Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 1, 2024
Aim:
To
analyze
the
effect
of
bioactive
bone
cement
(BBC)
placed
in
a
phosphate
buffer
saline
solution
comparison
to
mineral
trioxide
aggregate
(MTA).
Methodology:
Ten
samples
each
BBC
(group
1)
and
MTA
2)
were
prepared
stored
solution.
After
three
days
storage,
white
precipitates
formed
on
surface
samples.
The
with
from
sample
was
analyzed
for
presence
calcium
ions
coupled
plasma
atomic
spectroscopy.
Results:
showed
significant
amount
release
after
seven-day
storage
period
Calcium
significantly
higher
group
1
(MTA)
(p
<
0.001)
compared
that
2
(BBC),
while
exhibited
greater
Conclusion:
retains
its
bioactivity
when
it
comes
into
contact
stimulated
oral
environment
(STF).
This
demonstrates
is
simulated
environment.
Moreover,
retained
good
handling
properties
could
be
easily
manipulated
dough
form.
Clinically,
cases
apical
surgery,
internal
resorption
or
perforation
repair
where
material
placement
poses
difficulty,
will
prove
beneficial.
Current Issues in Molecular Biology,
Journal Year:
2024,
Volume and Issue:
46(1), P. 585 - 611
Published: Jan. 5, 2024
Numerous
surgeries
are
carried
out
to
replace
tissues
that
have
been
harmed
by
an
illness
or
accident.
Due
various
surgical
interventions
and
the
requirement
of
bone
substitutes,
emerging
field
tissue
engineering
attempts
repair
damaged
with
help
scaffolds.
These
scaffolds
act
as
template
for
regeneration
controlling
development
new
cells.
For
creation
functional
organs,
there
three
elements
play
very
crucial
role:
cells,
signals
achievement
these
aims,
types
natural
polymers,
like
chitosan,
chitin,
cellulose,
albumin
silk
fibroin,
used
preparation
Scaffolds
produced
from
polymers
many
advantages:
they
less
immunogenic
well
being
biodegradable,
biocompatible,
non-toxic
cost
effective.
The
hierarchal
structure
bone,
microscale
nanoscale,
is
mostly
made
up
organic
inorganic
components
nanohydroxyapatite
collagen
components.
This
review
paper
summarizes
knowledge
updates
information
about
use
scaffolds,
their
application
in
recent
research
trends
area
(BTE).
article
extensively
explores
related
analyze
advancement
nanotechnology
treatment
bone-related
diseases
repair.
Materials,
Journal Year:
2023,
Volume and Issue:
16(11), P. 4017 - 4017
Published: May 27, 2023
Interest
in
calcium
phosphate
cements
as
materials
for
the
restoration
and
treatment
of
bone
tissue
defects
is
still
high.
Despite
commercialization
use
clinic,
have
great
potential
development.
Existing
approaches
to
production
drugs
are
analyzed.
A
description
pathogenesis
main
diseases
(trauma,
osteomyelitis,
osteoporosis
tumor)
effective
common
strategies
presented
review.
An
analysis
modern
understanding
complex
action
cement
matrix
additives
distributed
it
relation
successful
given.
The
mechanisms
biological
functional
substances
determine
effectiveness
certain
clinical
cases.
important
direction
using
a
carrier
volumetric
incorporation
anti-inflammatory,
antitumor,
antiresorptive
osteogenic
substances.
functionalization
requirement
prolonged
elution.
Various
release
factors
related
matrix,
elution
conditions
considered
work.
It
shown
that
system.
Changing
one
many
initial
parameters
wide
range
changes
final
characteristics
and,
accordingly,
kinetics.
Advanced Therapeutics,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 12, 2025
Abstract
The
incidence
of
type
2
diabetes
(T2DM)
increases
significantly
worldwide.
Due
to
consistent
hyperglycemia,
insulin
resistance,
and
chronic
inflammation,
T2DM
patients
encounter
osteoporosis
induced
osteoporotic
fracture
risks.
Antidiabetic
drugs
have
been
traditional
therapies
that
seek
control
blood
glucose,
balance
bone
metabolism,
favor
systemic
immunosuppression.
However,
such
impact
quality
its
nano‐scale
features
in
the
long‐term.
Today,
biomedical
experts
are
continuously
advancing
drug
delivery
tools
for
local
osteo‐immunomodulatory
agents
T2DM.
