Recent Advances in Single Fe-Based Nanoagents for Photothermal–Chemodynamic Cancer Therapy DOI Creative Commons
Li Zhang, Helen Forgham, Ao Shen

et al.

Biosensors, Journal Year: 2022, Volume and Issue: 12(2), P. 86 - 86

Published: Jan. 31, 2022

Monomodal cancer therapies are often unsatisfactory, leading to suboptimal treatment effects that result in either an inability stop growth and metastasis or prevent relapse. Thus, synergistic strategies combine different therapeutic modalities improve performance have become the new research trend. In this regard, integration of photothermal therapy (PTT) with chemodynamic (CDT), especially PTT/CDT second near-infrared (NIR-II) biowindow, has been demonstrated be a highly efficient relatively safe concept. With rapid development nanotechnology, nanoparticles can designed from specific elements, such as Fe, equipped both PTT CDT functions. review, we provide update on recent advances Fe-based nanoplatforms for combined PTT/CDT. The perspectives further improvement curative efficiency described, highlighting important scientific obstacles require resolution order reach greater heights clinical success. We hope review will inspire interest researchers developing novel nanomedicines multifunctional theranostics.

Language: Английский

Multidrug Resistance (MDR): A Widespread Phenomenon in Pharmacological Therapies DOI Creative Commons
Alessia Catalano, Domenico Iacopetta, Jessica Ceramella

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(3), P. 616 - 616

Published: Jan. 18, 2022

Multidrug resistance is a leading concern in public health. It describes complex phenotype whose predominant feature to wide range of structurally unrelated cytotoxic compounds, many which are anticancer agents. may be also related antimicrobial drugs, and known one the most serious global health threats this century. Indeed, phenomenon has increased both mortality morbidity as consequence treatment failures its incidence healthcare costs. The large amounts antibiotics used human therapies, well for farm animals even fishes aquaculture, resulted selection pathogenic bacteria resistant multiple drugs. not negligible that ongoing COVID-19 pandemic further contribute resistance. In paper, multidrug underlined, focusing on therapeutic options overcome these obstacles drug treatments. Lastly, some recent studies nanodrug delivery systems have been reviewed since they represent significant approach overcoming

Language: Английский

Citations

295
Natural Products as Anticancer Agents: Current Status and Future Perspectives DOI Creative Commons
Abid Naeem,

Pengyi Hu,

Ming Yang

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(23), P. 8367 - 8367

Published: Nov. 30, 2022

Natural products have been an invaluable and useful source of anticancer agents over the years. Several compounds synthesized from natural by modifying their structures or using naturally occurring as building blocks in synthesis these for various purposes different fields, such biology, medicine, engineering. Multiple modern costly treatments applied to combat cancer limit its lethality, but results are not significantly refreshing. products, which a significant new therapeutic drugs, currently being investigated potential cytotoxic shown positive trend preclinical research prompted numerous innovative strategies order expedite clinical research. becoming increasingly important drug discovery due high molecular diversity novel biofunctionality. Furthermore, can provide superior efficacy safety unique properties. The objective current review is overview emergence treatment prevention cancer, chemosensitizers, immunotherapeutics, combinatorial therapies with other formulations mechanisms underlying

Language: Английский

Citations

251
The development and progress of nanomedicine for esophageal cancer diagnosis and treatment DOI
Xiaokun Li, Lingmin Chen,

Siyuan Luan

et al.

Seminars in Cancer Biology, Journal Year: 2022, Volume and Issue: 86, P. 873 - 885

Published: Jan. 21, 2022

Language: Английский

Citations

84
Emerging carbon-supported single-atom catalysts for biomedical applications DOI Creative Commons
Guangfu Liao, Li Zhang, Chunxue Li

et al.

Matter, Journal Year: 2022, Volume and Issue: 5(10), P. 3341 - 3374

Published: Oct. 1, 2022

Language: Английский

Citations

83
Application Prospects of Triphenylphosphine-Based Mitochondria-Targeted Cancer Therapy DOI Open Access

Xiaoxia Cheng,

Dong Feng,

Junyu Lv

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(3), P. 666 - 666

Published: Jan. 21, 2023

Cancer is one of the leading causes death and most important impediments to efforts increase life expectancy worldwide. Currently, chemotherapy main treatment for cancer, but it often accompanied by side effects that affect normal tissues organs. The search new alternatives has been a hot research topic in field antineoplastic medicine. Drugs targeting diseased or cells can significantly improve efficacy drugs. Therefore, organelle-targeted antitumor drugs are being explored, such as mitochondria-targeted Mitochondria central site cellular energy production plays an role cell survival death. Moreover, large number studies have shown close association between mitochondrial metabolism tumorigenesis progression, making mitochondria promising target cancer therapy. Combining agents with drug molecules effective way targeting. In addition, hyperpolarized tumor membranes membrane potentially allow selective accumulation This enhances direct killing while minimizing potential toxicity cells. this review, we discuss common pro-mitochondrial agents, advantages triphenylphosphine (TPP) mitochondrial-targeted therapy systematically summarize various TPP-based mitochondria-targeting anticancer

Language: Английский

Citations

47
Hyaluronic acid/dextran-based polymeric micelles co-delivering ursolic acid and doxorubicin to mitochondria for potentiating chemotherapy in MDR cancer DOI

Yufan Guo,

Xiuru Yang,

Yihong Zhang

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 332, P. 121897 - 121897

Published: Feb. 6, 2024

Language: Английский

Citations

16
Herbal Therapies for Cancer Treatment: A Review of Phytotherapeutic Efficacy DOI Creative Commons
Andrej Jenča, David K. Mills,

Hadis Ghasemi

et al.

Biologics, Journal Year: 2024, Volume and Issue: Volume 18, P. 229 - 255

Published: Sept. 1, 2024

Natural products have proven to be promising anti-cancer agents due their diverse chemical structures and bioactivity.This review examines central role in cancer treatment, focusing on mechanisms of action therapeutic benefits.Medicinal plants contain bioactive compounds, such as flavonoids, alkaloids, terpenoids polyphenols, which exhibit various anticancer properties.These compounds induce apoptosis, inhibit cell proliferation cycle progression, interfere with microtubule formation, act topoisomerase targets, angiogenesis, modulate key signaling pathways, improve the tumor microenvironment, reverse drug resistance activate immune cells.Herbal drugs offer advantages, particularly selective toxicity against cells, reducing adverse side effects associated conventional chemotherapy.Recent studies clinical trials highlight benefits herbal medicines alleviating effects, improving tolerance chemotherapy occurrence synergistic treatments.For example, medicine SH003 was found safe potentially effective treatment solid cancers, while Fucoidan showed anti-inflammatory properties that are beneficial for patients advanced cancer.The current research landscape is extensive.Numerous investigating efficacy, safety cancers lung, prostate, breast hepatocellular carcinoma.Promising developments include polypharmacological approach, combination therapies, immunomodulation improvement quality life.However, there still challenges development use natural drugs, need further into action, possible interactions optimal dosage.Standardizing extracts, bioavailability delivery, overcoming regulatory acceptance hurdles critical issues addressed.Nonetheless, warrant investigation development.Multidisciplinary collaboration essential advance therapy integrate these mainstream treatment.

Language: Английский

Citations

16
Porphyrin‐Based Covalent Organic Framework for Imaging‐Guided Cancer Combinatorial Immuno‐Sonodynamic Therapy DOI
Zhixiang Lu, Shuang Bai, Yonghe Jiang

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(45)

Published: Aug. 29, 2022

Abstract The rational design of tumor microenvironment (TME)‐activated nanomedicine is driving a new direction in immunology. Furthermore, the novel therapeutic mode ultrasound‐triggered sonodynamic therapy (SDT) has been proven to specifically activate immune response. Herein, well‐defined covalent organic framework (COF) with sonosensitive properties synthesized through experimental and theoretical verification, followed by efficient loading toll‐like receptor agonist (Poly(I:C)) situ growth paramagnetic transitional metallic oxide manganese bioxide (MnO 2 ). MnO ‐Poly(I:C)@COF shell can reverse reductive TME consuming glutathione (GSH) release Mn 2+ , simultaneously generating marked magnetic resonance imaging signals for real‐time guidance. Importantly, acts as an enzyme‐like nano‐catalyst promote TME‐overexpressed hydrogen peroxide (H O ) produce oxygen, facilitating SDT‐induced reactive oxygen species production, inducing immunogenic cell death, thereby boosting engine triggering abundant neoantigen exposure. With powerful assistance immunological agents Poly(I:C), triggered amplified refueling (stepping on accelerator) reduce immunosuppressive state. Overall, this study improves synthesis multifunctional COF expands its application. developed nano‐sonosensitizer system provides paradigm enhance SDT‐based high‐performance sonosensitizers, SDT‐mediated strong tumor‐suppressive efficiency activated effect represent promising combinatorial strategy cancer therapy.

Language: Английский

Citations

66
Tumor extracellular matrix modulating strategies for enhanced antitumor therapy of nanomedicines DOI
Meng Li, Yijing Zhang, Qin Zhang

et al.

Materials Today Bio, Journal Year: 2022, Volume and Issue: 16, P. 100364 - 100364

Published: July 15, 2022

Language: Английский

Citations

57
Transcytosis-enabled active extravasation of tumor nanomedicine DOI
Quan Zhou, Junjun Li, Jiajia Xiang

et al.

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 189, P. 114480 - 114480

Published: Aug. 8, 2022

Language: Английский

Citations

52