal graft, highlighting common currently available, such as true ceramics, decalcified matrix, freeze-dried demineralized bone, bioactive glasses, marrow aspirate concentrate, polymer nanocomposites, which different osteogenic, osteoconductivity, osteoinductivity, biocompatibility, mechanical properties, resorption. How utilize its advantages maximize osteogenic effect focus some current challenges field grafting identified, outlining potential directions future development. conclusion, choice repair regeneration, a comprehensive understanding disadvantages can improve effectiveness related surgical interventions.
Language: Английский
Citations
0
APL Materials, Journal Year: 2025, Volume and Issue: 13(4)
Published: April 1, 2025
Bone-related diseases caused by fractures, bone infection, cancer, and so on have posed a serious threat to human health. The drawbacks of traditional implants are gradually being solved through the design construction nanomaterials. Among them, black phosphorus (BP) is widely adopted in therapy due its excellent photo-responsiveness, biodegradability, biocompatibility, which considered as promising solution strategy. This latest review intended provide an elaborate introduction recent advances BP-contained nanomaterials for therapy, covers topics from strategies classified types osteogenic material, including 3D printing scaffolds, hydrogels, fibrous materials, others, well research works function BP also discussed. Finally, current status future prospects BP-based summarized reference further applications.
Language: Английский
Citations
0
Published: Jan. 1, 2025
Language: Английский
Citations
0
Frontiers in Molecular Biosciences, Journal Year: 2024, Volume and Issue: 11
Published: Sept. 11, 2024
Ferroptosis, an iron-ion-dependent process of lipid peroxidation, damages the plasma membrane, leading to non-programmed cell death. Osteoarthritis (OA), a prevalent chronic degenerative joint disease among middle-aged and older adults, is characterized by chondrocyte damage or loss. Emerging evidence indicates that ferroptosis plays role in OA development. However, most research has concentrated on regulation involving typical iron ions, potentially neglecting significance elevated copper ions both serum fluid patients with OA. This review aims fill this gap systematically examining interplay between metabolism, oxidative stress, ferroptosis, copper-associated death It will provide comprehensive overview ions' regulating their dual approach seeks offer new insights for further research, prevention, treatment
Language: Английский
Citations
3
Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 249, P. 114489 - 114489
Published: Dec. 30, 2024
Language: Английский
Citations
0