Interactive effects of ARRB2 and CHRNA5 genetic polymorphisms on cognitive function in Chinese male methamphetamine use disorder patients DOI
Leina Jiang, Dongmei Wang, Yang Tian

et al.

American Journal on Addictions, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Background and Objectives Both β‐arrestin2 nicotinic acetylcholine receptor (nAChR) have been implicated in cognitive processes, particularly relation to psychiatric disorders, including addiction. Previous studies suggested that nAChR may be regulated by β‐arrestin2. However, no study has investigated the interaction of on cognition. We aimed examine main interactive effects their respective encoding genes, ARRB2 CHRNA5 , function MUD patients. Methods recruited 559 patients with methamphetamine use disorder (MUD) 459 healthy controls, assessed functioning using Chinese version Repeatable Battery for Assessment Neuropsychological Status (RBANS), genotyped rs1045280 rs3829787 polymorphisms Results Compared scored significantly lower all RBANS indexes. Neither nor had patients, but there were significant between two single nucleotide (SNPs) multiple indexes, immediate memory, visuospatial/constructional, delayed total score. In detail, among carriers T allele, TT higher scores than C allele carriers, whereas CC genotype, performed worse RBANS. Conclusions Scientific Significance Our identified first time an effect which would enlarge our knowledge genetic function.

Language: Английский

Z-Ligustilide: A Potential Therapeutic Agent for Atherosclerosis Complicating Cerebrovascular Disease DOI Creative Commons

Longyu Shen,

Qianqian Tian,

Qiqi Ran

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(12), P. 1623 - 1623

Published: Dec. 18, 2024

Atherosclerosis (AS) is one of the major catalysts ischemic cerebrovascular disease, and death disease burden from AS its complications are increasing. Z-ligustilide (Z-LIG) a key active ingredient in Angelica sinensis (Oliv.) Diels Ligusticum chuanxiong Hort. In this paper, we first introduced LIG’s physicochemical properties pharmacokinetics. Then, reviewed Z-LIG’s intervention therapeutic mechanisms on complications. The Z-LIG include improving lipid metabolism, antioxidant anti-inflammatory effects, protecting vascular endothelium, inhibiting endothelial fibrosis, pathological thickening, plaque calcification. diseases complicated by AS, exerts practical neuroprotective effects stroke (IS), transient attack (TIA), dementia (VaD) through anti-neuroinflammatory, anti-oxidation, anti-neuronal apoptosis, protection blood-brain barrier, promotion mitochondrial division angiogenesis, improvement cholinergic activity, inhibition astrocyte proliferation, endoplasmic reticulum stress. This paper aims to provide basis for subsequent studies prevention treatment and, thus, promote development interventional drugs AS.

Language: Английский

Citations

2
Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease DOI Open Access
Érica Novaes Soares, Ana Carla dos Santos Costa,

Gabriel de Jesus Ferrolho

et al.

Published: March 4, 2024

Parkinson’s disease (PD) is a progressive neurodegenerative characterized by resting tremor, bradykinesia, rigidity, postural instability, that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) the primary neurotransmitter involved in this disease, but cholinergic imbalance has been implicated. Current intervention PD focused on replenishing central DA, which provides remarkable temporary symptomatic relief does not address neuronal loss and progression of disease. It well established nicotinic receptors (nAChRs) can regulate DA release nicotine itself may have neuroprotective effects. Recent studies identified nAChRs nonneuronal cell types including glial cells, where they inflammatory responses. Given crucial role neuroinflammation dopaminergic degeneration, involvement microglia astrocytes response, provide novel therapeutic target prevention and/or treatment PD. In review, following brief discussion PD, we focus cells specifically their pathology treatment.

Language: Английский

Citations

1
The role of Nrf2 signaling pathways in nerve damage repair DOI
Arash Abdolmaleki, Aida Karimian, Seyedeh Mahdieh Khoshnazar

et al.

Toxicology Research, Journal Year: 2024, Volume and Issue: 13(3)

Published: May 1, 2024

Abstract The protein, Nuclear factor-E2-related factor 2 (Nrf2), is a transitory protein that acts as transcription and involved in the regulation of many cytoprotective genes linked to xenobiotic metabolism antioxidant responses. Based on existing clinical experimental data, it can be inferred neurodegenerative diseases are characterized by an excessive presence markers oxidative stress (OS) reduced defense systems both brain peripheral tissues. imbalances homeostasis between oxidants antioxidants has been recognized substantial pathogenesis disorders. dysregulations include several cellular processes such mitochondrial failure, misfolding, neuroinflammation. These all contribute disruption proteostasis neuronal cells, leading their eventual mortality. A noteworthy component Nrf2, shown recent research undertaken over last decade, its role development resistance OS. Nrf2 plays pivotal regulating defend against Extant offers substantiation for protective defensive roles context diseases. purpose this study provide comprehensive analysis influence OS function within realm Furthermore, we evaluate most academic inquiries empirical evidence about beneficial potential certain activator compounds therapeutic interventions.

