Graphene oxide nanoarchitectures in cancer biology: Nano-modulators of autophagy and apoptosis

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 354, P. 503 - 522

Published: Jan. 20, 2023

Language: Английский

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Research progress on carbon materials in tumor photothermal therapy

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 115070 - 115070

Published: June 28, 2023

At present, cancer remains one of the leading causes human death worldwide, and surgery, radiotherapy chemotherapy are still main methods treatment. However, these treatments have their drawbacks. Surgical treatment often struggles with complete removal tumor tissue, to a high risk recurrence. Additionally, drugs significant impact on overall health can easily result in drug resistance. The mortality other reasons promote scientific researchers unremittingly develop find more accurate faster diagnosis strategy effective method. Photothermal therapy, which utilizes near-infrared light, offers deeper tissue penetration minimal damage surrounding healthy tissues. Compared conventional methods, photothermal therapy boasts several advantages, including efficiency, non-invasiveness, simplicity, toxicity, fewer side effects. nanomaterials be categorized as either organic or inorganic materials. This review primarily focuses behavior carbon materials role Furthermore, challenges faced by discussed.

Language: Английский

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Chitosan- and hyaluronic acid-based nanoarchitectures in phototherapy: Combination cancer chemotherapy, immunotherapy and gene therapy

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 273, P. 132579 - 132579

Published: May 23, 2024

Language: Английский

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From the clinical perspective of photodynamic therapy and photothermal Therapy: Structure-Activity-Practice

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 507, P. 215733 - 215733

Published: March 1, 2024

Language: Английский

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Recent Trends in Bio-nanomaterials and Non-invasive Combinatorial Approaches of Photothermal Therapy against Cancer

Nanotheranostics, Journal Year: 2024, Volume and Issue: 8(2), P. 219 - 238

Published: Jan. 1, 2024

In 2020, approximately 10 million deaths worldwide were attributed to cancer, making it the primary cause of death globally.Photothermal therapy (PTT) is one novel ways treat and abolish cancer.PTT significantly impacts cancer theranostics compared other therapies like surgery, chemotherapy, radiotherapy due its remarkable binding capability tumor sites lower invasiveness into normal healthy tissues.PTT relies on photothermal agents (PTAs), which generate heat by absorbing near-infrared (NIR) light destroying cells.Several PTT remain longer in reticuloendothelial system (RES) induce toxicity, restricting their use biomedical field.To overcome this problem, usage biodegradable nano-photothermal required.This review has discussed mechanism action different types bio-nanomaterials used for PTT.We also focussed combinatorial effects with effect human health.The role LED lights mild hypothermia been briefly review.

Language: Английский

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Enhancing Photothermal/Photodynamic Therapy for Glioblastoma by Tumor Hypoxia Alleviation and Heat Shock Protein Inhibition Using IR820-Conjugated Reduced Graphene Oxide Quantum Dots

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(11), P. 13543 - 13562

Published: March 7, 2024

We use low-molecular-weight branched polyethylenimine (PEI) to produce cytocompatible reduced graphene oxide quantum dots (rGOQD) as a photothermal agent and covalently bind it with the photosensitizer IR-820. The rGOQD/IR820 shows high conversion efficiency produces reactive oxygen species (ROS) after irradiation near-infrared (NIR) light for photothermal/photodynamic therapy (PTT/PDT). To improve suspension stability, was PEGylated by anchoring DSPE hydrophobic tails in DSPE-PEG-Mal, leaving maleimide (Mal) end group covalent binding manganese dioxide/bovine serum albumin (MnO2/BSA) targeting ligand cell-penetrating peptide (CPP) synthesize rGOQD/IR820/MnO2/CPP. As MnO2 can react intracellular hydrogen peroxide alleviating hypoxia condition acidic tumor microenvironment, efficacy of PDT could be enhanced generating more cytotoxic ROS NIR light. Furthermore, quercetin (Q) loaded rGOQD through π–π interaction, which released endosomes act an inhibitor heat shock protein 70 (HSP70). This sensitizes cells thermal stress increases mild-temperature PTT irradiation. By simultaneously incorporating HSP70 situ (MnO2), rGOQD/IR820/MnO2/Q/CPP overcome limitation PTT/PDT enhance targeted phototherapy vitro. From vivo study orthotopic brain model, administered tail vein injection cross blood–brain barrier accumulate intracranial tumor, laser shrink prolong survival times animals enhancing treat glioblastoma.

