Glutathione-Responsive Nanoplatforms Based on Coordination between Fe3+ and Apigenin for Synergistic Chemo/Chemodynamic Therapy DOI

Zhi-Hang He,

Hanxiao Tang,

Yanna Pan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

The oxygen consumption during chemodynamic therapy (CDT) can lead to severe cellular hypoxia, resulting in an increase the hypoxia inducible factor-1α (HIF-1α) level, which hinders effectiveness of CDT and induces tumor metastasis. Here, we propose a strategy synergistic between HIF-1α inhibitor avoid limitations reduce risk Herein, based on coordination Fe3+ apigenin (API, inhibitor), constructed hyaluronic acid (HA)-modified API-Fe nanoparticles (AF@HA NPs) for synergetic chemotherapy glutathione (GSH)-activated self-enhancing CDT. AF@HA NPs have high drug loading capacity, stability, biocompatibility. Furthermore, overexpressed GSH cancer cells Fe2+, weakened API Fe, promoted release chemotherapy. Fe2+ could react with endogenous H2O2 generate hydroxyl groups In addition, released inhibit expression sensitivity reactive species (ROS), thereby achieving effect results vitro vivo experiments indicated that effectively growth suppress lung metastasis cells.

Language: Английский

Surface Components and Biological Interactions of Extracellular Vesicles DOI
Jinping Wang, Kuoran Xing, Guo-Ying Zhang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Extracellular vesicles (EVs) are critical mediators of intercellular communication, carrying bioactive cargo and displaying diverse surface components that reflect their cellular origins functions. The EV surface, composed proteins, lipids, glycocalyx elements, plays a pivotal role in targeting recipient cells, mediating biological interactions, enabling selective delivery. This review comprehensively examined the molecular architecture surfaces, linking biogenesis to functional diversity, highlights therapeutic diagnostic potential diseases such as cancer cardiovascular disorders. Additionally, we explore emerging applications EVs, including machine-learning-assisted analysis, chemical integration, cross-system combinations. also discusses some key challenges clinical translation EV-related technologies.

Language: Английский

Citations

3
A multifunctional ROS cascade nanoplatform enables common prosperity of O2 and H2O2 for magnetic targeting and fluorescence imaging-guided photodynamic/chemodynamic therapy DOI

Linshan Jia,

Zimeng Zhou,

Xiaotong Li

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 506, P. 160178 - 160178

Published: Jan. 1, 2025

Language: Английский

Citations

1
Exosomes: a double‐edged sword in cancer immunotherapy DOI Creative Commons
Jiayi Chen,

Siyuan Hu,

Jiayi Liu

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: Feb. 17, 2025

Abstract Over the past few decades, immunotherapy has emerged as a powerful strategy to overcome limitations of conventional cancer treatments. The use extracellular vesicles, particularly exosomes, which carry cargoes capable modulating immune response, been extensively explored potential therapeutic approach in immunotherapy. Exosomes can deliver their cargo target cells, thereby influencing phenotype and immunomodulatory functions. They exhibit either immunosuppressive or immune‐activating characteristics, depending on internal contents. These exosomes originate from diverse cell sources, contents vary, suggesting that there may be delicate balance between suppression stimulation when utilizing them for Therefore, thorough understanding molecular mechanisms underlying role progression is essential. This review focuses driving exosome function impact tumor microenvironment (TME), highlighting intricate activation must navigated exosome‐based therapies. Additionally, it underscores challenges ongoing efforts optimize immunotherapies, making significant contribution advancement research.

Language: Английский

Citations

1
Novel therapeutic approaches for non-small cell lung cancer: an updated view DOI

Niloufar Orooji,

Shabnam Babaei,

Manouchehr Fadaee

et al.

