International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(2), P. 1786 - 1786
Published: Jan. 16, 2023
The
emerging
concept
of
cancer
stem
cells
(CSCs)
as
the
key
driver
behind
carcinogenesis,
progression,
and
diversity
has
displaced
prior
model
a
tumor
composed
with
similar
subsequently
acquired
mutations
an
equivalent
capacity
for
renewal,
invasion,
metastasis.
This
significant
change
shifted
research
focus
toward
targeting
CSCs
to
eradicate
cancer.
may
be
characterized
using
cell
surface
markers.
They
are
defined
by
their
self-renew
differentiate,
resist
conventional
therapies,
generate
new
tumors
following
repeated
transplantation
in
xenografted
mice.
CSCs'
functional
capabilities
governed
various
intracellular
extracellular
variables
such
pluripotency-related
transcription
factors,
internal
signaling
pathways,
external
stimuli.
Numerous
natural
compounds
synthetic
chemicals
have
been
investigated
ability
disrupt
these
regulatory
components
inhibit
stemness
terminal
differentiation
CSCs,
hence
achieving
clinical
implications.
However,
no
treatment
focuses
on
biological
consequences
drugs
functions
established.
article
provides
biomedical
discussion
at
time
along
overview
origin,
features,
characterization,
isolation
techniques,
novel
targeted
therapeutic
approaches.
Additionally,
we
highlighted
factors
endorsed
controlling
or
helping
promote
CSCs.
Our
objective
was
encourage
future
studies
prospective
treatments
develop
framework
application
single
combined
therapeutics
forms
Cancers,
Journal Year:
2019,
Volume and Issue:
11(5), P. 597 - 597
Published: April 29, 2019
Lung
cancer
is
one
of
the
leading
causes
cancer-related
death
worldwide.
Non-small
cell
lung
(NSCLC)
around
80%
to
90%
deaths.
The
lack
an
early
diagnosis
and
inefficiency
in
conventional
therapies
poor
prognosis
overall
survival
patients.
Recent
progress
nanomedicine
has
encouraged
development
alternative
theranostics
strategy
using
nanotechnology.
interesting
physico-chemical
properties
nanoscale
have
generated
immense
advantages
for
nanoparticulate
systems
detection
active
delivery
drugs
a
better
cancer.
This
present
review
provides
detailed
overview
recent
application
nanoparticles
including
liposomes,
polymeric,
metal
bio-nanoparticles.
Further,
we
summarize
disadvantages
each
approach
considering
improvement
theranostics.
Expert Opinion on Drug Delivery,
Journal Year:
2016,
Volume and Issue:
14(1), P. 123 - 136
Published: July 12, 2016
Metastatic
breast
cancer
is
one
of
the
most
devastating
cancers
that
have
no
cure.
Many
therapeutic
and
diagnostic
strategies
been
extensively
studied
in
past
decade.
Among
these
strategies,
nanotechnology
has
emerged
as
a
promising
strategy
preclinical
studies
by
enabling
early
identification
primary
tumors
metastases,
effective
killing
cells.
Areas
covered:
This
review
covers
recent
progress
made
targeting
imaging
metastatic
with
nanoparticles,
treatment
using
nanoparticle-enabled
chemo-,
gene,
photothermal-
radio-therapies.
also
discusses
developments
stem
cell
therapy
immunotherapy.
Expert
opinion:
Nanotechnology
expected
to
play
important
roles
modern
for
cancers,
including
cancer.
Nanoparticles
are
able
target
visualize
metastasis
various
organs,
deliver
agents.
Through
cells,
nanoparticles
treat
resistant
minimal
toxicity
healthy
tissues/organs.
activate
immune
cells
eliminate
tumors.
Owing
their
multifunctional,
controllable
trackable
features,
nanotechnology-based
could
be
highly
potent
approach
future
research
treatment.
Theranostics,
Journal Year:
2020,
Volume and Issue:
10(3), P. 1181 - 1196
Published: Jan. 1, 2020
Cancer
stem
cells
(CSCs)
have
been
implicated
in
cancer
recurrence
and
therapy
resistance.
Therefore,
a
CSC-targeted
that
disrupts
the
maintenance
survival
of
CSCs
may
offer
an
effective
approach
killing
tumor
primary
tumors
preventing
metastasis
caused
by
CSCs.
Nanoparticles
(NPs)-based
thermotherapy
and/or
chemotherapy
are
promising
therapeutic
methods
for
treatment.
Methods:
A
silica-based
multifunctional
NP
system
was
present,
which
encapsulated
chemotherapeutic
agent
magnetic
cores
coated
with
specific
antibody
against
lung
The
efficacy
this
novel
strategy
systematically
studied
both
vitro
vivo
simultaneous
activating
combined
via
NPs.
Results:
These
NPs
were
administered
activated
targeted
using
externally
applied
alternating
field
(AMF).
antibody-modified
to
enhanced
cellular
uptake
extended
accumulation
vivo.
Up
98%
killed
30-min
application
AMF,
due
effects
hyperthermia
drug
In
models,
significantly
suppressed
growth
CSC
xenograft-bearing
mice,
minimal
side
adverse
effects.
Conclusion:
With
good
biocompatibility
targeting
capability,
nanodrug
delivery
clinical
platform
chemotherapy.
This
work
demonstrated
feasibility
developing
nanomedicine
Journal of Nanobiotechnology,
Journal Year:
2018,
Volume and Issue:
16(1)
Published: March 16, 2018
Silver
and
photothermal
therapy
(PTT)
have
been
widely
used
for
eradicating
the
drug-resistant
bacteria.
However,
risks
of
excess
silver
humans
low
efficiency
PTT
still
limit
their
in
vivo
therapeutic
application.
Integration
two
distinctive
bactericides
into
one
entity
is
a
promising
platform
to
improve
antimicrobial
agents.In
this
study,
chemo-photothermal
based
on
polydopamine
(PDA)-coated
gold
nanorods
(GNRs)
was
developed.
The
PDA
coating
acquired
high
Ag+
ions
loading
Cy5-SE
fluorescent
agent
labeled
glycol
chitosan
(GCS)
conjugation
(Ag+-GCS-PDA@GNRs).
This
became
positively
charged
pH
environment
abscess,
allowing
accumulation
local
infection
site
as
revealed
by
thermal/florescence
imaging.
loaded
released
pH-sensitive
manner,
resulting
selective
delivery
abscess
(pH
~
6.3).
More
importantly,
ultralow
dose
could
effectively
damage
bacterial
membrane,
causing
permeability
increase
heat
resistance
reduction
cell
leading
large
improvement
bactericidal
PTT.
On
other
hand,
hyperthermia
trigger
more
release,
further
chemotherapy.
Combinational
chemo-hyperthermia
Ag+-GCS-PDA@GNRs
thoroughly
ablate
accelerate
wound
healing
via
synergistic
antibacterial
effect.Our
studies
demonstrate
that
robust
practical
use
chemo-thermal
focal
with
outstanding
bacteria
ablating.
