Extracellular Vesicle, Journal Year: 2024, Volume and Issue: 4, P. 100055 - 100055
Published: Nov. 6, 2024
Language: Английский
ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 24, 2025
Language: Английский
Citations
1
Smart Medicine, Journal Year: 2024, Volume and Issue: 3(3)
Published: July 25, 2024
Oral disease is a severe healthcare challenge that diminishes people's quality of life. Functional hydrogels with suitable biodegradability, biocompatibility, and tunable mechanical properties have attracted remarkable interest been developed for treating oral diseases. In this review, we present up-to-date research on the management dental caries, endodontics, periapical periodontitis, depending progression The strategies mucosal diseases salivary gland are then classified. After that, focus application related to tumor therapy tissue defects. Finally, review prospects restrictions perspectives utilization in treatment. We believe will promote advancement more amicable, functional personalized approaches
Language: Английский
Citations
5
Cell Transplantation, Journal Year: 2025, Volume and Issue: 34
Published: Jan. 1, 2025
Mesenchymal stem cells (MSCs) are pluripotent with self-renewal. They play a critical role in cell therapy due to their powerful immunomodulatory and regenerative effects. Recent studies suggest that one of the key therapeutic mechanisms MSCs seems derive from paracrine product, called extracellular vesicles (EVs). The EVs contain much DNA, messenger RNA (mRNA), microRNA, protein components, which can exert intracellular communication target cells. In clinical applications, MSC-EVs have been widely used tissue repair immune disorder diseases. However, there serval issues need be considered such as how accomplish large-scale production verify exact mechanism EVs. this review, we summarize current progress discuss challenges future MSC-EVs.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 380, P. 630 - 646
Published: Feb. 16, 2025
Language: Английский
Citations
0
Cell Communication and Signaling, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 2, 2025
Abstract Extracellular vesicles (EVs) and the extracellular matrix (ECM) are essential in maintaining bone joint health by facilitating intercellular communication, regulating tissue processes providing structural support. EVs with a large surface area carry diverse biomolecules to steer function of cells their surroundings. To understand how localize specific sites, we here review available knowledge on EV interactions ECM components that crucial for remodeling, cartilage maintenance, immune responses, playing roles both homeostasis pathological conditions, such as arthritis osteoporosis. More importantly, using analyses animal experimental data, illustrate effect ECM-based biomaterials (e.g. hydrogels, decellularized matrices, ECM-mimetic scaffolds) carriers toward effective delivery regenerative immunomodulatory therapies tissue. These enable sustained release targeted EVs, promoting regeneration. The insights this can be utilized advance development cutting-edge skeletal regeneration disease management.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 309, P. 142893 - 142893
Published: April 9, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 10, 2025
Orthopedic diseases pose significant challenges to public health due their high prevalence, debilitating effects, and limited treatment options. Additionally, orthopedic tumors, such as osteosarcoma, chondrosarcoma, Ewing sarcoma, further complicate the landscape. Current therapies, including pharmacological treatments joint replacement, address symptoms but fail promote true tissue regeneration. Cell-based which have shown successful clinical results in cancers other diseases, emerged a promising solution repair damaged tissues restore function tumors. This review discusses advances potential application of cell therapy for with particular focus on osteoarthritis, bone fractures, cartilage degeneration, We explore mesenchymal stromal cells (MSCs), chondrocyte transplantation, engineered immune induced pluripotent stem enhance regeneration by modulating response addressing inflammation. Ultimately, integration cutting-edge therapy, modulation, molecular targeting strategies could revolutionize providing hope patients seeking long-term solutions conditions.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: April 17, 2025
The repair of articular cartilage defects remains a major regenerative and clinical challenge. Exosomes (Exos) derived from mesenchymal stem cells (MSCs) have good application potential in tissue engineering. Numerous studies indicated that appropriate preconditioning methods can promote the therapeutic effect Exos. Growth differentiation factor 5 (GDF-5) plays critical role chondrogenesis regeneration. In this study, GDF-5 was used to precondition synovial (SMSCs) increase chondrogenic-promoting Exos (G-Exos). addition, we demonstrated G-Exos rich miR-383-3p increased chondrogenic SMSCs by activating Kdm2a/SOX2 signaling pathway. On basis, were loaded into glycyrrhizic acid/methacrylate-acylated hyaluronic acid (GA/HA/G-Exos) scaffold via digital light processing (DLP) bioprinting maintain bioactivity sustained release. GA/HA/G-Exos scaffolds not only presented significant biological properties vitro but also significantly promoted remodeling joint cavity microenvironment regeneration Sprague-Dawley rats. This study provides promising cell-free strategy for defect use engineered exofunctionalized scaffolds.
Language: Английский
Citations
0
Stem Cell Research & Therapy, Journal Year: 2024, Volume and Issue: 15(1)
Published: Oct. 1, 2024
Language: Английский
Citations
2
Platelets, Journal Year: 2024, Volume and Issue: 35(1)
Published: Oct. 21, 2024
Cartilage injury is common in orthopedics and cartilage tissue engineering provides a therapeutic direction for regeneration. Albumin (ALB)–platelet-rich fibrin (PRF) speculated to be an ideal natural scaffold material theoretically as product derived from human venous blood. Through vitro vivo experiments, it was demonstrated that ALB–PRF displayed porous structure slowly released growth factors (TGF-β1, PDGF-AA, PDGF-AB, PDGF-BB, EGF, IGF-1 VEGF), conditioned media promoted proliferation, migration, adhesion, phenotype maintenance extracellular matrix secretion of rabbit chondrocytes. Moreover, facilitated chondrogenesis vivo, the regenerative formed by ALB–PRF/chondrocytes histologically similar knee joint cartilage, expressed differentiation marker (SOX9, ACAN COL II), proliferation PCNA secreted abundant glycosaminoglycans (GAGs) matrix. In conclusion, chondrocytes vitro. Its loose, rich contained enhanced cell adhesion growing into materials. vivo.
Language: Английский
Citations
2