International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 10745 - 10765
Published: Oct. 1, 2024
Tissue
engineering
aims
to
recreate
natural
cellular
environments
facilitate
tissue
regeneration.
Gelatin
methacrylate
(GelMA)
is
widely
utilized
for
its
biocompatibility,
ability
support
cell
adhesion
and
proliferation,
adjustable
mechanical
characteristics.
This
study
developed
a
GelMA
graphene
bioink
platform
at
concentrations
of
1,
1.5,
2
mg/mL
enhance
scaffold
properties
applications.
Engineered Regeneration,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 1, 2024
Current
bioadhesive
dressings,
though
potential
in
wound
care,
often
exhibit
inadequate
adhesion
and
lack
essential
properties
for
optimal
healing,
such
as
being
antibacterial,
hemostatic,
angiogenic.
While
various
scaffolds
containing
natural
adhesive
molecules
3,4-dihydroxyphenyl-l-alanine
(DOPA)
tannic
acid
(TA)
have
been
individually
assessed,
the
comparison
of
adhesives
these
are
scarcely
studied.
This
study
addresses
limitations
by
developing
two
innovative
composite
hydrogel
adhesives,
based
on
DOPA
TA,
which
integrated
with
novel
multi-metal
bioactive
glass
nanoparticles
(BGNs).
A
comprehensive
their
was
conducted
to
evaluate
improving
healing
outcomes.
BGNs
were
synthesized
using
sol-gel
approach,
yielding
an
amorphous
porous
structure.
Incorporation
10%
w/w
uniform
distribution
enhanced
mechanical
both
hydrogels,
TA-based
dressings
demonstrating
superior
performance.
demonstrated
biocompatibility
hemocompatibility,
outperformed
DOPA-based
cell
viability
antibacterial
activity
against
Staphylococcus
aureus
Escherichia
coli,
while
composites
showed
better
vitro
angiogenic
hemostatic
capabilities.
Regarding
vivo
investigations,
mice
model
full-thickness
skin
wounds,
DOPA-
incorporated
dressing
contained
BGN
exhibited
slightly
performance
re-epithelialization,
collagen
formation
blood
vessel
density,
indicating
its
acute
applications.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Aug. 12, 2024
Tympanic
membrane
perforation
(TMP)
is
one
of
the
most
common
conditions
in
otolaryngology
worldwide,
and
hearing
damage
caused
by
inadequate
or
prolonged
healing
can
be
distressing
for
patients.
This
article
examines
rationale
utilizing
three-dimensional
(3D)
printing
to
produce
scaffolds
repairing
TMP,
compares
advantages
disadvantages
3D
printed
bioprinted
grafts
with
traditional
autologous
materials
other
tissue
engineering
TMP
repair,
highlights
practical
clinical
significance
repair
while
discussing
current
progress
promising
future
bioprinting.
There
a
limited
number
reviews
specifically
dedicated
repair.
The
majority
offer
general
overview
applications
broader
realm
regeneration,
some
mention
Alternatively,
they
explore
biopolymers,
cells,
drug
molecules
utilized
However,
more
in-depth
analysis
needed
on
strategies
selecting
bio-inks
that
integrate
tympanic
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Aug. 31, 2024
The
complex
anatomy
and
biology
of
craniofacial
bones
pose
difficulties
in
their
effective
precise
reconstruction.
Injectable
hydrogels
(IHs)
with
water-swollen
networks
are
emerging
as
a
shape-adaptive
alternative
for
noninvasively
rebuilding
bones.
advent
versatile
nanomaterials
(NMs)
customizes
IHs
strengthened
mechanical
properties
therapeutically
favorable
performance,
presenting
excellent
contenders
over
traditional
substitutes.
Structurally,
NM-reinforced
energy
dissipative
covalently
crosslinked,
providing
the
mechanics
necessary
to
support
structures
physiological
functions.
Biofunctionally,
incorporating
unique
NMs
into
IH
expands
plethora
biological
activities,
including
immunomodulatory,
osteogenic,
angiogenic,
antibacterial
effects,
further
favoring
controllable
dynamic
tissue
regeneration.
Mechanistically,
NM-engineered
optimize
physical
traits
direct
cell
responses,
regulate
intracellular
signaling
pathways,
control
release
biomolecules,
collectively
bestowing
structure-induced
features
multifunctionality.
By
encompassing
state-of-the-art
advances
NM-integrated
IHs,
this
review
offers
foundation
future
clinical
translation
bone
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 10745 - 10765
Published: Oct. 1, 2024
Tissue
engineering
aims
to
recreate
natural
cellular
environments
facilitate
tissue
regeneration.
Gelatin
methacrylate
(GelMA)
is
widely
utilized
for
its
biocompatibility,
ability
support
cell
adhesion
and
proliferation,
adjustable
mechanical
characteristics.
This
study
developed
a
GelMA
graphene
bioink
platform
at
concentrations
of
1,
1.5,
2
mg/mL
enhance
scaffold
properties
applications.