Language: Английский

Citations

1
Immune Cell Ion Channels as Therapeutic Targets DOI

Anna Selezneva,

Alasdair J. Gibb, Dean Willis

et al.

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 461 - 495

Published: Jan. 1, 2024

Language: Английский

Citations

1
Affinity ultrafiltration based metabolomic profiling directed discovery novel butyrylcholinesterase inhibitors from Uncaria sessilifructus DOI
Chang Xu, Xiaoyan Yu, Guiyang Wang

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 277, P. 134179 - 134179

Published: July 30, 2024

Language: Английский

Citations

0
Novel interplay between agonist and calcium binding sites modulates drug potentiation of α7 acetylcholine receptor DOI Creative Commons
Nuriya Mukhtasimova, Cecilia Bouzat, Steven M. Sine

et al.

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: Aug. 7, 2024

Drug modulation of the α7 acetylcholine receptor has emerged as a therapeutic strategy for neurological, neurodegenerative, and inflammatory disorders. is homo-pentamer containing topographically distinct sites agonists, calcium, drug modulators with each type site present in five copies. However, functional relationships between agonist, modulator remain poorly understood. To investigate these relationships, we manipulated number agonist binding sites, monitored potentiation ACh-elicited single-channel currents through receptors by PNU-120596 (PNU) both presence absence calcium. When ACh alone, it elicits brief, sub-millisecond channel openings, however when PNU long clusters potentiated openings. In harboring potentiates regardless or whereas one site, but not By varying numbers calcium show that depends on balance occupancy orthosteric allosteric sites. The findings suggest local cellular environment, fluctuations concentrations neurotransmitter may alter this modulate ability to potentiate α7.

Language: Английский

Citations

0
Proteome of Clothianidin Exposed Honey Bees Reveals a Possible Mechanism Behind Impairment of Sucrose Responsiveness DOI Creative Commons
Nadejda Tsvetkov, Kyung‐Mee Moon, Leonard J. Foster

et al.

Journal of Applied Entomology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

ABSTRACT Neonicotinoids (NNIs) are the most commonly used insecticides in world and clothianidin, a type of NNI, is found honey bee collected pollen. Clothianidin has several negative effects on health behaviour, but whether how it might impact learning memory remains unclear. Therefore, we exposed workers to field‐realistic oral dose clothianidin for 7 days assess their sugar responsiveness, olfactory using proboscis extension response paradigm. Sugar responsiveness impacts important colony‐level traits, such as onset foraging, that help maintain colony homeostasis well memory. We then measured alters protein expression brain an effort understand mechanism(s) clothianidin's effects. Clothianidin‐exposed bees had impaired no effect was seen identified 5069 groups showed fewer detectable proteins. The also mitochondrial respiration proteins, reduced levels nicotinic acetylcholine receptor α7 (nAChRα7) subunit (one targets clothianidin) acetylcholinesterase acetylcholinesterase‐2 levels. In bees, nAChRα7 positively correlated with providing evidence possible mechanical explanation.

Language: Английский

Citations

0
Interactive effects of ARRB2 and CHRNA5 genetic polymorphisms on cognitive function in Chinese male methamphetamine use disorder patients DOI
Leina Jiang, Dongmei Wang, Yang Tian

et al.

American Journal on Addictions, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 15, 2024

Abstract Background and Objectives Both β‐arrestin2 nicotinic acetylcholine receptor (nAChR) have been implicated in cognitive processes, particularly relation to psychiatric disorders, including addiction. Previous studies suggested that nAChR may be regulated by β‐arrestin2. However, no study has investigated the interaction of on cognition. We aimed examine main interactive effects their respective encoding genes, ARRB2 CHRNA5 , function MUD patients. Methods recruited 559 patients with methamphetamine use disorder (MUD) 459 healthy controls, assessed functioning using Chinese version Repeatable Battery for Assessment Neuropsychological Status (RBANS), genotyped rs1045280 rs3829787 polymorphisms Results Compared scored significantly lower all RBANS indexes. Neither nor had patients, but there were significant between two single nucleotide (SNPs) multiple indexes, immediate memory, visuospatial/constructional, delayed total score. In detail, among carriers T allele, TT higher scores than C allele carriers, whereas CC genotype, performed worse RBANS. Conclusions Scientific Significance Our identified first time an effect which would enlarge our knowledge genetic function.

Language: Английский

Citations

0