Synergistic Co-Assembly of Natural Oxidase and Peptide-Heme Nanozyme for In Situ H₂O₂ Removal with Enhanced Catalytic Efficiency and Stability

Nano Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Hydrogen peroxide, a byproduct of the oxidase catalytic process, significantly compromises enzymatic activity and stability natural oxidases, thereby restricting their industrial applications. To address this challenge, we developed coassembly system combining with peptide-heme (PepHeme) nanozyme possessing catalase-like on ferritin platform. This system, demonstrated by using choline galactose as models, forms an oxidase-catalase cascade reaction. Leveraging self-assembly properties directional association enabled sortase ligation, successfully constructed clusters oxidases PepHeme nanozymes. design facilitated immobilization enzymes nanozymes increased local concentration these clusters, thus enhancing both efficiency enzyme, especially hydrogen peroxide tolerance long-term stability. offers promising solution to issue in applications oxidases.

Language: Английский

Platinum nanozyme embedded in hyaluronate with multifunctional attributes synergistically promoting tracheal fistula healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 287, P. 138337 - 138337

Published: Dec. 5, 2024

Language: Английский