Antimicrobial peptide biological activity, delivery systems and clinical translation status and challenges

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 7, 2025

Antibiotic resistance is currently one of the most significant threats to global public health and safety. And studies have found that over next 25 years, 39 million people will die directly 169 indirectly due antibiotic-resistant diseases. Consequently, development new types antimicrobial drugs urgently needed. Antimicrobial peptides (AMPs) constitute an essential component innate immune response in all organisms. They exhibit a distinctive mechanism action endows them with broad spectrum biological activities, including antimicrobial, antibiofilm, antiviral, anti-inflammatory effects. However, AMPs also present certain limitations, such as cytotoxicity, susceptibility protein hydrolysis, poor pharmacokinetic properties, which impeded their clinical application. The delivery systems can address these challenges by modifying AMP enabling precise, controlled release at site infection or disease. This review offers comprehensive analysis mechanisms advantages AMPs. systematically evaluate how emerging drug systems, nanoparticles hydrogels, enhance stability bioavailability AMPs, discussing both strengths limitations. Moreover, unlike previous reviews, this highlight recent clinically approved AMP-based those development, emphasizing key translating into practice. With perspectives, it hoped provide some insights overcoming translational barriers advancing

Language: Английский

Bioactive Peptide-Based Composite Hydrogel for Myocardial Infarction Treatment: ROS Scavenging and Angiogenesis Regulation

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский