Trends in biotechnology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Protein-derived
biomaterials
are
currently
underrated
as
building
blocks
in
molecular
imprinting,
even
though
they
offer
several
benefits,
such
biocompatibility
and
safe
biodegradability.
Gelatin
is
a
biopolymer
that
can
be
easily
modified
with
pendant
double
bonds
for
polymerization,
making
it
suitable
tissue
engineering
biofabrication.
In
this
study,
we
used
gelatin
methacryloyl
(GelMA)
block
combined
imprinting
technology
to
create
an
original
class
of
bioinspired
nanotraps
specifically
capable
sequestering
the
proinflammatory
cytokine
interleukin-6
(IL-6).
The
stability
solution,
biocompatibility,
biodegradability
were
assessed.
selective
specific
IL-6,
showing
nanomolar
affinity
and,
when
tested
vitro
on
inflammation
cell
model,
sequestered
IL-6
dose-response
relationship.
Overall,
our
study
shows
protein
chemistry-driven
could
become
more
widely
devise
biocompatible
functional
nanomaterials.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Sept. 27, 2023
Abstract
Lymph
nodes
(LNs)
are
important
hubs
for
metastatic
cell
arrest
and
growth,
immune
modulation,
secondary
dissemination
to
distant
sites
through
a
series
of
mechanisms,
it
has
been
proved
that
lymph
node
metastasis
(LNM)
is
an
essential
prognostic
indicator
in
many
different
types
cancer.
Therefore,
oncologists
understand
the
mechanisms
tumor
cells
metastasize
LNs,
as
well
how
LNM
affects
prognosis
therapy
patients
with
cancer
order
provide
accurate
disease
assessment
effective
treatment
strategies.
In
recent
years,
updates
both
basic
clinical
studies
on
application
advanced
medical
technologies,
much
progress
made
understanding
strategies
diagnosis
LNM.
this
review,
current
knowledge
anatomical
physiological
characteristics
molecular
LNM,
described.
The
significance
summarized,
including
roles
playing
staging,
prediction,
selection
various
cancers.
And
novel
exploration
academic
disputes
recognition,
diagnosis,
therapeutic
interventions
LNs
also
discussed.
ACS Omega,
Journal Year:
2025,
Volume and Issue:
10(1), P. 1207 - 1225
Published: Jan. 3, 2025
Manufacturing
bioactive
materials
for
drug
delivery
involves
developing
that
interact
with
biological
tissues
to
release
drugs
in
a
controlled
and
targeted
manner.
The
goal
is
optimize
therapeutic
efficacy
reduce
side
effects
by
combining
knowledge
from
engineering,
biology,
pharmacology.
This
study
presents
detailed
bibliometric
analysis,
exploring
the
keywords
"manufacturing,"
"bioactive
materials,"
"drug
delivery"
identify
highlight
significant
advancements
field.
From
Web
of
Science,
36,504
articles
were
analyzed,
171
selected
deeper
identifying
key
journals,
countries,
institutions,
authors.
results
field's
interdisciplinary
nature,
grouped
into
four
main
themes,
including
regenerative
medicine,
scaffolds,
three-dimensional
(3D)
printing,
glass,
tissue
engineering.
Future
research
this
area
will
focus
on
more
effective
precise
systems
using
technologies
like
3D
printing
nanotechnology
enhance
customization
control
release,
aiming
efficient
therapies.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
22, P. 423 - 452
Published: Oct. 20, 2022
Osteoarthritis
(OA)
is
a
highly
prevalent
whole-joint
disease
that
causes
disability
and
pain
affects
patient's
quality
of
life.
However,
currently,
there
lack
effective
early
diagnosis
treatment.
Although
stem
cells
can
promote
cartilage
repair
treat
OA,
problems
such
as
immune
rejection
tumorigenicity
persist.
Extracellular
vesicles
(EVs)
transmit
genetic
information
from
donor
mediate
intercellular
communication,
which
considered
functional
paracrine
factor
cells.
Increasing
evidences
suggest
EVs
may
play
an
essential
complex
role
in
the
pathogenesis,
diagnosis,
treatment
OA.
Here,
we
introduced
OA
progression
by
influencing
inflammation,
metabolism,
aging.
Next,
discussed
blood,
synovial
fluid,
joint-related
for
diagnosis.
Moreover,
outlined
potential
modified
unmodified
their
combination
with
biomaterials
therapy.
Finally,
discuss
deficiencies
put
forward
prospects
challenges
related
to
application
field
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(16)
Published: March 2, 2024
Hybrid
nanomaterials
have
found
use
in
many
biomedical
applications.
This
article
provides
a
comprehensive
review
of
the
principles,
techniques,
and
recent
advancements
design
fabrication
hybrid
for
biomedicine.
We
begin
with
an
introduction
to
general
concept
material
hybridization,
followed
by
discussion
how
this
approach
leads
materials
additional
functionality
enhanced
performance.
then
highlight
forms
nanostructures,
nanocomposites,
metal-organic
frameworks,
biohybrids,
including
their
methods.
also
showcase
advance
engineering
context
nanomedicine,
regenerative
medicine,
diagnostics,
theranostics,
biomanufacturing.
Finally,
we
offer
perspectives
on
challenges
opportunities.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(16)
Published: March 2, 2024
Abstract
Hybrid
nanomaterials
have
found
use
in
many
biomedical
applications.
This
article
provides
a
comprehensive
review
of
the
principles,
techniques,
and
recent
advancements
design
fabrication
hybrid
for
biomedicine.
We
begin
with
an
introduction
to
general
concept
material
hybridization,
followed
by
discussion
how
this
approach
leads
materials
additional
functionality
enhanced
performance.
then
highlight
forms
nanostructures,
nanocomposites,
metal–organic
frameworks,
biohybrids,
including
their
methods.
also
showcase
advance
engineering
context
nanomedicine,
regenerative
medicine,
diagnostics,
theranostics,
biomanufacturing.
Finally,
we
offer
perspectives
on
challenges
opportunities.
