A Zn-MOF-GOx-based cascade nanoreactor promotes diabetic infected wound healing by NO release and microenvironment regulation

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 182, P. 245 - 259

Published: May 9, 2024

Language: Английский

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CX3CL1 (Fractalkine)-CX3CR1 Axis in Inflammation-Induced Angiogenesis and Tumorigenesis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4679 - 4679

Published: April 25, 2024

The chemotactic cytokine fractalkine (FKN, chemokine CX3CL1) has unique properties resulting from the combination of chemoattractants and adhesion molecules. soluble form (sFKN) strongly attracts T cells monocytes. membrane-bound (mFKN) facilitates diapedesis is responsible for cell-to-cell adhesion, especially by promoting strong leukocytes (monocytes) to activated endothelial with subsequent formation an extracellular matrix angiogenesis. FKN signaling occurs via CX3CR1, which only known member CX3C receptor subfamily. Signaling within FKN-CX3CR1 axis plays important role in many processes related inflammation immune response, often occur simultaneously overlap. upregulated hypoxia and/or inflammation-induced inflammatory release, it may act locally as a key angiogenic factor highly hypoxic tumor microenvironment. importance FKN/CX3CR1 pathway tumorigenesis cancer metastasis results its influence on cell apoptosis, migration. This review presents context angiogenesis cancer. mechanisms determining pro- or anti-tumor effects are presented, cause seemingly contradictory that create confusion regarding therapeutic goals.

Language: Английский

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Enhanced wound regeneration by PGS/PLA fiber dressing containing platelet-rich plasma: an in vitro study

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: May 26, 2024

Abstract Novel wound dressings with therapeutic effects are being continually designed to improve the healing process. In this study, structural, chemical, physical, and biological properties of an electrospun poly glycerol sebacate/poly lactide acid/platelet-rich plasma (PGS/PLA-PRP) nanofibers were evaluated determine its impacts on in vitro healing. Results revealed desirable cell viability Fibroblast (L929) macrophage (RAW-264.7) lines as well human umbilical vein endothelial cells (HUVEC). Cell migration was evident scratch assay (L929 line) so that it promoted contraction accelerate Moreover, addition PRP fiber structure led enhanced collagen deposition (~ 2 times) comparison PGS/PLA scaffolds. While by fibers not only decreased expression levels pro-inflammatory cytokines (IL-6 TNF-α) RAW-264.7 but also significantly increased cytokine (IL-10) growth factor (TGF-β), which related anti-inflammatory phase (M2 phenotype). Finally, PGS/PLA-PRP found induce a significant level angiogenesis forming branching points, loops, tubes. Based results obtained, dressing developed might be promising evolution skin tissue engineering ensuring improved regeneration.

Language: Английский

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Carboxymethyl cellulose/Sodium alginate Hydrogel with Anti-inflammatory capabilities for Accelerated Wound healing; In vitro and In vivo study

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: 976, P. 176671 - 176671

Published: May 24, 2024

Language: Английский

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Electrospun chitosan/polycaprolactone wound dressing containing henna extract and vitamin C: A natural composite for wound care

Polymer Engineering and Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract The present study shows an incredibly promising wound dressing material based on electrospun chitosan (CS)/polycaprolactone (PCL) fibers that are enhanced with henna extract (HE) and vitamin C (VitC). incorporation of HE, a traditional medicinal herb known for its healing capabilities, Vit C, powerful antioxidant, into CS takes use CS's natural biocompatibility antibacterial characteristics. This combination requires to generate synergistic effect enhances provides protection against infection. scaffolds were created investigated determine their surface morphology, chemical composition, ability water swelling, strength, kill bacteria. results indicate the inclusion HE substantially improved absorbing water, which is essential encouraging attachment cells maintaining moisture, both critical wounds. Furthermore, containing shown significant efficacy Escherichia coli Staphylococcus aureus , demonstrating capacity prevent According in vitro evaluation, sample 1 wt% VitC exhibited exceptional cell adhesion L929 fibroblast line. introduces innovative has customized mixture substances. approach addresses gaps previous CS/PCL studies, introducing composite advanced care applications. Highlights Electrospun CS/PCL‐HE/VitC potential. improve antimicrobial properties. scaffold demonstrates moisture retention application. activity E. S. aureus. In studies show excellent cells.

Language: Английский

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Building effective nanocarriers based on β-ionone loaded 2nd and 3rd generation L-arginine dendrimers: In vitro evaluation of cytotoxicity and antiproliferative activity for HeLa cells

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 44, P. 102545 - 102545

Published: Jan. 25, 2025

Language: Английский

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Systemic Trafficking of Macrophages in Implant Wear Debris-Induced Periprosthetic Osteolysis

SLAS TECHNOLOGY, Journal Year: 2025, Volume and Issue: unknown, P. 100254 - 100254

Published: Feb. 1, 2025

Periprosthetic osteolysis (PPOL) is a significant complication post-joint replacement, often instigated by implant wear debris, leading to chronic inflammation and bone resorption. Herein, this review summarizes the immune mechanisms of PPOL, specifically, processes where macrophages are recruited which trigger inflammatory cascades, role chemokines that facilitate macrophage migration, including CCL2, CCL3, CCL4, CCL5, CXCL8, CX3CL1, XCL1. This highlights novel findings on these suggests illustrating offers promising avenues for future therapeutic strategies prevent treat such as potential use anti-inflammatory drugs.

Language: Английский

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Light-triggered release of nitric oxide from chitosan-based cationic hydrogels for promoting infected wounds healing

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140998 - 140998

Published: Feb. 12, 2025

Language: Английский

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Chitosan/poly (β‐amino ester) hydrogel by controlled release of Centella Asiatica promoted wound healing through improved collagen expression and antibacterial and anti‐inflammatory properties

Polymer Engineering and Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Abstract Burn wound healing presents several challenges, including impaired collagen synthesis, delayed closure, and disrupted inflammatory responses. This study investigates the potential of a novel UV‐crosslinked hydrogel made chitosan (CS)/poly(β‐amino ester) (PβAE) Centella Asiatica extract (CA) for second‐degree burn treatment. Among various formulations, monomer ratio 1.5:1 5 wt% 2,2‐dimethoxy‐2‐phenyl‐acetophenone DMPA crosslinker concentration were found optimal. The achieved ~74% controlled release CA over 72 h showed significant enhancement in fibroblast viability (123.66 ± 9% at days). Scratch assay demonstrated ~99.5% closure within 24 h. Collagen type I expression was increased by ~1.7‐fold compared with control. Additionally, exhibited remarkable anti‐inflammatory properties, effectively modulating response. It significantly reduced pro‐inflammatory markers such as IL‐6 TNF‐α while simultaneously enhancing levels cytokines, IL‐10 TGF‐β. dual action not only mitigates inflammation but also fosters regenerative environment, further supporting process promoting tissue recovery. antibacterial properties inhibition zones ~19.1 mm E. coli ~12.4 S. aureus . These results suggest that this biocompatible, biodegradable is promising therapeutic candidate wounds. Highlights Developed chitosan/PβAE burns. Optimized releases Boosts viability, migration, 1.7x. Reduces IL‐6, TNF‐α, IL‐10, Strong against aureus.

Language: Английский

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Preparation and characterization of an antibacterial CMC/PCL hydrogel films containing CIP/Cur: In vitro and in vivo evaluation of wound healing activity

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136570 - 136570

Published: Oct. 15, 2024

Language: Английский

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