Nanoscale, Journal Year: 2023, Volume and Issue: 16(4), P. 1792 - 1806
Published: Dec. 13, 2023
Graphene-based nerve conduits for peripheral regeneration. Interaction with non-neuronal cell types: neutrophils and mesenchymal stem cells.
Language: Английский
Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: 24(5)
Published: Jan. 15, 2024
Abstract Spinal cord injuries are very common worldwide, leading to permanent nerve function loss with devastating effects in the affected patients. The challenges and inadequate results current clinical treatments scientists innovative neural regenerative research. Advances nanoscience tissue engineering have opened new avenues for spinal injury (SCI) treatment. In order designed guidance conduit (NGC) be functionally useful, it must ideal scaffold properties topographic features that promote linear orientation of damaged axons. this study, is aimed develop channeled polycaprolactone (PCL)/Poly‐D,L‐lactic‐co‐glycolic acid (PLGA) hybrid film scaffolds, modify their surfaces by IKVAV pentapeptide/gold nanoparticles (AuNPs) or polypyrrole (PPy) investigate behavior motor neurons on vitro under static/bioreactor conditions. Their potential regeneration after implantation into rat SCI shaping scaffolds modified factors a tubular form also examined. It shown groups decorated AuNPs highly neurite bioreactor conditions developed optimal NGC (PCL/PLGA G1‐IKVAV/BDNF/NGF‐AuNP 50 ) regenerates SCI. indicate can an candidate regeneration.
Language: Английский
Citations
7
Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(44), P. 11302 - 11335
Published: Jan. 1, 2024
Enhancing cell-material interactions through surface engineering to create biomimetic environments and extend implant life.
Language: Английский
Citations
4
Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(1)
Published: Jan. 1, 2025
ABSTRACT Silicone rubbers, such as polydimethylsiloxane (PDMS), have been widely used in biotechnology and medical science because of their excellent properties. However, microfabrication silicone rubbers remains to be problematic the high viscosity adhesiveness (tackiness) rubber, making it difficult fill molds reproduce shapes during soft lithography. Also, patterns made rubber are prone pattern collapse. To address these, we designed molecules that can modified by radiation whose hardness adjusted after microfabrication. By combining materials with different chemical structures molecular weights, developed a low suitable for modification. The synthesized had filling ability micropatterned adhesiveness, which prevented Moreover, elastic modulus controlled using high‐energy electron beam (EB) irradiation. radiation‐modified sheet retained its transparency visible light, oxygen permeability, drug adsorption adhesion. utilizing these characteristics, new technique was produces microfabricated hydrophilicity imprinting technology followed EB Soft lithography then performed on transfer micropillar structure. Pillar were accurately fabricated diameter 1.0 μm or less along mold, is fabricate conventional PDMS. This overcomes problems associated promising material high‐performance microdevices.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142578 - 142578
Published: March 1, 2025
Language: Английский
Citations
0
Biomimetics, Journal Year: 2025, Volume and Issue: 10(4), P. 213 - 213
Published: March 31, 2025
Peripheral nerve injuries (PNIs) pose significant challenges to recovery, often resulting in impaired function and quality of life. To address these challenges, guidance conduits (NGCs) are being developed as effective strategies promote regeneration by providing a supportive framework that guides axonal growth facilitates reconnection severed nerves. Among the materials explored, graphene-based (GBMs) have emerged promising candidates due their unique properties. Their properties—such high mechanical strength, excellent electrical conductivity, favorable biocompatibility—make them ideal for applications repair. The integration 3D printing technologies further enhances development GBM-based NGCs, enabling creation scaffolds with complex architectures precise topographical cues closely mimic natural neural environment. This customization significantly increases potential successful review offers comprehensive overview properties GBMs, principles printing, key design 3D-printed NGCs. Additionally, it discusses future perspectives research directions could advance application GBMs therapies.
Language: Английский
Citations
0
Tissue Engineering Part B Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: April 21, 2025
The study of the human nervous system remains challenging due to its inherent complexity and difficulty in obtaining original samples. Three-dimensional (3D) bioprinting is a rapidly evolving technology field tissue engineering that has made significant contributions several disciplines, including neuroscience. In order more accurately reflect intricate multicellular milieu vivo environment, an increasing number studies have commenced experimentation with coprinting diverse cell types. This article provides overview technical details application 3D multiple types neuroscience, focusing on challenges research conducted based printing. review discusses interactions systems, stem applications, construction brain-like organoids, establishment disease models, potential for integrating other culture techniques.
Language: Английский
Citations
0
Engineering materials, Journal Year: 2025, Volume and Issue: unknown, P. 293 - 320
Published: Jan. 1, 2025
Language: Английский
Citations
0
BioMedical Engineering OnLine, Journal Year: 2024, Volume and Issue: 23(1)
Published: April 6, 2024
Abstract Severely damaged peripheral nerves will regenerate incompletely due to lack of directionality in their regeneration, leading loss nerve function. To address this problem, various guidance conduits (NGCs) have been developed provide for repair. However, clinical application is still limited, mainly because its effect promoting repair not as good autologous transplantation. Therefore, it necessary enhance the ability NGCs promote directional growth. Strategies include preparing structures on contact guidance, and loading substances them electrical stimulation or neurotrophic factor concentration gradient physical biological signals.
Language: Английский
Citations
3
Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: unknown
Published: June 17, 2024
Tissue repair and regeneration, such as bone nerve restoration, face significant challenges due to strict regulations within the immune microenvironment, stem cell differentiation, key behaviors. The development of 3D scaffolds is identified a promising approach address these issues via efficiently structural on fates In particular, 3D-printed polymer with diverse micro-/nanostructures offer great potential for mimicking structures tissue. Consequently, they are foreseen promissing pathways regulating fates, including phenotype, differentiation cells, well migration proliferation thereby facilitating tissue repairs regenerations. Herein, roles functions in behaviors numerous cells related along their specific influences highlighted. Additionally, outlooks associated various modulating also discussed.
Language: Английский
Citations
2
Stem Cell Reviews and Reports, Journal Year: 2024, Volume and Issue: 20(7), P. 1752 - 1781
Published: July 27, 2024
Language: Английский
Citations
1