Language: Английский

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Hyaluronic Acid-Modified Cisplatin-Encapsulated Poly(Lactic-co-Glycolic Acid) Magnetic Nanoparticles for Dual-Targeted NIR-Responsive Chemo-Photothermal Combination Cancer Therapy

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(1), P. 290 - 290

Published: Jan. 14, 2023

Combination chemo-photothermal therapy with nanomaterials can reduce the dose of chemotherapeutic drugs required for effective cancer treatment by minimizing toxic side effects while improving survival times. Toward this end, we prepare hyaluronic acid (HA)-modified poly(lactic-co-glycolic acid) (PLGA) magnetic nanoparticles (MNP) CD44 receptor-mediated and field-guided dual-targeted delivery cisplatin (CDDP). By co-encapsulating CDDP oleic acid-coated iron oxide MNP (IOMNP) in PLGA, PMNPc was first prepared a single emulsification/solvent evaporation step successively surface modified chitosan HA to HA/PMNPc. Spherical HA/PMNPc ~300 nm diameter be 18 10% (w/w) loading content IOMNP pH-sensitive drug release facilitate endosomal after intracellular uptake. This leads higher cytotoxicity toward U87 glioblastoma cells than free reduced IC50, cell apoptosis rate, enhanced expression marker proteins. Furthermore, show hyperthermia effect short-term near-infrared (NIR) light exposure, which further elevate apoptosis/necrosis rate upregulate HSP70 protein due photothermal effects. The combined therapeutic efficacy studied vivo using subcutaneously implanted nude mice. combination therapy, intravenously injected under field guidance followed NIR laser irradiation demonstrated most modality inhibiting tumor growth prolonging time tumor-bearing

Language: Английский

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Chitosan-coated magnetic graphene oxide for targeted delivery of doxorubicin as a nanomedicine approach to treat glioblastoma

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129401 - 129401

Published: Jan. 13, 2024

Language: Английский

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Graphene-Based Photodynamic Therapy and Overcoming Cancer Resistance Mechanisms: A Comprehensive Review

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 5637 - 5680

Published: June 1, 2024

Abstract: Photodynamic therapy (PDT) is a non-invasive that has made significant progress in treating different diseases, including cancer, by utilizing new nanotechnology products such as graphene and its derivatives. Graphene-based materials have large surface area photothermal effects thereby making them suitable candidates for PDT or photo-active drug carriers. The remarkable photophysical properties of derivates facilitate the efficient generation reactive oxygen species (ROS) upon light irradiation, which destroys cancer cells. Surface functionalization can also enhance their biocompatibility anticancer activity. paper delves into distinct roles played graphene-based photosensitizers (PS) carriers while at same time considers how these could be used to circumvent resistance. This will provide readers with an extensive discussion various pathways contributing inefficiency. Consequently, this comprehensive review underscores vital derivatives may play emerging strategies treatment other medical purposes. With better comprehension current state research existing challenges, integration holds great promise developing targeted, effective, personalized treatments. Keywords: quantum dots, oxide, research, photosensitizers, delivery

Language: Английский

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Reduced graphene oxide–reinforced tricalcium phosphate/gelatin/chitosan light-responsive scaffolds for application in bone regeneration

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 259, P. 129210 - 129210

Published: Jan. 4, 2024

Bone is a mineralized tissue with the intrinsic capacity for constant remodeling. Rapid prototyping techniques, using biomaterials that mimic bone native matrix, have been used to develop osteoinductive and osteogenic personalized 3D structures, which can be further combined drug delivery phototherapy. Herein, Fab@Home Plotter printer was promote layer-by-layer deposition of composite mixture gelatin, chitosan, tricalcium phosphate, reduced graphene oxide (rGO). The phototherapeutic potential new NIR-responsive 3D_rGO scaffolds assessed by comparing different rGO concentrations (1, 2, 4 mg/mL). data obtained show incorporation confers interact NIR light induce hyperthermy effect, maximum temperature increase 16.7 °C after under irradiation (10 min). Also, in content improved hydrophilicity mechanical resistance scaffolds, particularly 3D_rGO4. Furthermore, could confer an NIR-triggered antibacterial effect without compromising osteoblasts' proliferation viability. In general, support development being applied as temporary supporting formation avoiding establishment bacterial infections.

Language: Английский

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