Nanoparticle-Based Strategies for Managing Biofilm Infections in Wounds: A Comprehensive Review

ACS Omega, Journal Year: 2024, Volume and Issue: 9(26), P. 27853 - 27871

Published: June 17, 2024

Chronic wounds containing opportunistic bacterial pathogens are a growing problem, as they the primary cause of morbidity and mortality in developing developed nations. Bacteria can adhere to almost every surface, forming architecturally complex communities called biofilms that tolerant an individual's immune response traditional treatments. Wound dressings source potential treatment avenue for biofilm infections, research has recently focused on using nanoparticles with antimicrobial activity infection control. This Review categorizes nanoparticle-based approaches into four main types, each leveraging unique mechanisms against biofilms. Metallic nanoparticles, such silver copper, show promising data due their ability disrupt cell membranes induce oxidative stress, although effectiveness vary based particle size composition. Phototherapy-based utilizing either photodynamic or photothermal therapy, offer targeted microbial destruction by generating reactive oxygen species localized heat, respectively. However, efficacy depends presence light oxygen, potentially limiting use deeper more shielded Nanoparticles designed extracellular polymeric substances directly target structure, enhancing penetration agents. Lastly, dispersion represent novel strategy, aiming weaken biofilm's defense restore susceptibility antimicrobials. While method its advantages, selection appropriate specific requirements wound environment type involved. The integration these not only promises enhanced outcomes but also offers reduction overall antibiotics, aligning urgent need innovative solutions fight antibiotic-tolerant infections. overarching objective employing diverse nanoparticle strategies is replace antibiotics substantially reduce required dosages, providing avenues management.

Language: Английский

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Endogenous electric field coupling Mxene sponge for diabetic wound management: haemostatic, antibacterial, and healing

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Sept. 2, 2024

Improper management of diabetic wound effusion and disruption the endogenous electric field can lead to passive healing damaged tissue, affecting process tissue cascade repair. This study developed an extracellular matrix sponge scaffold (K1P6@Mxene) by incorporating Mxene into acellular dermal stroma-hydroxypropyl chitosan interpenetrating network structure. is designed couple with promote precise remodelling in wounds. The fibrous structure closely resembles that a natural matrix, providing conducive microenvironment for cells adhere grow, exchange oxygen. Additionally, inclusion enhances antibacterial activity(98.89%) electrical conductivity within scaffold. Simultaneously, K1P6@Mxene exhibits excellent water absorption (39 times) porosity (91%). It actively interacts guide cell migration growth on surface upon absorbing exudate. In vivo experiments, reduced inflammatory response wounds, increased collagen deposition arrangement, promoted microvascular regeneration, Facilitate expedited re-epithelialization minimize scar formation, accelerate wounds 7 days. Therefore, this scaffold, combined field, presents appealing approach comprehensive repair

Language: Английский

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Modern approaches to the use of ultrafine and nanoparticles as components of feed additives in poultry farming

World s Poultry Science Journal, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 40

Published: Feb. 18, 2025

Language: Английский

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The Antimicrobial Activity and Resistance Evolution of Nanomaterials: A Review

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1085 - 1111

Published: Feb. 19, 2025

Language: Английский

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Biofilm-Mediated Infections; Novel Therapeutic Approaches and Harnessing Artificial Intelligence for Early Detection and Treatment of Biofilm-Associated Infections

Microbial Pathogenesis, Journal Year: 2025, Volume and Issue: unknown, P. 107497 - 107497

Published: March 1, 2025

Language: Английский

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Preparation, characterization and antibacterial activities of bio-based schiff base Copper Complex intercalated montmorillonite

Applied Clay Science, Journal Year: 2025, Volume and Issue: 271, P. 107809 - 107809

Published: April 6, 2025

Language: Английский

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Phospholipids and phosphoprotein-encapsulated silver nanoparticles: An eco-friendly and green antibacterial agent for killing bacteria and promoting chronic wound healing

Journal of environmental chemical engineering, Journal Year: 2025, Volume and Issue: unknown, P. 116489 - 116489

Published: April 1, 2025

Language: Английский

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Bioactive Gold Nanoparticles Synthesized by Lactobacillus acidophilus for Catalytic and Antibacterial Applications

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

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Biologically inspired nanoformulations for the control of bacterial canker pathogens Clavibacter michiganensis subsp. michiganensis and subsp. capsici

Journal of Biotechnology, Journal Year: 2024, Volume and Issue: 392, P. 34 - 47

Published: June 24, 2024

Language: Английский

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Cellulose Acetate Membranes: Antibacterial Strategy and Application—A Review

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Developing antibacterial and biodegradable cellulose acetate (CA) membrane materials is one of the main challenges in multiple application fields. CA are widely used gas purification, water biomedical fields due to their environmental friendliness, high chemical mechanical stability, excellent processability, low cost. However, modification enhance utilization value process has always been direction researchers' efforts. This review focuses on preparation its derivatives membranes, especially types introduction methods agents. First, a brief CA-based polymer membranes presented, followed by an overview agent methods, mechanisms. After that, various prepared using polymers as matrix or additives discussed. Then, specific applications biomedical, food packaging, other outlined.

Language: Английский

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