Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings

Gels, Journal Year: 2025, Volume and Issue: 11(2), P. 123 - 123

Published: Feb. 7, 2025

Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.

Language: Английский

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Nanoparticle-Based Drug Delivery Systems in Inhaled Therapy: Improving Respiratory Medicine

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(8), P. 1059 - 1059

Published: Aug. 12, 2024

Inhaled nanoparticle (NP) therapy poses intricate challenges in clinical and pharmacodynamic realms. Recent strides have revolutionized NP technology by enabling the incorporation of diverse molecules, thus circumventing systemic clearance mechanisms enhancing drug effectiveness while mitigating side effects. Despite established success delivery oncology other disciplines, exploration inhaled therapies remains relatively nascent. NPs loaded with bronchodilators or anti-inflammatory agents exhibit promising potential for precise distribution throughout bronchial tree, offering targeted treatment respiratory diseases. This article conducts a comprehensive review applications medicine, highlighting their merits, ranging from heightened stability to exacting lung-specific delivery. It also explores cutting-edge technologies optimizing NP-loaded aerosol systems, complemented insights gleaned trials. Furthermore, examines current future prospects NP-based therapies. By synthesizing data perspectives, underscores transformative promise NP-mediated addressing chronic conditions such as obstructive pulmonary disease, pressing global health concern ranked third mortality rates. overview illuminates evolving landscape inhalation therapies, presenting optimistic avenues advancing medicine improving patient outcomes.

Language: Английский

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Biofilm Resilience: Molecular Mechanisms Driving Antibiotic Resistance in Clinical Contexts

Biology, Journal Year: 2025, Volume and Issue: 14(2), P. 165 - 165

Published: Feb. 6, 2025

Healthcare-associated infections pose a significant global health challenge, negatively impacting patient outcomes and burdening healthcare systems. A major contributing factor to healthcare-associated is the formation of biofilms, structured microbial communities encased in self-produced extracellular polymeric substance matrix. Biofilms are critical disease etiology antibiotic resistance, complicating treatment infection control efforts. Their inherent resistance mechanisms enable them withstand therapies, leading recurrent increased morbidity. This review explores development biofilms their dual roles disease. It highlights structural protective functions EPS matrix, which shields populations from immune responses antimicrobial agents. Key molecular biofilm including restricted penetration, persister cell dormancy, genetic adaptations, identified as barriers effective management. implicated various clinical contexts, chronic wounds, medical device-associated infections, oral complications, surgical site infections. prevalence hospital environments exacerbates challenges underscores urgent need for innovative preventive therapeutic strategies. evaluates cutting-edge approaches such DNase-mediated disruption, RNAIII-inhibiting peptides, DNABII proteins, bacteriophage nanoparticle-based solutions, coatings, lock therapies. also examines associated with biofilm-related diagnostic difficulties, disinfectant economic implications. emphasizes multidisciplinary approach importance understanding dynamics, role pathogenesis, advancements strategies combat biofilm-associated effectively settings. These insights aim enhance reduce burden diseases.

Language: Английский

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Electrospun Nanofibers with Antibacterial and Antioxidant Activities for Air Purification

ACS Applied Nano Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

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Foam-based antibacterial hydrogel composed of carboxymethyl cellulose/polyvinyl alcohol/cerium oxide nanoparticles for potential wound dressing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138924 - 138924

Published: Dec. 1, 2024

Language: Английский

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Nanoengineered Copper: Revolutionizing Breast Cancer Care

International Journal of Scientific Research in Science Engineering and Technology, Journal Year: 2025, Volume and Issue: 12(1), P. 164 - 180

Published: Feb. 3, 2025

Breast cancer continues to rank as a predominant cause of illness and death among women globally, emphasizing the critical need for innovative effective treatment approaches. Traditional methods such chemotherapy, surgery, radiation therapy often face limitations, including toxicity, resistance, non-specific targeting. In recent years, advancements in nanotechnology have brought about transformative solutions, with nanoengineered copper emerging frontrunner. Nanoengineered copper’s unique properties- its catalytic capabilities, biocompatibility, potential surface modification- offer unprecedented opportunities revolutionize breast care. These nanoparticles not only enable precise targeting cells but also improve diagnostic accuracy through advanced imaging techniques. Furthermore, their application photothermal photodynamic therapies provides dual approach destroying while minimizing harm healthy tissues. With ability modulate tumor microenvironment act platform combination therapies, holds immense promise both early detection treatment. This article explores wide-ranging applications copper, from innovations therapeutic breakthroughs, underscoring redefine management patient outcomes.

Language: Английский

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Biomaterials-based phototherapy for bacterial infections

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 4, 2024

Bacterial infections and antibiotic resistance are global health problems, current treatments for bacterial still rely on the use of antibiotics. Phototherapy based a photosensitizer has high efficiency, broad spectrum, strong selectivity, does not easily induce drug resistance, is expected to become an effective strategy treatment infections, particularly drug-resistant infections. This article reviews antimicrobial strategies phototherapy photosensitizers, including photodynamic therapy (PDT), photothermal (PTT), their combination. These methods have significant application potential in combating multi-drug-resistant biofilm providing alternative traditional antibiotics chemical antibacterial agents.

Language: Английский

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How Nanoparticles Help in Combating Chronic Wound Biofilms Infection?

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 11883 - 11921

Published: Nov. 1, 2024

Chronic wound infection has become a global health problem, with bacterial biofilms, which are difficult to penetrate using traditional antibiotics, considered the primary cause of recurrent and delayed healing in chronic wounds. In recent years, outstanding performance nanomaterials controlling biofilm infections been widely acknowledged, these materials regarded as highly promising for management. The formation structure biofilms undergo complex dynamic changes. Therefore, deep understanding underlying causes repeated specific antibacterial mechanisms at different stages is crucial effective "chronic management". This review first reveals relationship between chronicity, infections. Secondly, it focuses on four formation: (1) adhesion stage, (2) aggregation promotion (3) maturation (4) regeneration dissemination stage. It also comprehensively summarizes nanomaterials. study analyzes essential factors affecting control by nanoparticles from various perspectives, such material itself, local environment, systemic host response. Finally, limitations potential future trends current research discussed. summary, represent strategy combating infections, this provides new insights alternative adjuvant therapies managing

Language: Английский

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Biocompatibility Analysis of the Silver-Coated Microporous Titanium Implants Manufactured with 3D-Printing Technology

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(23), P. 1876 - 1876

Published: Nov. 22, 2024

3D-printed microporous titanium scaffolds enjoy good biointegration with the residuum's soft and bone tissues, they promote excellent biomechanical properties in attached prostheses. Implant-associated infection, however, remains a major clinical challenge. Silver-based implant coatings can potentially reduce bacterial growth inhibit biofilm formation, thereby reducing risk of periprosthetic infections. In current study, 1-µm thick silver coating was prepared on surface alloy physical vapor deposition (PVD), final content 1.00 ± 02 mg/cm

Language: Английский

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