A Versatile Composite Hydrogel with Spatiotemporal Drug Delivery of Mesoporous ZnO and Recombinant Human Collagen for Diabetic Infected Wound Healing DOI

Ye Wu,

Cheng Hu, Yaxing Li

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Diabetic wounds are increasingly common and challenging to treat due high infection risks in a high-glucose environment. Effective treatment requires wound dressings that combat infections, while promoting angiogenesis skin regeneration. This study presents hydrogel-based drug delivery system made from cellulose designed accelerate diabetic healing by eliminating bacterial infections. The hydrogel, formed linking phenylboronic acid-grafted oxidized methylcellulose (POMC) with poly(vinyl alcohol) (PVA), exhibits self-healing injectable properties. It is further enhanced adding type I recombinant human collagen (rhCOL1) stimulate cell growth mesoporous zinc oxide (mZnO) for antibacterial anti-inflammatory effects. Upon application, the hydrogel degrades under pH/ROS stimuli, releasing mZnO rhCOL1 controlled manner matches stages. In vivo tests show effectively eliminates bacteria, reduces inflammation, promotes rapid regeneration, making it promising solution treating wounds.

Language: Английский

Cutting-Edge Hydrogel Technologies in Tissue Engineering and Biosensing: An Updated Review DOI Open Access
Nargish Parvin, Vineet Kumar, Sang Woo Joo

et al.

Materials, Journal Year: 2024, Volume and Issue: 17(19), P. 4792 - 4792

Published: Sept. 29, 2024

Hydrogels, known for their unique ability to retain large amounts of water, have emerged as pivotal materials in both tissue engineering and biosensing applications. This review provides an updated comprehensive examination cutting-edge hydrogel technologies multifaceted roles these fields. Initially, the chemical composition intrinsic properties natural synthetic hydrogels are discussed, highlighting biocompatibility biodegradability. The manuscript then probes into innovative scaffold designs fabrication techniques such 3D printing, electrospinning, self-assembly methods, emphasizing applications regenerating bone, cartilage, skin, neural tissues. In realm biosensing, hydrogels’ responsive nature is explored through integration optical, electrochemical, piezoelectric sensors. These sensors instrumental medical diagnostics glucose monitoring, pathogen detection, biomarker identification, well environmental industrial like pollution food quality monitoring. Furthermore, explores cross-disciplinary innovations, including use wearable devices, hybrid systems, potential personalized medicine. By addressing current challenges future directions, this aims underscore transformative impact advancing healthcare practices, thereby providing a vital resource researchers practitioners field.

Language: Английский

Citations

7
Exploring the potential of polysaccharides-based injectable self-healing hydrogels for wound healing applications: A review DOI
Seyed Morteza Naghib,

Amir Matini,

Saba Amiri

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137209 - 137209

Published: Nov. 4, 2024

Language: Английский

Citations

5
Engineering Polymers: From Biodegradable Platforms to Intelligent Drug Carriers DOI

Jasleen Kaur Minhas,

V. D. Aher, Sushmitha Bujji

et al.

Polymer-Plastics Technology and Materials, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 27

Published: April 4, 2025

Language: Английский

Citations

0
Latest progress of self-healing hydrogels in cardiac tissue engineering DOI
Lidia Maeso,

Tatiane Eufrásio-da-Silva,

Enes Deveci

et al.

Biomedical Microdevices, Journal Year: 2024, Volume and Issue: 26(3)

Published: Aug. 16, 2024

Language: Английский

Citations

2
Efficient Synthesis and Characterization of Antibacterial Xanthan Gum–Based Self‐Healing Hydrogels: Conventional Versus Microwave Treated DOI

Homa Etemadi Moghaddam,

Mahsa Baghban Salehi

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Dec. 1, 2024

ABSTRACT The development of self‐healing hydrogels with mechanical integrity is vital for biomedical applications. This study synthesizes multi‐network (MN) using xanthan gum (XG) through conventional and microwave‐assisted methods via free‐radical polymerization. synthesis materials included XG, acrylamide, acrylonitrile, sodium dodecyl sulfate, ferric chloride hexahydrate, ammonium persulfate. Conventional took 60 min at 70°C, while microwave was completed in 4.5 540 W, enhancing energy material efficiency. Structural tests like FTIR SEM confirmed the results. Microwave produced a layered structure smaller pores, leading to slower swelling kinetics, EDX mapping showed higher Fe 3+ ion concentrations, indicating better crosslinking. Thermal gravimetric analysis demonstrated that degradation onset temperatures were 184°C XG hydrogel (MHXG) 163°C water bath method (HXG), 20°C enhancement due coherent induced by treatment. Evaluation capabilities visual rheological significant enhancements MHXG, which exhibited time 2 h compared 1 day required HXG, attributed increased crosslink density hydrogen bonding facilitated Rheological assessments both types maintained their structural viscoelastic properties after healing. MHXG strength 21.12 kPa elasticity 10 kPa, whereas HXG 11.59 respectively. Microwave‐treated enhanced antibacterial effectiveness against Staphylococcus aureus distribution agents matrix. synthesizing XG‐based promising advanced

Language: Английский

Citations

1
Multifunctional hydrogels for the healing of oral ulcers DOI Open Access

W B Zhang,

Jie Zhao,

Xinxin Zou

et al.

Journal of Biomedical Materials Research Part A, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 29, 2024

Oral ulcers are one of the most common oral diseases in clinical practice. Its etiology is complex and varied. Due to dynamic nature environment, wound surface painful due contact wear, which seriously affects quality life patients. often treated with topical drug therapy. Studies have shown that functional hydrogels play a positive role promoting healing, showing unique advantages dressings. In this paper, causes healing characteristics discussed depth, then treatment methods for summarized compared. Finally, potential projected through review literature recent years.

Language: Английский

Citations

0
A Versatile Composite Hydrogel with Spatiotemporal Drug Delivery of Mesoporous ZnO and Recombinant Human Collagen for Diabetic Infected Wound Healing DOI

Ye Wu,

Cheng Hu, Yaxing Li

et al.

Biomacromolecules, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Diabetic wounds are increasingly common and challenging to treat due high infection risks in a high-glucose environment. Effective treatment requires wound dressings that combat infections, while promoting angiogenesis skin regeneration. This study presents hydrogel-based drug delivery system made from cellulose designed accelerate diabetic healing by eliminating bacterial infections. The hydrogel, formed linking phenylboronic acid-grafted oxidized methylcellulose (POMC) with poly(vinyl alcohol) (PVA), exhibits self-healing injectable properties. It is further enhanced adding type I recombinant human collagen (rhCOL1) stimulate cell growth mesoporous zinc oxide (mZnO) for antibacterial anti-inflammatory effects. Upon application, the hydrogel degrades under pH/ROS stimuli, releasing mZnO rhCOL1 controlled manner matches stages. In vivo tests show effectively eliminates bacteria, reduces inflammation, promotes rapid regeneration, making it promising solution treating wounds.

Language: Английский

Citations

0