Journal of drug targeting, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 29

Published: April 5, 2025

Non-small cell lung cancer (NSCLC) continues to be one of the leading causes cancer-related mortality globally. Most patients who undergo surgical procedures may encounter distant metastasis or local recurrence, necessitating supplementary treatments such as radiation therapy, chemotherapy, targeted therapy adjuvant alternatives. Recent advancements in molecular biology and immunotherapy have paved way for innovative therapeutic approaches that target specific genetic mutations promote immune response against tumor cells. This review explores emerging therapies, including therapies tyrosine kinase inhibitors (TKIs) actionable (e.g., EGFR, ALK, ROS1), well role checkpoint (ICIs) employ body's system combat cancer. Additionally, we discuss potential exosome promising nanotherapeutic options treatment NSCLC. study attempts provide a thorough overview changing landscape NSCLC its implications enhancing patient outcomes by presenting these techniques.

Language: Английский

Citations

1
MXene-reinforced bioactive polymer hydrogels for biomedical applications DOI Creative Commons

Guanghui Gu,

Xue Chen, Gang Wei

et al.

APL Materials, Journal Year: 2024, Volume and Issue: 12(8)

Published: Aug. 1, 2024

MXenes, a novel class of two-dimensional (2D) materials, have attracted considerable attention in various fields, especially drug delivery, wound healing, bone tissue engineering, biosensing, and cancer treatment. Thanks to their remarkable physicochemical properties, MXenes hold great promise for biomedical applications. Concurrently, hydrogels composed polymers been extensively utilized contexts. The unique properties facilitate integration into bioactive with enhanced functions thereby endowing the composites multifunctional capabilities. MXene-reinforced polymer (MRPHs) synergistically combine advantageous characteristics both hydrogels, making them highly adaptable other theranostic strategies medical In this comprehensive review, we demonstrate recent advances design synthesis MRPHs Specifically, introduce analyze methods tailoring by incorporating active components, including functional molecules, 2D metal ions, natural polymers, drugs/genes. We then discuss applications designed biosensors, therapy. hope that work provides valuable guidance inspiration readers develop advanced

Language: Английский

Citations

4
Recent Advances in Indocyanine Green-Based Probes for NIR-II Fluorescence Imaging and Therapy DOI Creative Commons
Dehong Hu,

Menglei Zha,

Hairong Zheng

et al.

Research, Journal Year: 2024, Volume and Issue: 8

Published: Dec. 27, 2024

Fluorescence imaging, a highly sensitive molecular imaging modality, is being increasingly integrated into clinical practice. Imaging within the second near-infrared biological window (NIR-II; 1,000 to 1,700 nm), also referred as shortwave infrared, has received substantial attention because of its markedly reduced autofluorescence, deeper tissue penetration, and enhanced spatiotemporal resolution compared traditional (NIR) imaging. Indocyanine green (ICG), US Food Drug Administration-approved NIR fluorophore, long been used in applications, including blood vessel angiography, vascular perfusion monitoring, tumor detection. Recent advancements NIR-II technology have revitalized interest ICG, revealing extended tail fluorescence beyond nm reaffirming potential clinically translatable fluorophore for vivo theranostic applications diagnosing various diseases. This review emphasizes notable advances use ICG derivatives image-guided therapy from both fundamental perspectives. We provide concise conclusion discuss challenges future opportunities with using approved fluorophores.

Language: Английский

Citations

4
Manganese Dioxide-based In Situ Vaccine Boosts Antitumor Immunity via Simultaneous Activation of Immunogenic Cell Death and the STING Pathway DOI

Peilan Peng,

Jiangjun Cao,

Wenting Cheng

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Enhancing Photodynamic Therapy Efficacy via Photo-Triggered Calcium Overload and Oxygen Delivery in Tumor Hypoxia Management DOI

Han Du,

Liang Zhang,

Jingjing Feng

et al.

