Advances in Smart-Response Hydrogels for Skin Wound Repair

Polymers, Journal Year: 2024, Volume and Issue: 16(19), P. 2818 - 2818

Published: Oct. 5, 2024

Hydrogels have emerged as promising candidates for biomedical applications, especially in the treatment of skin wounds, a result their unique structural properties, highly tunable physicochemical and excellent biocompatibility. The integration smart-response features into hydrogels allows dynamic responses to different external or internal stimuli. Therefore, this paper reviews design smart-responsive microenvironments field wound therapy. First, three typical chronic difficult-to-heal wounds key mechanisms affecting healing therapeutic measures are outlined. Strategies construction stimulus-responsive (e.g., pH, ROS, enzymes, glucose) temperature, light, electricity, magnetic fields) highlighted from perspective microenvironment vitro environment, constitutive relationships between material design, intelligent response, revealed. Finally, discusses severe challenges faced by during repair provides an outlook on combination artificial intelligence give scientific direction creating using hydrogel dressings that respond stimuli clinic.

Language: Английский

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Advances in the development of medical dressings for the treatment of diabetic foot wounds

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 498, P. 155575 - 155575

Published: Sept. 7, 2024

Language: Английский

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Visualization of the Relationship Between Hyaluronic Acid and Wound Healing: A Bibliometric Analysis

Skin Research and Technology, Journal Year: 2025, Volume and Issue: 31(2-5)

Published: Feb. 1, 2025

ABSTRACT Background Wound healing is a complex process with significant economic implications. Hyaluronic acid (HA), valued for its adaptability and biocompatibility, shows the potential to improve multiple facets of wound healing. Despite expanding literature on use HA in care, comprehensive analysis scholarly evolution lacking. This study employs bibliometric approach objectively evaluate trends publications regarding HA's role promoting Methods We searched Web Science Core Collection (WoSCC) articles published from January 1, 2000 March 31, 2024. extracted relevant information about using promote following thorough screening process. Subsequently, was undertaken total 1886 publications. The utilized GraphPad Prism 9, CiteSpace6.1.6, VOSviewer1.6.19, Online Analysis Platform Literature Metrology ( http://bibliometric.com/ ), GeneMANIA https://genemania.org/ Metascape https://metascape.org/gp/index.html#/main/step1 ). Results retrieved 2424 hyaluronic (HA) Collection, covering period 2024, selected analysis. results show increase since 2016, reflecting growing focus this field. Currently, China's publication volume has surpassed United States 2017, indicating rise influence area. Using CiteSpace software co‐citation analysis, we identified eight main research clusters, including promoted healing, injured tissue, advanced multi‐targeted composite biomaterial. Key areas involve mechanisms tissue repair, particularly applications growth factor production regenerative therapy. Analyzing keyword co‐occurrence burst data VOSviewer, hotspots focused biomaterials, such as nanoparticles hydrogels, their antibacterial properties. “CD44” showed long period, while “antibacterial” had highest intensity 2022. top 21 genes extensively studied CD44, VEGF, TGF‐β. These are mainly involved regulating cell migration, adhesion, proliferation, cytokine activity. GO enrichment KEGG pathway analyses indicate that these associated key signaling pathways, MAPK EGFR, revealing primary promotes Conclusion pioneering provides first Covering it reveals expansion annual production. Current emphasizes development HA‐based biomaterials enhancing

Language: Английский

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Roles of MMP-2 and MMP-9 and their associated molecules in the pathogenesis of keloids: a comprehensive review

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 25, 2024

Keloid scars (keloids), a prototypical form of aberrant scar tissue formation, continue to pose significant therapeutic challenge within dermatology and plastic surgery due suboptimal treatment outcomes. Gelatinases are subgroup matrix metalloproteinases (MMPs), family enzymes that play an important role in the degradation remodeling ECM (a pivotal factor for keloids development). include gelatinase A (MMP-2) B (MMP-9). Since accumulating evidence has shown gelatinases played crucial process keloid we summarized current knowledge on association between MMP-2 MMP-9 expression pathological through comprehensive review. This review demonstrated interplay MMP-2, MMP-9, their regulators, such as TGF-β1/Smad, PI3K/AKT, LncRNA-ZNF252P-AS1/miR-15b-5p/BTF3 signaling cascades, involved intricate balance governing homeostasis, collectively driving excessive collagen deposition altered architecture observed keloids. In summary, this consolidates understanding pathogenesis, shedding light involvement dysregulated processes. The potential targeted interventions presents promising opportunities advancing management strategies.

Language: Английский

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Allergic Diseases and T2DM:A Bidirectional Multivariable Mendelian Randomization Study and Mediation Analysis

Journal of Asthma, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 19

Published: Nov. 14, 2024

Clinical studies involving observation have uncovered a mutual relationship between allergic disorders and diabetes, yet the precise causal link remains undetermined.

Language: Английский

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