It
is
demonstrated
bioavailability
release
profile
determine
osteoconductivity
outcomes
therapeutics.
This
review
focuses
on
introducing
currently
used
vehicles
fabrication
techniques
biomaterial‐based
systems
thoroughly
examined.
Furthermore,
feasibility
potential
factors
contributing
bioactive
surveyed.
extent
vivo
responses
described
context
current
research
examples.
Targeted
signaling
mechanisms
also
assessed
detail
elucidate
activated
healing
routes.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(5), P. 680 - 680
Published: May 1, 2023
This
study
aims
to
compare
the
anti-osteoporotic
drugs
alendronic
acid
(ALN)
and
flufenamic
(FA)
alone
impregnate
into
nanoparticles
of
mesoporous
bioactive
glass
(nMBG),
which
further
composites
calcium
phosphate
cement
(CPC)
investigates
their
in
vitro
performance.
The
drug
release,
physicochemical
properties,
biocompatibility
nMBG@CPC
composite
bone
are
tested,
effect
on
improving
proliferation
differentiation
efficiency
mouse
precursor
osteoblasts
(D1
cells)
is
also
investigated.
Drug
release
shows
that
FA
impregnates
composite,
a
large
amount
released
rapidly
within
8
h,
gradually
reaching
stable
12
followed
by
slow
sustained
14
days,
then
reaches
plateau
21
days.
phenomenon
confirms
drug-impregnated
nBMG@CPC
effectively
achieves
delivery.
working
time
setting
each
4-10
min
10-20
min,
respectively,
meeting
operational
requirements
clinical
applications.
addition
nMBG
CPC
matrix
did
not
prevent
aggregation
under
microstructural
observation,
thus
resulting
decrease
strength
composite.
However,
after
24
h
immersed
reaction,
5
wt.%
impregnated
with
different
concentrations
ALN
still
greater
than
30
MPa,
higher
general
trabecular
strength.
hinder
product
formation
exhibit
biocompatibility.
Based
mineralization
D1
cells,
combination
abundant
conducive
cells.
when
cells
contact
cultured
for
alkaline
phosphatase
(ALP)
enzyme
activity
ALP
secretion
from
drug-free
composites.
Accordingly,
this
can
anti-osteoporosis
ALN,
enhance
ability
osteoblasts.
Furthermore,
applications
be
used
or
as
new
option
osteoporotic
bone-filling
surgery.
Journal of Cellular Physiology,
Journal Year:
2024,
Volume and Issue:
239(5)
Published: April 9, 2024
Osteosarcoma
(OS)
cancer
treatments
include
systemic
chemotherapy
and
surgical
resection.
In
the
last
years,
novel
treatment
approaches
have
been
proposed,
which
employ
a
drug-delivery
system
to
prevent
offside
effects
improves
efficacy.
Locally
delivering
anticancer
compounds
on
high
local
concentrations
with
more
efficient
tumour-killing
effect,
reduced
drugs
resistance
confined
effects.
Here,
synthesis
of
injectable
strontium-doped
calcium
phosphate
(SrCPC)
scaffold
was
proposed
as
drug
delivery
combine
bone
tissue
regeneration
by
controlled
release
methotrexate
(MTX)
doxorubicin
(DOX),
coded
SrCPC-MTX
SrCPC-DOX,
respectively.
The
drug-loaded
cements
were
tested
in
an
vitro
model
human
OS
cell
line
SAOS-2,
engineered
(SAOS-2-eGFP)
U2-OS.
ability
doped
scaffolds
induce
death
apoptosis
assessed
analysing
proliferation
Caspase-3/7
activities,
To
determine
if
cells
grown
doped-scaffolds
change
their
migratory
invasiveness,
wound-healing
assay
performed.
addition,
osteogenic
potential
SrCPC
material
evaluated
using
adipose
derived-mesenchymal
stem
cells.
Osteogenic
markers
such
(i)
mineral
matrix
deposition
analysed
alizarin
red
staining;
(ii)
osteocalcin
(OCN)
protein
expression
investigated
enzyme-linked
immunosorbent
test,
(iii)
process
studied
real-time
polymerase
chain
reaction
array.
induced
cell-killing
cytotoxic
lines
up
Day
7.
demonstrates
good
cytocompatibility
it
upregulation
genes
involved
skeletal
development
pathway,
together
OCN
deposition.
approach,
based
local,
sustained
from
nanostructured
biomimetic
is
promising
for
future
therapies
aiming
therapy.