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Background: Photodynamic therapy (PDT) has emerged as a promising treatment for cancer, primarily due to its ability generate reactive oxygen species (ROS) that directly induce tumor cell death. However, the hypoxic microenvironment commonly found within tumors poses significant challenge by inhibiting ROS production. This study aims investigate effect of improving hypoxia on enhancing PDT. Result: We employed polylactic-co-glycolic acid (PLGA) delivery vector encapsulation indocyanine green (ICG), photosensitizer, and perfluorohexane (PFH), with surface labeling mannose facilitate targeted delivery. A potential therapeutic nanoplatform was fabricated, designated Man-PFH-ICG@PLGA. These nanospheres are capable localizing at sites can be tracked using photoacoustic (PA) imaging. Upon laser irradiation, generated PDT activated transient receptor cation channel subfamily member 1 (TRPA1) located membrane. activation led an influx extracellular Ca2+ subsequently resulted in calcium overload. The excessive selectively accumulated mitochondria, disrupting function enzymes involved mitochondrial respiratory chain. disruption inhibits cellular respiration decreases consumption cells, ultimately contributing alleviation tumors. Simultaneously, PFH exhibited high affinity deliver exogenous site through simple diffusion along concentration gradient. Both direct indirect mechanisms synergistically contribute ameliorating conditions tumors, thereby augmenting efficacy Conclusions: synergistic photocontrolled overload from endogenous sources oxygen-carrying alleviates hypoxia, approach provides new perspective

Language: Английский

Citations

0
aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed ultrasound DOI Creative Commons
Yi Tang,

Qingling Shen,

Peng Lin

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 28, 2025

Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is challenging because its depth, which often leads to misdiagnosis during ultrasound examinations. The unique PDAC tumor microenvironment (TME) characterized by significant fibrous tissue growth, and high interstitial pressure hinders drug penetration into tumors. Additionally, hypoxia immune suppression within the contribute poor responses radiotherapy chemotherapy, ultimately leading an unfavorable prognosis. In this study, aPD-L1-modified docetaxel perfluoropentane-loaded liquid‒vapor phase-transformation lipid nanoparticles (aPDL1-DTX/PFP@Lipid) were synthesized had average diameter 61.63 nm with 84.3% antibody modification. We demonstrated that (NPs) exhibited excellent PDAC-targeting capabilities both in vitro vivo. Upon exposure low-intensity pulsed (LIPUS) stimulation, NPs underwent a phase transformation form microbubbles substantial molecular diagnostic effects, combined treatment resulted growth inhibition rate 88.91%. This strategy also led infiltration CD8+ T cells, downregulation Treg promotion M1 macrophage polarization, fibrosis reduce stromal pressure, facilitation perfluoropentane (PFP) gasification release O2 improve hypoxia. conclusion, loaded (DTX) PFP successfully for targeted PDAC. aPDL1-DTX/PFP@Lipid could reshape TME, offering new approach ultrasound-mediated promising clinical applications.

Language: Английский

Citations

0
Mechanisms and Applications of Manganese-Based Nanomaterials in Tumor Diagnosis and Therapy DOI Creative Commons
Xiaowen Ma, Chuan He, Yang Wang

et al.

Biomaterials Research, Journal Year: 2025, Volume and Issue: 29

Published: Jan. 1, 2025

Tumors are the second most common cause of mortality globally, ranking just below heart disease. With continuous advances in diagnostic technology and treatment approaches, survival rates some cancers have increased. Nevertheless, due to complexity mechanisms underlying tumors, cancer remains a serious public health issue that threatens population globally. Manganese (Mn) is an essential trace element for human body. Its regulatory role tumor biology has received much attention recent years. Developments nanotechnology led emergence Mn-based nanoparticles great potential use diagnosis cancers. nanomaterials can be integrated with conventional techniques, including chemotherapy, radiation therapy, gene augment their therapeutic effectiveness. Further, play synergistic emerging strategies such as immunotherapy, photothermal photodynamic electromagnetic hyperthermia, sonodynamic chemodynamic intervention therapy. Moreover, enhance both precision diagnostics capability combined treatment. This article examines roles associated Mn field physiology biology, focus on application prospects

Language: Английский

Citations

0